Results 21 to 30 of about 186,280 (286)

TADs are 3D structural units of higher-order chromosome organization in Drosophila [PDF]

Science Advances, 2018
Drosophila chromosomes are organized in a series of nanocompartments that correspond to topologically associating domains.
Szabo, Quentin, Jost, Daniel, Chang, Jia-Ming, Cattoni, Diego I., Papadopoulos, Giorgio L., Bonev, Boyan, Sexton, Tom, Gurgo, Julian, Jacquier, Caroline, Nollmann, Marcelo, Bantignies, Frédéric, Cavalli, Giacomo   +11 more
openaire   +3 more sources

Heterogeneous loop model to infer 3D chromosome structures from Hi-C [PDF]

Biophysical Journal, 2019
Adapting a well-established formalism in polymer physics, we develop a minimalist approach to infer threedimensional (3D) folding of chromatin from Hi-C data. The 3D chromosome structures generated from our heterogeneous loop model (HLM) are used to visualize chromosome organizations that can substantiate the measurements from FISH ...
Liu, Lei, Kim, Min Hyeok, Hyeon, Changbong   +2 more
openaire   +2 more sources

Application of Hi-C and other omics data analysis in human cancer and cell differentiation research

Computational and Structural Biotechnology Journal, 2021
With the development of 3C (chromosome conformation capture) and its derivative technology Hi-C (High-throughput chromosome conformation capture) research, the study of the spatial structure of the genomic sequence in the nucleus helps researchers ...
Haiyan Gong, Yi Yang, Sichen Zhang, Minghong Li, Xiaotong Zhang   +4 more
doaj   +1 more source

Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing [PDF]

, 2016
The Xist long noncoding RNA orchestrates X chromosome inactivation, a process that entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure of the X chromosome.
Aznauryan, Erik, Blanco, Mario, Cerase, Andrea, Chen, Chun-Kan, Chow, Amy, Guttman, Mitchell, Jackson, Costanza, McDonel, Patrick, Ollikainen, Noah, Surka, Christine   +9 more
core   +1 more source

Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome. [PDF]

PLoS Genetics, 2016
Assembly of kinetochore complexes, involving greater than one hundred proteins, is essential for chromosome segregation and genome stability. Neocentromeres, or new centromeres, occur when kinetochores assemble de novo, at DNA loci not previously ...
Laura S Burrack, Hannah F Hutton, Kathleen J Matter, Shelly Applen Clancey, Ivan Liachko, Alexandra E Plemmons, Amrita Saha, Erica A Power, Breanna Turman, Mathuravani Aaditiyaa Thevandavakkam, Ferhat Ay, Maitreya J Dunham, Judith Berman   +12 more
doaj   +1 more source

Differences of size and shape of active and inactive X-chromosome domains in human amniotic fluid cell nuclei [PDF]

, 1993
It is a widely held belief that the inactive X-chromosome (Xi) in female cell nuclei is strongly condensed as compared to the largely decondensed active X-chromosome (Xa).
Barr, Brakenhoff, Brakenhoff, Collins, Comings, Cremer, Cremer, Cremer, Cremer, Cremer, Dyer, Dyer, Gartler, Geiger, Grumbach, Hens, Johnson, Krystosek, Leitch, Lichter, Lyon, Manuelidis, Morton, Ohno, Pinkel, Pinkel, Popp, Rosenfeld, Schardin, Shotton, Stelzer, Stelzer, Taylor, Therman, Therman, van Dekken, Visser, Vogel, Walker, Zorn   +39 more
core   +1 more source

Use of 3D imaging for providing insights into high-order structure of mitotic chromosomes [PDF]

Chromosoma, 2018
The high-order structure of metaphase chromosomes remains still under investigation, especially the 30-nm structure that is still controversial. Advanced 3D imaging has provided useful information for our understanding of this detailed structure. It is evident that new technologies together with improved sample preparations and image analyses should be
Mohammed Yusuf, Kohei Kaneyoshi, Kiichi Fukui, Ian Robinson   +3 more
openaire   +4 more sources

Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores at meiosis I [PDF]

, 2013
Sexually reproducing organisms halve their cellular ploidy during gametogenesis by undergoing a specialized form of cell division known as meiosis. During meiosis, a single round of DNA replication is followed by two rounds of nuclear divisions (referred
A Petrovic, A Toth, AL Marston, AP Joglekar, C Michaelis, C Rumpf, E Screpanti, Eva Hoffmann, GW Kerr, GW Kerr, IL Brito, J Fernius, J Gregan, J Huang, J Matos, J Wong, Jacob Z. Dalgaard, Jonathan B. A. Millar, K Johzuka, K Tada, K Tanaka, KD Corbett, KD Corbett, KP Rabitsch, Louise Newnham, M Petronczki, M Petronczki, MR Przewloka, N Grandin, P Hieter, P Hornung, Prakash Arumugam, Rajesh T. Shenoy, RK Clyne, S Keeney, S Santaguida, S Westermann, SB Buonomo, Sourav Sarkar, Sue Biggins, X Li   +40 more
core   +11 more sources

The architecture of chicken chromosome territories changes during differentiation [PDF]

, 2004
BACKGROUND: Between cell divisions the chromatin fiber of each chromosome is restricted to a subvolume of the interphase cell nucleus called chromosome territory.
Bonifer, C., Cremer, C., Cremer, T., Dietzel, S., Mayer, R., Schnapp, V., Stadler, S., Stein, S.   +7 more
core   +4 more sources

Development of Deletion Lines for Chromosome 3D of Bread Wheat

Frontiers in Plant Science, 2020
The identification of genes of agronomic interest in bread wheat (Triticum aestivum L.) is hampered by its allopolyploid nature (2n = 6x = 42; AABBDD) and its very large genome, which is largely covered by transposable elements.
Radim Svačina, Miroslava Karafiátová, Magdaléna Malurová, Heïdi Serra, Dominik Vítek, Takashi R. Endo, Pierre Sourdille, Jan Bartoš   +7 more
doaj   +1 more source