Results 51 to 60 of about 669,618 (310)

Cooperativity between the preproinsulin mRNA untranslated regions Is necessary for glucose-stimulated translation [PDF]

, 2001
Glucose regulates proinsulin biosynthesis via stimulation of the translation of the preproinsulin mRNA in pancreatic β-cells. However, the mechanism by which this occurs has remained unclear.
Alarcon, Alarcon, Barton Wicksteed, Becker, Christopher J. Rhodes, Cristina Alarcon, Decker, Docherty, Dodson, Gilligan, Goodge, Grimaldi, Guest, Guest, Herbert, Hsu, Itoh, Knight, Kozak, Larry G. Moss, Leer, Martin, Melissa K. Lingohr, Rhoads, Rhodes, Rouault, Sachs, Schppin, Seglen, Skelly, Terence P. Herbert, Webb, Welsh, Welsh, Xu   +34 more
core   +1 more source

Variants of the low oxygen sensors EGLN1 and HIF-1AN associated with acute mountain sickness. [PDF]

, 2014
Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-α inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1α, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS).
Huang, Lan, Jin, Jun, Li, Huijie, Qin, Jun, Zhang, Enhao, Zhang, Jihang   +5 more
core   +3 more sources

Metabolite-dependent regulation of gene expression in trypanosoma brucei [PDF]

, 2013
Mechanisms regulating gene expression in trypanosomatid protozoa differ significantly from those in other eukaryotes. Transcription of the genome appears to be more or less constitutive with the polyadenylation and trans-splicing of large polycistronic ...
Archer, Batey, Besteiro, Birkholtz, Breaker, Carter, Clayton, Coustou, De Gaudenzi, Ebikeme, Fairlamb, Hendriks, Jacob, Jensen, Kabani, Lamour, Mangold, Martinez-Calvillo, Nguyen, Perez-Leal, Persson, Phillips, Stuart, Veitch, Vincent, Ward, Willert, Willert, Willert, Wirtz, Wurst, Wurst, Xiao, Xiao, Zhang   +34 more
core   +1 more source

Detection of novel 3' untranslated region extensions with 3' expression microarrays [PDF]

BMC Genomics, 2010
Abstract Background The 3' untranslated regions (UTRs) of transcripts are not well characterized for many genes and often extend beyond the annotated regions. Since Affymetrix 3' expression arrays were designed based on expressed sequence tags, many probesets map to intergenic regions downstream of genes.
Thorrez, Lieven, Tranchevent, Léon-Charles, Chang, H.J., Moreau, Yves, Schuit, Frans   +4 more
openaire   +4 more sources

Alternative polyadenylation and polymorphisms of 3'untranslated regions of bovine BBOX1 gene

Czech Journal of Animal Science, 2018
l-Carnitine, a key element in fatty acid metabolism and energy production, is biosynthesized from gamma-butyro-betaine by the catalysis of gamma-butyrobetaine hydroxylase (BBOX1).
Guo-Li Zhou, Yang Cao, You-Zhi Xin, Yu-Fei Song, Hai-Guo Jin   +4 more
doaj   +1 more source

3' Untranslated regions mediate transcriptional interference between convergent genes both locally and ectopically in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2014
Paired sense and antisense (S/AS) genes located in cis represent a structural feature common to the genomes of both prokaryotes and eukaryotes, and produce partially complementary transcripts.
Luwen Wang, Ning Jiang, Lin Wang, Ou Fang, Lindsey J Leach, Xiaohua Hu, Zewei Luo   +6 more
doaj   +1 more source

A genome-wide scan for microrna-related genetic variants associated with primary open-angle glaucoma [PDF]

, 2017
PURPOSE: To identify microRNAs (miRNAs) involved in primary open-angle glaucoma (POAG), using genetic data. MiRNAs are small noncoding RNAs that posttranscriptionally regulate gene expression. Genetic variants in miRNAs or miRNA-binding sites within gene
Dehghan, A. (Abbas), Duijn, C.M. (Cornelia) van, Erkeland, S.J. (Stefan), Ghanbari, M. (Mohsen), Iglesias, A.I. (Adriana I.), Ikram, M.K. (Kamran), Klaver, C.C.W. (Caroline), Meester-Smoor, M.A. (Magda), Springelkamp, H. (Henriët)   +8 more
core   +1 more source

Translational control of mRNAs by 3'-Untranslated region binding proteins [PDF]

BMB Reports, 2017
Eukaryotic gene expression is precisely regulated at all points between transcription and translation. In this review, we focus on translational control mediated by the 3'-untranslated regions (UTRs) of mRNAs. mRNA 3'-UTRs contain cis-acting elements that function in the regulation of protein translation or mRNA decay.
Yamashita, Akio, Takeuchi, Osamu
openaire   +2 more sources

Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. [PDF]

, 2013
The 3' untranslated region (3'UTR) of hepatitis C virus (HCV) messenger RNA stimulates viral translation by an undetermined mechanism. We identified a high affinity interaction, conserved among different HCV genotypes, between the HCV 3'UTR and the host ...
Bai, Yun, Doudna, Jennifer A, Zhou, Kaihong   +2 more
core   +2 more sources

Mapping the Pax6 3’ untranslated region microRNA regulatory landscape

BMC Genomics, 2018
PAX6 is a homeodomain transcription factor that acts in a highly dosage-sensitive manner to regulate the development and function of the eyes, nose, central nervous system, gut, and endocrine pancreas. Several individual microRNAs (miRNA) have been implicated in regulating PAX6 in different cellular contexts, but a more general view of how they ...
Bridget C. Ryan, Kieran Lowe, Laura Hanson, Talveen Gil, Lauren Braun, Perry L. Howard, Robert L. Chow   +6 more
openaire   +3 more sources