Results 11 to 20 of about 12,744 (156)
The Oxysterol 25-Hydroxycholesterol Inhibits Replication of Murine Norovirus [PDF]
Viruses, 2019 Cholesterol, an essential component of mammalian cells, is also an important factor in the replicative-cycles of several human and animal viruses.
Ghada T. Shawli +3 more
doaj +5 more sources
Inhibition of cellular cholesterol efflux by 25-hydroxycholesterol.
Journal of Lipid Research, 1995 The effect of oxysterols on efflux of cholesterol from mouse L-cell fibroblasts, rat Fu5AH hepatoma cells, J774 macrophages, and human EA.hy 926 endothelial cells was studied.
E P Kilsdonk +3 more
doaj +3 more sources
25-Hydroxycholesterol Effect on Membrane Structure and Mechanical Properties. [PDF]
Int J Mol Sci, 2021 Cholesterol is responsible for the plasticity of plasma membranes and is involved in physiological and pathophysiological responses. Cholesterol homeostasis is regulated by oxysterols, such as 25-hydroxycholesterol. The presence of 25-hydroxycholesterol at the membrane level has been shown to interfere with several viruses’ entry into their target ...
Domingues MM +3 more
europepmc +6 more sources
SGLT2 Inhibitors May Restore Endothelial Barrier Interrupted by 25-Hydroxycholesterol. [PDF]
Molecules, 2023 SGLT2 (Sodium-glucose Cotransporter-2) inhibitors are newer glucose-lowering drugs with many cardiovascular benefits that are not fully understood yet. Endothelial integrity plays a key role in cardiovascular homeostasis. 25-hydroxycholesterol (25-OHC), which is a proatherogenic stimuli that impairs endothelial barrier functions.
Pawlos A +5 more
europepmc +4 more sources
25-Hydroxycholesterol as a Signaling Molecule of the Nervous System. [PDF]
Biochemistry (Mosc), 2022 Cholesterol is an essential component of plasma membrane and precursor of biological active compounds, including hydroxycholesterols (HCs). HCs regulate cellular homeostasis of cholesterol; they can pass across the membrane and vascular barriers and act distantly as para- and endocrine agents. A small amount of 25-hydroxycholesterol (25-HC) is produced
Odnoshivkina UG +2 more
europepmc +3 more sources
25-Hydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell Line. [PDF]
Molecules, 2021 25-hydroxycholesterol (25-HC) is an oxysterol synthesized from cholesterol by cholesterol-25-hydroxylase during cholesterol metabolism. The aim of this study was to verify whether 25-HC induces oxiapoptophagy in fibroblasts. 25-HC not only decreased the survival of L929 cells, but also increased the number of cells with condensed chromatin and altered ...
You JS +11 more
europepmc +5 more sources
Transformation of 25-Hydroxycholesterol by Rhizoctonia muneratii [PDF]
Applied and Environmental Microbiology, 1982 Rhizoctonia muneratii ATCC 13247 was capable of catalyzing the conversion of 25-hydroxycholesterol to the 3-oxo-4-ene. Hydroxylation at the 6α and 6β positions with the concomitant 3-oxo-4-ene transformation was also observed.
M E, Wozny +3 more
openaire +2 more sources
Antioxidants, 2021 The aim of the present paper is to assess the relationship between oxysterol levels and retinal microvascular function in individuals of various age groups, free of clinically evident diseases.
Hala Shokr +2 more
doaj +1 more source
Journal of Lipid Research, 1999 25-Hydroxycholesterol negatively regulates cholesterol synthesis and activates cholesterol esterification in a variety of cultured cells. Concurrent with these effects, 25-hydroxycholesterol also stimulates the synthesis of sphingomyelin in Chinese ...
Thomas A. Lagace +3 more
doaj +1 more source
Cholesterol 25-hydroxylation activity of CYP3A
Journal of Lipid Research, 2011 To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda +8 more
doaj +1 more source