Results 41 to 50 of about 5,480 (215)

Skin Penetration and Stability Enhancement of Celastrus paniculatus Seed Oil by 2-Hydroxypropyl-β-Cyclodextrin Inclusion Complex for Cosmeceutical Applications

Scientia Pharmaceutica, 2018
This study aimed to encapsulate Celastrus paniculatus seed oil (CPSO) in 2-hydroxypropyl-β-cyclodextrin (HPβCD) cavities and investigate their biological activity, physicochemical stability, and skin penetration by vertical Franz diffusion ...
Warintorn Ruksiriwanich, Jakkapan Sirithunyalug, Chiranan Khantham, Krot Leksomboon, Pensak Jantrawut   +4 more
doaj   +1 more source

Inhalable Protein Powder Prepared by Spray-Freeze-Drying Using Hydroxypropyl-β-Cyclodextrin as Excipient

Pharmaceutics, 2021
The prospect of inhaled biologics has garnered particular interest given the benefits of the pulmonary route of administration. Pertinent considerations in producing inhalable dry powders containing biological medicines relate to aerosol performance and ...
Jason C. K. Lo, Harry W. Pan, Jenny K. W. Lam   +2 more
doaj   +1 more source

Tissue compatibility of SN-38-loaded anticancer nanofiber matrices [PDF]

, 2018
Delivery of chemotherapy in the surgical bed has shown preclinical activity to control cancer progression upon subtotal resection of pediatric solid tumors, but whether this new treatment is safe for tumor-adjacent healthy tissues remains unknown.
Botteri, Gaia, Cano Casas, Francesc, Castillo Ecija, Helena, Garcia Alvarez, Laura, Manzanares Quintela, Alejandro, Montero Carcaboso, Ángel, Monterrubio, Carles, Mora Graupera, Jaume, Pascual Pasto, Guillem, Restrepo-Perdomo, Camilo A., Ruiz, Bonaventrua, Sosnik, alejandro, Suñol Capella, Mariona, Tornero García, José Antonio, Vazquez Carrera, Manuel   +14 more
core   +2 more sources

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Formulation and characterization of biocompatible and stable I.V. itraconazole nanosuspensions stabilized by a new stabilizer polyethylene glycol-poly(β-Benzyl-L-aspartate) (PEG-PBLA) [PDF]

, 2017
Amphiphilic block copolymers, PEG-PBLA with different molecular weights, were synthesized and used as new stabilizers for Itraconazole nannosuspensions (ITZ-PBLA-Nanos).
Cao, Y, Chen, D, Han, J, Li, M, Li, X, Pu, X, Wang, H, Wei, Z, Yin, L, Zong, L   +9 more
core   +2 more sources

Synergistic Dual Slip‐Link Toughening of a Water‐Rich Double Network Hydrogel Combining Slide‐Ring and Highly Entangled Networks

Advanced Science, EarlyView.
Two distinct slip‐link mechanisms – the slide‐ring pulley effect and highly entangled chains – are combined in a water‐rich double network hydrogel, achieving synergistic toughening, near‐complete reversibility, and exceptional friction tear resistance at >$>$91 wt.% water.
Subhankar Mandal, Saleh Assadi, Aseem Milind Visal, Ignacio Lorente Montero, Franck J. Vernerey, Carson J. Bruns   +5 more
wiley   +1 more source

Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress

Redox Biology, 2019
Familial early-onset forms of Alzheimer's disease (AD) are linked to overproduction of amyloid beta (Aβ) peptides, while decreased clearance of Aβ is the driving force leading to its toxic accumulation in late-onset (sporadic) AD. Oxidative modifications
Cristina de Dios, Isabel Bartolessis, Vicente Roca-Agujetas, Elisabet Barbero-Camps, Montserrat Mari, Albert Morales, Anna Colell   +6 more
doaj   +1 more source

Phenotype assessment for neurodegenerative murine models with ataxia and application to Niemann–Pick disease, type C1

Biology Open, 2022
Identifying meaningful predictors of therapeutic efficacy from preclinical studies is challenging. However, clinical manifestations occurring in both patients and mammalian models offer significant translational value.
Julia Yerger, Antony C. Cougnoux, Craig B. Abbott, Rachel Luke, Tannia S. Clark, Niamh X. Cawley, Forbes D. Porter, Cristin D. Davidson   +7 more
doaj   +1 more source

Membrane fluidity changes in goat sperm induced by cholesterol depletion using beta-cyclodextrin [PDF]

, 2007
Cholesterol efflux from membranes promotes acrosome reaction in goat spermatozoa. In 1 h of incubation of sperm in the presence of beta-cyclodextrin (βCD), all the interchangeable cholesterol is desorbed from sperm membranes, although acrosome reaction ...
Companyó, Mònica, Iborra, Antoni, Martínez, Paz, Morros, Antoni, Villaverde, Joaquim   +4 more
core   +1 more source

Molecular Mobility of N‐Acetylgalactosamine‐Modified Cyclodextrins on a Polyrotaxane for Highly Efficient Liver Targeting of Antibody Chimeras and Genome‐Editing Ribonucleoproteins

Advanced Science, EarlyView.
Monovalent N‐acetylgalactosamine (GalNAc)‐modified polyrotaxane enables efficient liver targeting by utilizing ligand mobility. The sliding and rotating cyclic components i.e., cyclodextrin in the polyrotaxane dynamically cluster GalNAc moieties, thereby mimicking trivalent interactions with asialoglycoprotein receptors.
Toru Taharabaru, Keiichi Motoyama, Yuting Wen, Zhongxing Zhang, Xuehao Tian, Jun Li, Taishi Higashi   +6 more
wiley   +1 more source