The 5′ and 3′ Untranslated Regions of the Japanese Encephalitis Virus (JEV): Molecular Genetics and Higher Order Structures [PDF]
Frontiers in Microbiology, 2021 The untranslated region (UTRs) of viral genome are important for viral replication and immune modulation. Japanese encephalitis virus (JEV) is the most significant cause of epidemic encephalitis worldwide.
Hong Liu +4 more
doaj +2 more sources
Alternative polyadenylation produces multiple 3’ untranslated regions of odorant receptor mRNAs in mouse olfactory sensory neurons [PDF]
BMC Genomics, 2019 Background Odorant receptor genes constitute the largest gene family in mammalian genomes and this family has been extensively studied in several species, but to date far less attention has been paid to the characterization of their mRNA 3′ untranslated ...
Mohamed Doulazmi +4 more
doaj +2 more sources
Toward a systematic understanding of mRNA 3' untranslated regions. [PDF]
Proc Am Thorac Soc, 2011 Messenger RNAs (mRNAs) contain prominent untranslated regions (UTRs) that are increasingly recognized to play roles in mRNA processing, transport, stability, and translation. 3' UTRs are believed to harbor recognition sites for a diverse set of RNA-binding proteins that regulate gene expression as well as most active microRNA target sites. Although the
Zhao W, Blagev D, Pollack JL, Erle DJ.
europepmc +4 more sources
3′untranslated regions: regulation at the end of the road
Current Genetics, 2018 Post-transcriptional gene regulation in bacteria plays a major role in the adaptation of bacterial cells to the changing conditions encountered in the environment. In bacteria, most of the regulation at the level of mRNA seems to be targeting the 5'untranslated regions where accessibility to the ribosome-binding site can be modulated to alter gene ...
Youssef El Mouali, Carlos Balsalobre
openaire +4 more sources
Detection of Differentially Expressed Cleavage Site Intervals Within 3′ Untranslated Regions Using CSI-UTR Reveals Regulated Interaction Motifs [PDF]
Frontiers in Genetics, 2019 The length of untranslated regions at the 3′ end of transcripts (3′UTRs) is regulated by alternate polyadenylation (APA). 3′UTRs contain regions that harbor binding motifs for regulatory molecules. However, the mechanisms that coordinate the 3′UTR length
Benjamin J. Harrison +14 more
doaj +2 more sources
A Luciferase-Based Approach for Functional Screening of 5′ and 3′ Untranslated Regions of the mRNA Component for mRNA Vaccines [PDF]
VaccinesBackground/Objectives: The recent COVID-19 pandemic caused by SARS-CoV-2 infection has highlighted the need for protocols for rapid development of efficient screening methods to search for the optimal mRNA vaccine structures against mutable viral agents.
Maria Rubtsova +15 more
doaj +2 more sources
Genome-wide analysis of 3′-untranslated regions supports the existence of post-transcriptional regulons controlling gene expression in trypanosomes [PDF]
PeerJ, 2013 In eukaryotic cells, a group of messenger ribonucleic acids (mRNAs) encoding functionally interrelated proteins together with the trans-acting factors that coordinately modulate their expression is termed a post-transcriptional regulon, due to their ...
Javier G. De Gaudenzi +3 more
doaj +6 more sources
Discovering non-coding RNA elements in Drosophila 3' untranslated regions. [PDF]
Int J Bioinform Res Appl, 2014 The Non-Coding RNA (ncRNA) elements in the 3' Untranslated Regions (3'-UTRs) are known to participate in the genes' post-transcriptional regulations. Inferring co-expression patterns of the genes through clustering these 3'-UTR ncRNA elements will provide invaluable insights for studying their biological functions. In this paper, we propose an improved
Zhong C, Andrews J, Zhang S.
europepmc +6 more sources
MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers. [PDF]
PLoS ONE, 2012 MicroRNAs are key regulators of gene expression and have been shown to have altered expression in a variety of cancer types, including epithelial ovarian cancer.
Georgina L Ryland +9 more
doaj +2 more sources
Alternative 3'-untranslated regions regulate high salt tolerance of Spartina alterniflora.
Plant Physiology, 2023 High salt stress continues to challenge the growth and survival of many plants. Alternative polyadenylation (APA) produces mRNAs with different 3'-untranslated regions (3' UTRs) to regulate gene expression at the post-transcriptional level.
Taotao Wang +8 more
semanticscholar +1 more source