Results 61 to 70 of about 775 (125)
Clinical &Translational Immunology, Volume 15, Issue 3, 2026.This study developed a prognostic model for lung adenocarcinoma using manganese metabolism‐related genes (MRGs). Nine key MRGs were identified via multi‐omics and LASSO‐Cox analyses to calculate a risk score. The model showed robust predictive performance in both training and validation cohorts.
Hongliang Li +4 more
wiley +1 more source
Hypertension in Overweight and Obesity: Sex‐Specific Role of 4β‐Hydroxycholesterol
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground We have previously proposed novel pathway in overweight/obesity‐induced hypertension involving plasma 4β‐hydroxycholesterol (4βHC), an agonist for LXR (liver X receptor), as a hypotensive factor.
Roosa Rahunen +4 more
doaj +1 more source
Journal of Lipid Research, 2012 We describe the development of a method for the extraction and analysis of 62 sterols, oxysterols, and secosteroids from human plasma using a combination of HPLC-MS and GC-MS. Deuterated standards are added to 200 μl of human plasma.
Jeffrey G. McDonald +3 more
doaj +1 more source
CYP3A4誘導能評価マーカー4β-hydroxycholesterolの医薬品開発への活用・実装に向けた研究 [PDF]
, 2023 Tohoku University博士（農学）博士学位論文 (Thesis(doctor ...
田谷, 有妃
core
Clinical and Translational Science, Volume 19, Issue 3, March 2026.ABSTRACT Coproporphyrin I (CPI) is increasingly recognized as a reliable endogenous biomarker for hepatic OATP1B transporters. However, confounding mechanisms such as increased heme biosynthesis driven by induction of CYP enzymes, which are hemoproteins, may affect CPI levels independently of OATP1B1 inhibition. The aim of this study was to investigate
Leila Potzel +5 more
wiley +1 more source
Advanced Science, Volume 13, Issue 10, 18 February 2026.By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi +18 more
wiley +1 more source
Impacts of genetic polymorphisms and cancer cachexia on naldemedine pharmacokinetics and bowel movements in patients receiving opioid analgesics [PDF]
浜松医科大学Hamamatsu University School of Medicine博士（医学）doctoral医学系研究科Background/Objectives: Clinical responses to naldemedine vary between individuals with advanced cancer.
Nakatsugawa, Emi +2 more
core +1 more source
Studies of drug disposition in hemodialysis patients : impact of genetics, inflammation and vitamin D [PDF]
, 2017 Chronic kidney disease (CKD) patients are at a high risk for drug adverse effects due to accumulation of drugs, which normally are excreted via the kidneys. It is believed that drugs that are metabolized by the liver are safe to prescribe in normal doses
Molanaei, Hadi
core +1 more source
Exploring mitochondrial cholesterol (mChol) signalling for therapeutic intervention in neurological conditions [PDF]
, 2019 The pharmacological targeting of cholesterol levels continues to draw interest due to the vast success of therapeutics such as statins in extending life expectancy by modifying the prognosis of diseases associated with the impairment of the lipid ...
Campanella, M, Desai, R
core +1 more source
MedComm, Volume 7, Issue 2, February 2026.Based on the integrated analysis of follicular fluid metabolites and microbial communities in patients with PCOS, this study reveals significant dysregulation in the follicular microenvironment. Key metabolites including D‐glucose and 25‐hydroxycholesterol show marked alterations, while microbial communities such as Alicyclobacillus and Terrimonas ...
Manfei Si +6 more
wiley +1 more source