Characterization of hydroxypropyl-beta-cyclodextrins used in the treatment of Niemann-Pick Disease type C1. [PDF]
PLoS ONE, 2017 2-Hydroxypropyl-beta-cyclodextrin (HPβCD) has gained recent attention as a potential therapeutic intervention in the treatment of the rare autosomal-recessive, neurodegenerative lysosomal storage disorder Niemann-Pick Disease Type C1 (NPC1).
Alfred L Yergey +5 more
doaj +1 more source
The formation of host–guest complexes between surfactants and cyclodextrins [PDF]
, 2014 Cyclodextrins are able to act as host molecules in supramolecular chemistry with applications ranging from pharmaceutics to detergency. Among guest molecules surfactants play an important role with both fundamental and practical applications.
Söderman, Olle, Valente, Artur J. M.
core +1 more source
Dissolution/permeation of albendazole in the presence of cyclodextrin and bile salts:a mechanistic in vitro study into factors governing oral bioavailability [PDF]
, 2022 We aimed to understand the impact of the interplay between bile salts and cyclodextrins on the dissolution-permeation of poorly soluble drug compounds with a moderate-strong binding constant to cyclodextrin.
Bauer-Brandl, Annette +3 more
core +1 more source
Nanomicellar Lenalidomide-Fenretinide Combination Suppresses Tumor Growth in an MYCN Amplified Neuroblastoma Tumor [PDF]
, 2020 Purpose: In a previous study, we demonstrated that the combination of fenretinide with lenalidomide, administered by a novel nanomicellar formulation (FLM), provided a strong antitumor effect in a neuroblastoma TrkB-expressing tumor.
Brodeur G. M. +7 more
core +1 more source
Effects of Hydroxypropyl-Beta-Cyclodextrin on Cultured Brain Endothelial Cells
Molecules, 2022 The application of 2-hydroxypropyl-beta-cyclodextrin (HPBCD) in the treatment of the rare cholesterol and lipid storage disorder Niemann–Pick disease type C opened new perspectives in the development of an efficient therapy.
Szilvia Veszelka +9 more
doaj +1 more source
Atorvastatin Provides a New Lipidome Improving Early Regeneration After Partial Hepatectomy in Osteopontin Deficient Mice [PDF]
, 2018 Osteopontin (OPN), a multifunctional cytokine that controls liver glycerolipid metabolism, is involved in activation and proliferation of several liver cell types during regeneration, a condition of high metabolic demands.
Aspichueta Celaá, Patricia +10 more
core +4 more sources
Neurobiology of Disease, 2021 Niemann-Pick type C disease is a rare and fatal lysosomal storage disorder presenting severe neurovisceral symptoms. Disease-causing mutations in genes encoding either NPC1 or NPC2 protein provoke accumulation of cholesterol and other lipids in specific ...
Amélie Barthelemy +9 more
doaj +1 more source
Release of Moxifloxacin from Contact Lenses Using an In Vitro Eye Model: Impact of Artificial Tear Fluid Composition and Mechanical Rubbing [PDF]
, 2016 Phan, C.-M., Bajgrowicz-Cieslak, M., Subbaraman, L. N., & Jones, L. (2016). Release of Moxifloxacin from Contact Lenses Using an In Vitro Eye Model: Impact of Artificial Tear Fluid Composition and Mechanical Rubbing.
Chau-Minh Phan +4 more
core +2 more sources
Heritage ScienceThe fragility and weakness of historical, archaeological, and heritage leather artifacts in museums, and libraries due to unsuitable environmental conditions are significant challenges.
Gomaa Abdel-Maksoud +3 more
doaj +1 more source
Advanced Science, EarlyView.Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu +14 more
wiley +1 more source