Results 11 to 20 of about 5,480 (215)
Bile acid and sterol solubilization in 2-hydroxypropyl-beta-cyclodextrin.
Journal of Lipid Research, 1992 The use of 2-hydroxypropyl-beta-cyclodextrin has made it possible to prepare stable aqueous solutions of cholesterol, 26-hydroxycholesterol, 7 alpha-hydroxycholesterol, and monohydroxy bile acids such as lithocholic and 3 beta-hydroxy-5-cholenoic acids ...
J De Caprio, J Yun, NB Javitt
doaj +3 more sources
Use of 2-Hydroxypropyl-Beta-Cyclodextrin for Niemann-Pick Type C Disease [PDF]
, 2017 Niemann-Pick disease type C (NPD-C) is a rare neurodegenerative disorder characterized by a lysosomal storage disorder. Treatment has been supportive and symptomatic.
Company-Albir, María José +3 more
core +3 more sources
Intrathecal 2-hydroxypropyl-beta-cyclodextrin in a single patient with Niemann-Pick C1. [PDF]
Mol Genet Metab, 2015 Niemann-Pick C, type 1 (NPC1) is a progressive autosomal recessive neurologic disease caused by defective intracellular cholesterol and lipid trafficking. There are currently no United States Food and Drug Administration approved treatments for NPC1.
Maarup TJ +7 more
europepmc +4 more sources
Hearing Loss and Otopathology Following Systemic and Intracerebroventricular Delivery of 2-Hydroxypropyl-Beta-Cyclodextrin. [PDF]
J Assoc Res Otolaryngol, 2015 Cyclodextrins are simple yet powerful molecules widely used in medicinal formulations and industry for their ability to stabilize and solubilize guest compounds. However, recent evidence shows that 2-hydroxypropyl-β-cyclodextrin (HPβCD) causes severe hearing loss in mice, selectively killing outer hair cells (OHC) within 1 week of subcutaneous drug ...
Cronin S +4 more
europepmc +4 more sources
Enhancement of zona binding using 2-hydroxypropyl- beta-cyclodextrin [PDF]
Human Reproduction, 2000 Since membrane cholesterol depletion is known to play an important role in sperm capacitation, we have investigated the effect of 2-hydroxypropyl-beta-cyclodextrin, a cyclic oligosaccharide that mediates cholesterol efflux, on sperm functions. Sperm treatment with cyclodextrin did not affect the motility patterns but induced an increase in sperm ...
J, Parinaud +4 more
openaire +2 more sources
Pharmaceutics, 2020 Cyclodextrin polymers have high applicability in pharmaceutical formulations due to better biocompatibility, solubility enhancement, loading capacity and controlled drug release than their parent, cyclodextrins.
Giovanna Rassu +7 more
doaj +1 more source
Fostering collaborative research for rare genetic disease: The example of Niemann-Pick type C disease [PDF]
, 2016 Rare disease represents one of the most significant issues facing the medical community and health care providers worldwide, yet the majority of these disorders never emerge from their obscurity, drawing little attention from the medical community or the
Austin, Christopher P +8 more
core +3 more sources
A hopeful therapy for Niemann-Pick C diseases [PDF]
, 2017 Not abstract ...
Erickson, Robert P. +1 more
core +1 more source
Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model [PDF]
, 2017 Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental ...
Aikawa +45 more
core +2 more sources
Chemical and Pharmaceutical Bulletin, 1990 Possible utility of hydroxyalkylated beta-cyclodextrin (beta-CyD) derivatives as parenteral drug carriers was investigated, using nimodipine, a dihydropyridine derivative with calcium antagonistic action, as a model drug. The aqueous solubility of nimodipine increased linearly with increase in the concentration of hydroxyalkylated beta-CyDs, showing an
YOSHIDA, Atsuya +5 more
openaire +3 more sources