Results 51 to 60 of about 8,821,447 (199)
X Inactivation and Escape: Epigenetic and Structural Features
Frontiers in Cell and Developmental Biology, 2019 X inactivation represents a complex multi-layer epigenetic mechanism that profoundly modifies chromatin composition and structure of one X chromosome in females.
He Fang +3 more
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Deciphering the molecular mechanism of the cancer formation by chromosome structural dynamics.
PLoS Computational Biology, 2021 Cancer reflects the dysregulation of the underlying gene network, which is strongly related to the 3D genome organization. Numerous efforts have been spent on experimental characterizations of the structural alterations in cancer genomes.
Xiakun Chu, Jin Wang
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High-resolution 3D models of Caulobacter crescentus chromosome reveal genome structural variability and organization [PDF]
Nucleic Acids Research, 2018 High-resolution three-dimensional models of Caulobacter crescentus nucleoid structures were generated via a multi-scale modeling protocol. Models were built as a plectonemically supercoiled circular DNA and by incorporating chromosome conformation capture based data to generate an ensemble of base pair resolution models consistent with the experimental
Asli Yildirim, Michael Feig
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Genome Biology, 2023 Background DNA double-strand breaks (DSBs) are among the most deleterious DNA lesions, and they can cause cancer if improperly repaired. Recent chromosome conformation capture techniques, such as Hi-C, have enabled the identification of relationships ...
Yu Sun +16 more
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Chromosome Centromeres: Structural and Analytical Investigations with High Resolution Scanning Electron Microscopy in Combination with Focused Ion Beam Milling [PDF]
, 2009 Whole mount mitotic metaphase chromosomes of different plants and animals were investigated with high resolution field emission scanning electron microscopy (FESEM) to study the ultrastructural organization of centromeres, including metacentric ...
Schroeder-Reiter, E., Wanner, Gerhard
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[Logiciel] Open source 3D viewer
, 2021 "Voyager is part of the Smithsonian’s Digitization Program Office’s 3D foundation pipeline.
Consortium 3D SHS Team
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Frontiers in Plant Science, 2014 The nuclear envelope (NE) plays an essential role in meiotic telomere behavior and links the cytoplasm and nucleoplasm during homologous chromosome pairing and recombination in many eukaryotic species.
Shaun Patrick Murphy +4 more
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Nature Communications, 2022 ABSTRACT The principles that govern the organization of genomes, which are needed for a deeper understanding of how chromosomes are packaged and function in eukaryotic cells, could be deciphered if the three dimensional (3D) structures are known. Recently, single-cell imaging experiments have determined the 3D coordinates of a number of
Guang Shi, D. Thirumalai
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Modelling chromosome-wide target search
New Journal of Physics, 2023 The most common gene regulation mechanism is when a transcription factor (TF) protein binds to a regulatory sequence to increase or decrease RNA transcription. However, TFs face two main challenges when searching for these sequences. First, the sequences
Lucas Hedström, Ludvig Lizana
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, 2020 " 3DHOP (3D Heritage Online Presenter) is an open-source software package for the creation of interactive Web presentations of high-resolution 3D models, oriented to the Cultural Heritage field....
Consortium 3D SHS Team
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