Results 131 to 140 of about 4,897,037 (304)

Gene expression profile in 3T3-A212P and 3T3-CON cells.

, 2013
(A) The heat map plots of the genes in the biological functions changed in the 3T3-A212P cells. The output of Agilent data was analyzed by using Partek Genome suite.
Kenneth Wee (387154), Wenjie Qiu (387153), Xuemei Lim (387156), George K. Radda (198986), Weiping Han (198991), Kosuke Takeda (387155), Shigeki Sugii (387157)   +6 more
core   +1 more source

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

Oncogenic transformation of NIH/3T3 cells by the overexpression of L-type amino acid transporter 1, a promising anti-cancer target. [PDF]

Oncotarget, 2021
Hayashi N, Yamasaki A, Ueda S, Okazaki S, Ohno Y, Tanaka T, Endo Y, Tomioka Y, Masuko K, Masuko T, Sugiura R.   +10 more
europepmc   +1 more source

Induction of eIF4E in NIH 3T3 fibroblast cells and microarray analysis.

, 2013
A) eIF4E overexpression was induced by culturing 3T3-tTA-eIF4E cells in a tetracycline free medium. Immunoblots for eIF4E and β-actin were performed. B) A characteristic fractionation profile of 3T3-tTA and 3T3-tTA-eIF4E cells is depicted.
Taka-Aki Sato (68690), Yaël Mamane (68687), Ola Larsson (15776), Vinagolu K. Rajasekhar (68691), Nahum Sonenberg (68692), Yvan Martineau (68689), Emmanuel Petroulakis (68688)   +6 more
core   +1 more source

Advanced In Vitro Platforms for Experimental Liver Research: From Organoids and Liver‐on‐Chip to Omics and Artificial Intelligence

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Hepatocytes perform essential physiological functions in the human body. Gaining more profound insight into the liver structure, diseases, and physiology by using in vitro models can help to propose more relevant clinical applications. Conventional in vitro liver models, such as two‐dimensional (2D) cell cultures, fail to adequately replicate ...
Seyedeh Kiana Teymorian, Pedram Asadi Sarabi, Abbas Piryaei, Massoud Vosough   +3 more
wiley   +1 more source

C/EBPα was not required for adipogenesis in NIH/3T3 cells.

, 2013
(A) The whole cell culture dish view in panel (A) and micrographs in panel (B) of the oil red O staining of 3T3-L1 (L1) and NIH/3T3 (NIH) cells induced after the cells were infected with lentiviruses expressing shRNA targeting luciferase (Luc), C/EBPα ...
Hsiao-Yun Shao (289558), Hsue-Yin Hsu (289559), Lee-Ming Chuang (215892), Kuan-Sju Wu (289560), Siow-Wey Hee (289561), Jih-I Yeh (289562)   +5 more
core   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Homologous tumor‐targeting biomimetic nanozyme for synergistic NIR‐II photothermal and chemodynamic therapy

BMEMat, EarlyView.
Studies reveal that a biomimetic nanoplatform based on a cancer cell membrane‐camouflaged Au‐MnOx nanozyme (Au‐MnOx@CCM) can achieve synergistic antitumor therapy by combining NIR‐II mediated PTT with enhanced CDT, offering a promising strategy for precise and efficient tumor therapy. Abstract The therapeutic potential of nanozyme‐mediated chemodynamic
Xiaonan Li, Siman Luo, Yucheng Zuo, Liheng Chen, Houjuan Zhu, Jing‐Yi Zhu, Wei Xue   +6 more
wiley   +1 more source

Assessment of Adipocyte Transduction Using Different AAV Capsid Variants

Pharmaceuticals
Background/Objectives: Adeno-associated viruses (AAVs) are widely used as viral vectors for gene delivery in mammalian cells. We focused on the efficacy of the transduction of AAV2/5, 2/6, 2/8 and 2/9 expressing GFP in preadipocyte cells by live imaging ...
Stanislav Boychenko, Alina Abdullina, Viktor S. Laktyushkin, Andrew Brovin, Alexander D. Egorov   +4 more
doaj   +1 more source

Differentiation-dependent expression and release of CXCL2 in 3T3-L1 cells.

, 2016
NIH 3T3 fibroblasts and 3T3-L1 pre-adipocytes were cultured in differentiation medium (DIFF) or remained undifferentiated (ND) in control medium (DMEM) for 12 days. At day 12, differentiated (DIFF) and non-differentiated (ND) 3T3-L1 cells were stimulated
Stefan Frank (148010), Anna Siebert (3592427), Itamar Goren (239736), Josef Pfeilschifter (92946)   +3 more
core   +1 more source