2-Hydroxypropyl-beta-cyclodextrin Treatment Does Not Induce Atherosclerotic Lesion Regression in Western-Type Diet-Fed Apolipoprotein E Knockout Mice [PDF]
Biomolecules, 2022 2-Hydroxypropyl-beta-cyclodextrin (2HPβCD) is able to bind and solubilize unesterified cholesterol and may therefore be able to reverse the deposition of cholesterol in macrophages within the aortic vessel wall, a hallmark of atherosclerotic ...
Olga S.C. Snip +4 more
doaj +5 more sources
Direct administration of 2-Hydroxypropyl-Beta-Cyclodextrin into guinea pig cochleae: Effects on physiological and histological measurements. [PDF]
PLoS ONE, 2017 2-Hydroxypropyl-Beta-Cyclodextrin (HPβCD) can be used to treat Niemann-Pick type C disease, Alzheimer's disease, and atherosclerosis. But, a consequence is that HPβCD can cause hearing loss. HPβCD was recently found to be toxic to outer hair cells (OHCs)
J T Lichtenhan +4 more
doaj +6 more sources
2-Hydroxypropyl-beta-cyclodextrin (HPβCD) reduces age-related lipofuscin accumulation through a cholesterol-associated pathway [PDF]
Scientific Reports, 2017 Oxidative stress causes significant increases in both cholesterol uptake and intracellular accumulation of the aging biomarker lipofuscin. Here we show that HPβCD addition mitigates these adverse effects in human fibroblasts by significantly reducing ...
Jason Gaspar +2 more
doaj +5 more sources
Pharmacokinetic Properties of Fluorescently Labelled Hydroxypropyl-Beta-Cyclodextrin [PDF]
Biomolecules, 2019 2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is utilized in the formulation of pharmaceutical products and recently orphan designation was granted for the treatment of Niemann−Pick disease, type C.
Judit Váradi +2 more
exaly +6 more sources
Measurements From Ears With Endolymphatic Hydrops and 2-Hydroxypropyl-Beta-Cyclodextrin Provide Evidence That Loudness Recruitment Can Have a Cochlear Origin [PDF]
Frontiers in Surgery, 2021 Background: Loudness recruitment is commonly experienced by patients with putative endolymphatic hydrops. Loudness recruitment is abnormal loudness growth with high-level sounds being perceived as having normal loudness even though hearing thresholds are
Shannon M. Lefler +5 more
doaj +2 more sources
Doxorubicin·Hydrochloride/Cisplatin-Loaded Hydrogel/Nanosized (2-Hydroxypropyl)-Beta-Cyclodextrin Local Drug-Delivery System for Osteosarcoma Treatment In Vivo [PDF]
Nanomaterials, 2019 Osteosarcoma (OSA) is a difficult cancer to treat due to its tendency for relapse and metastasis; advanced methods are therefore required for OSA treatment.
Sun Jung Yoon +3 more
doaj +2 more sources
Compatibility Studies of Sildenafil-HPBCD Inclusion Complex with Pharmaceutical Excipients [PDF]
PharmaceuticsBackground/Objectives: In the past two decades, the primary therapeutic use of sildenafil has shifted significantly, from the treatment of angina to managing erectile dysfunction, and since the early 2000s it has been used in the treatment of pulmonary ...
Răzvan Adrian Bertici +11 more
doaj +2 more sources
Radiolabelled Cyclodextrins for the Positron Emission Tomography Imaging of Breast Cancer: Preclinical Perspectives [PDF]
Clinical and Translational ScienceGiven the increasing incidence and mortality of breast cancer, the development of target‐specific imaging probes for early disease detection seems straightforward.
Tamás Sass +10 more
doaj +2 more sources
Pharmaceutics, 2023 Antihistamines such as levocetirizine dihydrochloride (LC) are commercially used in oral tablets and oral drops to reduce allergic symptoms. In this study, LC was nano-spray-dried using three mucoadhesive polymers and four cyclodextrin species to form ...
Mirella Mirankó +4 more
doaj +1 more source
Molecules, 2023 Rutin is a natural flavonoid that carries out a variety of biological activities, but its application in medicine and food is limited by its water solubility.
Chaokang Chang +5 more
doaj +1 more source