Results 31 to 40 of about 669,618 (310)

Dehydration stress extends mRNA 3' untranslated regions with noncoding RNA functions in Arabidopsis. [PDF]

Genome Res, 2017
The 3′ untranslated regions (3′ UTRs) of mRNAs play important roles in the regulation of mRNA localization, translation, and stability. Alternative cleavage and polyadenylation (APA) generates mRNAs with different 3′ UTRs, but the involvement of this ...
Sun HX, Li Y, Niu QW, Chua NH.
europepmc   +2 more sources

A Novel Distinct Genetic Variant of Tomato Torrado Virus with Substantially Shorter RNA1-Specific 3’Untranslated Region (3’UTR)

Plants, 2021
Tomato torrado virus (ToTV) induces severe systemic necrosis in Solanum lycopersicum. This work aimed at describing the genetic variability of necrosis-inducing ToTV-Wal’17 collected in 2017, derived from the ToTV-Wal’03 after long-term passages in ...
Marta Budziszewska, Przemysław Wieczorek   +1 more
doaj   +1 more source

The 3' untranslated regions of influenza genomic sequences are 5'PPP-independent ligands for RIG-I. [PDF]

PLoS ONE, 2012
Retinoic acid inducible gene-I (RIG-I) is a key regulator of antiviral immunity. RIG-I is generally thought to be activated by ssRNA species containing a 5'-triphosphate (PPP) group or by unphosphorylated dsRNA up to ~300 bp in length. However, it is not
William G Davis, J Bradford Bowzard, Suresh D Sharma, Mayim E Wiens, Priya Ranjan, Shivaprakash Gangappa, Olga Stuchlik, Jan Pohl, Ruben O Donis, Jacqueline M Katz, Craig E Cameron, Takashi Fujita, Suryaprakash Sambhara   +12 more
doaj   +1 more source

Characterization of Single Nucleotide Variants of OPN3 Gene in Melanocytic Nevi and Melanoma

JID Innovations, 2021
In this study, we examined single nucleotide variants (SNVs) of the OPN3 gene in malignant melanoma and melanocytic nevi. A total of 20 variants of SNVs were detected.
Wei Zhang, Jianglong Feng, Wen Zeng, Zhixu Zhou, Yu Wang, Hongguang Lu   +5 more
doaj   +1 more source

Regulation of CCN1 via the 3′-untranslated region [PDF]

Journal of Cell Communication and Signaling, 2013
The 3'-untranslated region (UTR) is known to be a critical regulator of post-transcriptional events that determine the gene expression at the RNA level. The gene CCN1 is one of the classical members of the matricellular CCN family and is involved in a number of biological processes during mammalian development.
Yosuke, Nakagawa, Masanao, Minato, Kumi, Sumiyoshi, Aya, Maeda, Chikako, Hara, Yurika, Murase, Takashi, Nishida, Satoshi, Kubota, Masaharu, Takigawa   +8 more
openaire   +2 more sources

Alternative Polyadenylation in Human Diseases [PDF]

Endocrinology and Metabolism, 2017
Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing.
Jae-Woong Chang, Hsin-Sung Yeh, Jeongsik Yong   +2 more
doaj   +1 more source

Transcriptional Repression, a Novel Function for 3' Untranslated Regions [PDF]

European Journal of Biochemistry, 1995
The transcription rates of the rat serine protease inhibitor 2.3 and 2.1 genes (spi 2.3 and spi 2.1), which are normally very low and high, respectively, are inversely modulated during inflammation. Two growth‐hormone‐response elements (GHRE‐I and GHRE‐II) maintain the spi 2.1 gene under the stringent control of growth hormone [Le Cam, A., Pantescu, V.,
A, Le Cam, C, Legraverend
openaire   +3 more sources

The ODC 3′-Untranslated Region and 5′-Untranslated Region Contain cis-Regulatory Elements: Implications for Carcinogenesis [PDF]

Medical Sciences, 2017
It has been hypothesized that both the 3′-untranslated region (3′UTR) and the 5′-untranslated region (5′UTR) of the ornithine decarboxylase (ODC) mRNA influence the expression of the ODC protein. Here, we use luciferase expression constructs to examine the influence of both UTRs in keratinocyte derived cell lines. The ODC 5′UTR or 3′UTR was cloned into
Shannon L. Nowotarski, Lisa M. Shantz
openaire   +3 more sources

Erythrocyte complement receptor 1 (CR1) expression level is not associated with polymorphisms in the promoter or 3' untranslated regions of the CR1 gene [PDF]

, 2006
Complement receptor 1 (CR1) expression level on erythrocytes is genetically determined and is associated with high (H) and low (L) expression alleles identified by a HindIII restriction fragment-length polymorphism (RFLP) in intron 27 of the CR1 gene ...
Cockburn I.A., Cockburn I.A., Funkhouser T., Kim J.H., Moulds J.M., Rowe J.A., Tournamille C., Vik D.P., Xiang L.   +8 more
core   +1 more source

A novel class of microRNA-recognition elements that function only within open reading frames. [PDF]

, 2018
MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby silencing gene expression at the post-transcriptional level.
A Aizer, A Helwak, A Jakymiw, A Lal, AE Pasquinelli, AJ Giraldez, Alexander Dobin, AM Duursma, AR Buskirk, AR Quinlan, B Langmead, Bing Zhou, CJ Decker, CJ Shoemaker, CJ Woolstenhulme, CP Petersen, Dehe Wang, DP Bartel, DT Humphreys, E Huntzinger, EL Nostrand Van, GB Loeb, Guangqiao Liu, H Guo, HA Meijer, HO Iwakawa, I Behm-Ansmant, I Elcheva, J Hausser, J Liu, J Liu, JH Kim, Jie Zhou, JJ Forman, JP Broughton, K Seggerson, KA O’Donnell, Kai Zhang, L Wu, Ligang Wu, M Hafner, M Kouwenhove van, M Rehmsmeier, MD Robinson, MK Doma, ML Donnelly, N Rajewsky, NT Schirle, PA Maroney, Qian Zhao, R Ishimura, R Ishimura, R Parker, Ran Cao, RS Pillai, S Bagga, S Djuranovic, S Grosswendt, S Gu, S Jonas, S Nottrott, S Takagi, SN Bhattacharyya, SW Chi, SW Eichhorn, Timothy Nilsen, TT Tat, V Presnyak, W Filipowicz, Wen Ruan, X Adiconis, Xiang-Dong Fu, Xiaorong Zhang, Y Ishigaki, Y Liao, Y Tay, Y Wang, Y Xue, Y Zhao, Ya Zhao, Yan Qin, Yu Zhou, Yuanchao Xue, Z Cai, Zhiqiang Cai, Zonggui Chen   +85 more
core   +2 more sources