Results 51 to 60 of about 775 (125)
Interdisciplinary Medicine, EarlyView.In normal pregnancy, PEVs help maintain maternal–fetal immune tolerance while enabling controlled immune activation, promote endothelial migration, and support trophoblast invasion and syncytialization, strengthening antimicrobial defense. In pregnancy‐related disorders, dysregulated PEV signaling may drive endothelial dysfunction and hypertension, BBB
Jiale Du +5 more
wiley +1 more source
Pharmacological ResearchPerturbed cholesterol metabolism may play an important role in the development of dementia and its preclinical stage, mild cognitive impairment (MCI). Oxysterols, the metabolites generated during cholesterol oxidation, also appear to be risk factors for ...
Yu An +9 more
doaj +1 more source
Early or deferred initiation of efavirenz during rifampicin‐based TB therapy has no significant effect on CYP3A induction in TB‐HIV infected patients [PDF]
, 2020 Background and Purpose: In TB‐HIV co‐infection, prompt initiation of TB therapy is recommended but anti‐retroviral treatment (ART) is often delayed due to potential drug–drug interactions between rifampicin and efavirenz.
Aklillu, E +7 more
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Medical and Veterinary Entomology, EarlyView.Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre +7 more
wiley +1 more source
Redox Biology, 2016 Alzheimer's disease (AD) is a gradually debilitating disease that leads to dementia. The molecular mechanisms underlying AD are still not clear, and at present no reliable biomarkers are available for the early diagnosis.
Gabriella Testa +9 more
doaj +1 more source
Elevated acute phase proteins affect pharmacokinetics in COVID-19 trials: Lessons from the CounterCOVID - imatinib study. [PDF]
, 2021 This study aimed to determine whether published pharmacokinetic (PK) models can adequately predict the PK profile of imatinib in a new indication, such as coronavirus disease 2019 (COVID-19).
Aman, J. +14 more
core +3 more sources
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Maria H. Ahonen +5 more
wiley +1 more source
Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Antolin Canto +6 more
wiley +1 more source
Translational aspects of drug metabolism in inflammation and disease [PDF]
, 2022 Lægemidler udgør fundamentet i behandlingen af de fleste medicinske sygdomme. Enudfordring ved behandling med lægemidler er, at der kan være stor forskel i effekt ogbivirkninger blandt patienter.
Dunvald, Ann-Cathrine Dalgård
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Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes
Advanced Science, Volume 13, Issue 13, 3 March 2026.Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Bright Asare‐Bediako +16 more
wiley +1 more source