Results 61 to 70 of about 186,280 (286)

Delta integrates 3D physical structure with topology and genomic data of chromosomes [PDF]

, 2017
Abstract Motivation The regulation of gene transcription and DNA replication are tightly associated with the 3D chromosomal structures and genomic features, e.g. epigenetic marks, transcription factor bindings and non-coding RNAs.
Tang, Bixia, Li, Feifei, Li, Jing, Zhao, Wenming, Zhang, Zhihua   +4 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. [PDF]

, 2018
Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches.
Castillo-Azofeifa, David, Delling, Markus, Klein, Ophir D, McKinley, Kara L, Royer, Loic A, Schartner, Christoph, Stuurman, Nico, Vale, Ronald D   +7 more
core   +1 more source

EVRC: Reconstruction of chromosome 3D structure models using Error-Vector Resultant algorithm with Clustering coefficient

Bioinformatics, 2023
Abstract Reconstruction of 3D structure models is of great importance for the study of chromosome function. In this paper, we present a novel reconstruction algorithm, called EVRC, which utilizes co-clustering coefficients and error-vector resultant for chromosome 3D structure reconstruction.
Xiao Wang, Wei-Cheng Gu, Jie Li, Bin-Guang Ma   +3 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Deciphering the molecular mechanism of the cancer formation by chromosome structural dynamics.

PLoS Computational Biology, 2021
Cancer reflects the dysregulation of the underlying gene network, which is strongly related to the 3D genome organization. Numerous efforts have been spent on experimental characterizations of the structural alterations in cancer genomes.
Xiakun Chu, Jin Wang
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Evolutionary patterns and functional effects of 3D chromatin structures in butterflies with extensive genome rearrangements

Nature Communications
Chromosome rearrangements may distort 3D chromatin architectures and thus change gene regulation, yet how 3D chromatin structures evolve in insects is largely unknown.
Botong Zhou, Ping Hu, Guichun Liu, Zhou Chang, Zhiwei Dong, Zihe Li, Yuan Yin, Zunzhe Tian, Ge Han, Wen Wang, Xueyan Li   +10 more
doaj   +1 more source

X Inactivation and Escape: Epigenetic and Structural Features

Frontiers in Cell and Developmental Biology, 2019
X inactivation represents a complex multi-layer epigenetic mechanism that profoundly modifies chromatin composition and structure of one X chromosome in females.
He Fang, Christine M. Disteche, Christine M. Disteche, Joel B. Berletch   +3 more
doaj   +1 more source

The dynamics of genome replication using deep sequencing [PDF]

, 2013
Peer reviewedPublisher ...
Agier, Alessandro P.S. de Moura, Alvino, Besnard, Bouton, Breier, Carolin A. Müller, Celniker, Chang, Conrad A. Nieduszynski, Cosgrove, Crampton, de Moura, De Piccoli, Di Rienzi, Eaton, Feng, Friedman, Gilbert, Hoggard, Huang, Katsuhiko Shirahige, Kearsey, Knott, Knott, Koren, Koren, Liachko, Lian, Makiko Komata, Martin J. Blythe, McGuffee, Mechali, Mechali, Mesner, Michelle Hawkins, Muller, Nakato, Natsume, Newman, Ng, Nieduszynski, Palzkill, Raghuraman, Ray Wilson, Renata Retkute, Retkute, Retkute, Rhind, Rudolph, Ryuichiro Nakato, Sekedat, Sharma, Shirahige, Siow, Sunir Malla, Theis, Theis, Theis, Vujcic, Xu, Xu, Yabuki, Yamashita, Yoshikawa   +64 more
core   +3 more sources