Results 31 to 40 of about 6,185 (114)
Unraveling Endocannabinoid Signaling Pathways in Cisplatin‐Induced Ototoxicity
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.We performed a comprehensive molecular profiling of the endocannabinoid (eCB) system (ECS) in an auditory Hair cell (HC)‐like cell line (1). Afterwards, we developed suitable in vitro and in vivo models of cisplatin‐induced ototoxicity where we identified distinct components of the ECS (CB2R, DAGLβ and ABHD6) as molecular targets of the drug (2 ...
Sakthimala Palaniappan +12 more
wiley +1 more source
Novel Technologies for Exploring the Skin–Brain Axis
Advanced Sensor Research, Volume 5, Issue 2, February 2026.The skin–brain axis mediates bidirectional communication between cutaneous physiology and the nervous system, influencing sensation, inflammation, and disease. This review surveys emerging microsensor, nanosensor, and bioelectronic technologies integrated with advanced skin and neural models, highlighting multimodal, real‐time strategies to decode ...
Dahiana Mojena Medina, Francesca Santoro
wiley +1 more source
Physiological Reports, Volume 14, Issue 4, February 2026.Abstract Palmitoylethanolamide (PEA) is an endogenous lipid mediator with immunomodulatory actions, yet its effects in skeletal muscle remain poorly defined. We examined whether PEA influences myogenesis and profiled the acute transcriptomic response of differentiated C2C12 myotubes to 10 μM PEA. PEA decreased myotube number (90.3 ± 10.6 vs. 112.6 ± 10.
Paige L. Cole +4 more
wiley +1 more source
Aging Cell, Volume 25, Issue 1, January 2026.Interrogation of the cellular and transcriptional profile of IMAT in individuals with KOA reveals a pro‐inflammatory phenotype. ABSTRACT Individuals with knee osteoarthritis (KOA) have skeletal muscle changes around the knee joint including reduced quadricep muscle mass and increased intermuscular adipose tissue (IMAT).
Line O. Elingaard‐Larsen +10 more
wiley +1 more source
The fat‐heart entanglement and the role of ‘osteopontin mechanics’ in cardiometabolic senescence
European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.Abstract Background Residual cardiovascular (CV) risk persists despite therapeutic advances. Obesity is heterogeneous, and visceral adipose tissue (VAT) dysfunction (‘adiposopathy’) complicates risk stratification. Osteopontin (OPN) is a pleiotropic mediator implicated in VAT inflammation, senescence‐associated pathways, atherosclerosis and myocardial ...
Cristina Michelauz +3 more
wiley +1 more source
Aging modifies the enzymatic activities involved in 2‐arachidonoylglycerol metabolism
BioFactors, 2012 AbstractOne of the principal monoacylglycerol (MAG) species in animal tissues is 2‐arachidonoylglycerol (2‐AG), and the diacylglycerol lipase (DAGL) pathway is the most important 2‐AG biosynthetic pathway proposed to date. Lysophosphatidate phosphatase (LPAase) activity is part of another 2‐AG‐forming pathway in which monoacylglycerol lipase (MAGL) is ...
Pascual, Ana Clara +3 more
openaire +3 more sources
Andrologia, Volume 2026, Issue 1, 2026.Introduction Cannabis is the most widely used drug in Morocco, particularly among young individuals, with potential repercussions on their reproductive health. Through its interaction with the endocannabinoid system, cannabis may interfere with spermatogenesis and hormonal regulation.
Adil Kbirou +6 more
wiley +1 more source
Anandamide amidohydrolase reacting with 2‐arachidonoylglycerol, another cannabinoid receptor ligand
FEBS Letters, 1998 Two endogenous ligands for cannabinoid receptors, anandamide (arachidonylethanolamide) and 2‐arachidonoylglycerol, lose their biological activities by enzymatic hydrolysis. A cDNA for a rat liver enzyme hydrolyzing anandamide as well as oleamide was overexpressed in COS‐7 cells.
Goparaju, Sravan Kumar +3 more
openaire +2 more sources
Autism Research, Volume 18, Issue 12, Page 2368-2381, December 2025.ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication deficits, repetitive behaviors, and sensory abnormalities. Sodium valproate (VPA) exposure during embryonic development is a well‐established preclinical model for ASD, leading to increased oxidative stress in the developing brain, including ...
Karla C. M. Costa +13 more
wiley +1 more source
MedComm, Volume 6, Issue 12, December 2025.Alcohol‐related (ALD) and metabolic dysfunction‐associated (MASLD) steatotic liver disease, while initiated by distinct etiologies (ethanol vs. metabolic stress), converge on shared core pathogenic pathways that drive progression. These include dysregulated lipid metabolism, programmed cell death, cellular senescence, gut dysbiosis, and immune ...
Yupin Tan +3 more
wiley +1 more source