Results 21 to 30 of about 5,480 (215)

Synthesis of 27-hydroxycholesterol in rat liver mitochondria: HPLC assay and marked activation by exogenous cholesterol.

Journal of Lipid Research, 1993
Sterol 27-hydroxylase, the mitochondrial enzyme that catalyzes the first step in oxidation of the sterol side chain in hepatic bile acid synthesis, also catalyzes the synthesis of 27-hydroxycholesterol from cholesterol.
B Petrack, B J Latario
doaj   +1 more source

Precision medicine in cats:novel niemann-pick type C1 diagnosed by whole-genome sequencing [PDF]

, 2017
State-of-the-art health care includes genome sequencing of the patient to identify genetic variants that contribute to either the cause of their malady or variants that can be targeted to improve treatment.
1, 1 B. Gandolfi, 1 C. R. Reinero, 1 D. P. O'Brien, 1 J. L. Spooner, 2 L. A. Lyons, Adam R. Boyko, and 99 Lives Consortium: Danielle Aberdein, Christopher B. Kaelin, Christopher R. Helps, D. A. Mauler, Dorian J. Garrick, Elizabeth A. Wilcox, Emilie Leclerc, Gregory S. Barsh, Hannes Lohi, Holly C. Beale, Jeffrey A. Brockman, John S. Munday, Jonathan E. Fogle, Joshua A. Stern, Julia H. Wildschutte, Karen A. Terio, Maria Kaukonen, Maria Longeri, Marjo K. Hytönen, Marta G. Castelhano, Max F. Rothschild, Michael J. Montague, N. Matthew Ellinwood, Niels C. Pedersen, Patricia P. Chan, Paulo C. Alves, Richard Malik, Rory J. Todhunter, Tosso Leeb, Wesley C. Warren, William F. Swanson, William J. Murphy, Yu Ueda   +39 more
core   +1 more source

Use of cyclodextrins for manipulating cellular cholesterol content

Journal of Lipid Research, 1997
Previous studies from this laboratory have demonstrated that exposure of tissue culture cells to cyclodextrins results in rapid cholesterol depletion.
A E Christian, M P Haynes, M C Phillips, G H Rothblat   +3 more
doaj   +1 more source

Exploring the interactions of irbesartan and irbesartan–2-hydroxypropyl-β-cyclodextrin complex with model membranes [PDF]

, 2017
The interactions of irbesartan (IRB) and irbesartan–2-hydroxypropyl-β-cyclodextrin (HP-β-CD) complex with Dipalmitoyl Phosphatidylcholine (DPPC) bilayers have been explored utilizing an array of biophysical techniques ranging from Differential Scanning ...
Amenitsch, H, Becker-Baldus, J, Chatziathanasiadou, MV, Christodoulou, E, Glaubitz, C, Iatrou, H, Kellici, TF, Krajnc, A, Kriechbaum, M, Liossi, Α, Mali, G, Mania, M, Mavromoustakos, T, Megariotis, G, Ntountaniotis, D, Pitsikalis, M, Rappolt, M, Theodorou, DN, Tzakos, AG, Valsami, G   +19 more
core   +1 more source

Formulation of itraconazole nanococrystals and evaluation of their bioavailability in dogs [PDF]

, 2014
The aim of the study is to increase the bioavailability of itraconazole (ITRA) using nanosized cocrystals prepared via wet milling of ITRA in combination with dicarboxylic acids.
Adriaensens, Peter, Carleer, Robert, De Beer, Thomas, De Smet, Lieselotte, Remon, Jean Paul, Saerens, Lien, Van Bocxlaer, Jan, Vervaet, Chris   +7 more
core   +1 more source

A Zinc Oxide Interconnected Hydroxypropyl-Beta-Cyclodextrin/rGO Nanocomposite as an Electrocatalyst for Melatonin Detection: An Ultra-Sensitive Electrochemical Sensor [PDF]

Sensors
Kuo-Yuan Hwa, Aravindan Santhan
exaly   +2 more sources

EO9 (Apaziquone): from the clinic to the laboratory and back again [PDF]

, 2013
EO9 (Apaziquone) is a bioreductive drug that has a chequered history. It underwent clinical trial but failed to show activity in phase II clinical trials when administered i.v.
Aamdal, Adams, Bailey, Bailey, Basu, Bibby, Bibby, Burd, Butler, Cadenas, Ceelen, Choudry, Collard, Connors, Cowan, Cummings, Denny, Dirix, Ernster, Fitzsimmons, Gofrit, Hall, Hargreaves, Hay, Hay, Hay, Hendricksen, Hendricksen, Hendriks, Jain, Loadman, Lu, Maliepaard, Masters, Masters, McKeown, McLeod, Milbank, Minchinton, Oostveen, Pavlidis, Phillips, Phillips, Phillips, Phillips, Phillips, Phillips, Pizao, Plumb, Plumb, Plumb, Puri, Rademakers, Robertson, Robertson, Roed, Schellens, Segura-Aguilar, Siegel, Siegel, Smitskamp-Wilms, Stratford, Sylvester, Tercel, van der Heijden, van der Schoot, van der Schoot, van der Schoot, Vaupel, Vaupel, Walton, Walton, Workman, Workman, Workman, Zappa   +75 more
core   +1 more source

OCULAR BIOAVAILABILITY OF ENROFLOXACIN-CYCLODEXTRIN COMPLEXES FROM CERTAIN OPHTHALMIC PREPARATIONS IN RABBITS EYES

Zagazig Journal of Pharmaceutical Sciences, 2006
The effect of inclusion complexes of enrofloxacin (Enr) with cyclodextrins (CyDs): hydroxypropyl beta-cyclodextrin (HP-β -CYD) and beta-cyclodextrin (β -CyD) was studied. These complexes were prepared in a molar ratio (1:2).
Hamdy Abd El-Aleem , Esmail Ramadan , Osama Soliman , Samy Kheira , Marwa El-Dahhan   +4 more
doaj   +1 more source

Linear cyclodextrin polymer prodrugs as novel yherapeutics for Niemann-Pick type C1 disorder [PDF]

, 2018
Niemann-Pick Type C1 disorder (NPC) is a rare lysosomal storage disease characterized by the accumulation of cholesterol in lysosomes. NPC has no FDA approved treatments yet, however 2-hydroxypropyl-β-cyclodextrin (HPβCD) has shown efficacy for treating ...
Aditya Kulkarni, Alberto Macone, Atul Dolas, Jessica Dragotto, Maria Teresa Fiorenza, Paola Caporali, Ramesh Jayaraman, Sandeep Goyal, Soniya Johny   +8 more
core   +1 more source

Development of an In Vitro Ocular Platform to Test Contact Lenses [PDF]

, 2016
The definitive version of Development of an in Vitro Ocular Platform to Test Contact Lenses was published by Emerald www.emeraldinsight.com in Journal of Visualized Experiments, (110) (2016) https://doi.org/10.3791/53907Currently, in vitro evaluations of
Gao, Huayi, Jones, Lyndon W., Phan, Chau-Minh, Rossy, Jordan, Subbaraman, Lakshman N., Walther, Hendrik   +5 more
core   +1 more source