Results 41 to 50 of about 916,340 (306)

A Three-Dimensional Co-Culture Model for Rheumatoid Arthritis Pannus Tissue

Frontiers in Bioengineering and Biotechnology, 2021
Three-dimensional (3D) co-culture models have closer physiological cell composition and behavior than traditional 2D culture. They exhibit pharmacological effects like in vivo responses, and therefore serve as a high-throughput drug screening model to ...
Jietao Lin, Jietao Lin, Jietao Lin, Antonia RuJia Sun, Antonia RuJia Sun, Antonia RuJia Sun, Jian Li, Jian Li, Jian Li, Tianying Yuan, Wenxiang Cheng, Wenxiang Cheng, Wenxiang Cheng, Liqing Ke, Liqing Ke, Liqing Ke, Jianhai Chen, Jianhai Chen, Jianhai Chen, Wei Sun, Shengli Mi, Peng Zhang, Peng Zhang, Peng Zhang   +23 more
doaj   +1 more source

Enhanced differentiation of human pluripotent stem cells into pancreatic endocrine cells in 3D culture by inhibition of focal adhesion kinase

Stem Cell Research & Therapy, 2020
Background Generation of insulin-producing cells from human pluripotent stem cells (hPSCs) in vitro would be useful for drug discovery and cell therapy in diabetes.
Xiaofang Liu, Jinhua Qin, Mingyang Chang, Shuyong Wang, Yali Li, Xuetao Pei, Yunfang Wang   +6 more
doaj   +1 more source

Data of a fluorescent imaging-based analysis of anti-cancer drug effects on three-dimensional cultures of breast cancer cells

Data in Brief, 2015
Three-dimensional (3D) cell culture is a powerful tool to study cell growth under 3D condition. To perform a simple test for anti-cancer drugs in 3D culture, visualization of non-proliferated cells is required.
Junji Itou, Sunao Tanaka, Wenzhao Li, Yoshiaki Matsumoto, Fumiaki Sato, Masakazu Toi   +5 more
doaj   +1 more source

Multiple cystic sphere formation from PK-8 cells in three-dimensional culture

Biochemistry and Biophysics Reports, 2022
Three-dimensional (3D) culture of cancer cells mimics the in vivo environment. Recently, we reported that pancreatic ductal adenocarcinoma (PDAC) cell lines with epithelial and mesenchymal features formed differently shaped spheres in 3D culture. However,
Yuuki Shichi, Fujiya Gomi, Yoshibumi Ueda, Keisuke Nonaka, Fumio Hasegawa, Yasuko Hasegawa, Nae Hinata, Hisashi Yoshimura, Masami Yamamoto, Kimimasa Takahashi, Tomio Arai, Toshiyuki Ishiwata   +11 more
doaj   +1 more source

Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation [PDF]

, 2018
Mesenchymal stem cells play a vital role in bone formation process by differentiating into osteoblasts, in a tissue that offers not a flat but a discontinuous three-dimensional (3D) topography in vivo. In order to understand how geometry may be affecting
Bidan CM, David M Grant, Dhanak Gupta, Florencio-Silva R, Ifty Ahmed, Kazi M Zakir Hossain, Kliment CR, Petrie RJ, Teitelbaum SL, Virginie Sottile, Werner M   +10 more
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Deterministic culturing of single cells in 3D [PDF]

Scientific Reports, 2020
AbstractModels using 3D cell culture techniques are increasingly accepted as the most biofidelic in vitro representations of tissues for research. These models are generated using biomatrices and bulk populations of cells derived from tissues or cell lines. We present an alternate method to culture individually selected cells in relative isolation from
Rohil Jain, Shirisha Chittiboyina, Chun-Li Chang, Sophie A. Lelièvre, Cagri A. Savran   +4 more
openaire   +3 more sources

Organotypic 3D Cell-Architecture Impacts the Expression Pattern of miRNAs–mRNAs Network in Breast Cancer SKBR3 Cells

Non-Coding RNA, 2023
Background. Currently, most of the research on breast cancer has been carried out in conventional two-dimensional (2D) cell cultures due to its practical benefits, however, the three-dimensional (3D) cell culture is becoming the model of choice in cancer
María de los Ángeles Gastélum-López, Maribel Aguilar-Medina, Cristina García Mata, Jorge López-Gutiérrez, Geovanni Romero-Quintana, Mercedes Bermúdez, Mariana Avendaño-Felix, César López-Camarillo, Carlos Pérez-Plascencia, Adriana S Beltrán, Rosalío Ramos-Payán   +10 more
doaj   +1 more source

Mass spectrometry imaging of 3D tissue models [PDF]

, 2018
A 3D cell culture is an artificially created environment in which cells are permitted to grow/interact with their surroundings in all three dimensions.
Clench, Malcolm, Flint, Lucy, Lewis, Emily, Russo, Cristina   +3 more
core   +1 more source

3D Cell Culture Models of Epithelial Tissues [PDF]

, 2019
Cells in tissues in vivo face a very different microenvironment than typical cultured cells plated on a plastic dish. Already several decades ago, cell biologists observed that cell lines show dramatically different morphology and growth characteristics when embedded into three-dimensional (3D) substrates or standard tissue culture plates (Montesano R,
Manninen Aki, Zhang Kai
openaire   +3 more sources

Development of a novel 3D culture system for screening features of a complex implantable device for CNS repair [PDF]

, 2013
Tubular scaffolds which incorporate a variety of micro- and nanotopographies have a wide application potential in tissue engineering especially for the repair of spinal cord injury (SCI).
Bereiter-Hahn J., Casey B. G., Cavaglia M., Chary S. R., Clark P., Csaderova L., Gadegaard N., Gadegaard N., Gailit J., Gilbert R. J., Huh D., Lakatos A., Mathis O. Riehle, Mirastschijski U., Nikolaj Gadegaard, Noble M., Peter S. Donoghue, Robert P., Ruff R. L., Salem A. K., Sarkar S., Seunarine K., Sun T., Sun T., Sun T., Susan C. Barnett, Sørensen A., Sørensen A., Tao Sun, Thomson C. E., Van Harreveld A., Yamada M.   +31 more
core   +3 more sources