Results 91 to 100 of about 85,474,312 (231)

Prescription Intervals of Medications for Chronic Use: A Cohort Study

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 11, November 2026.
ABSTRACT Purpose In deprescribing studies, a prescription‐free gap is typically used to determine if patients discontinued their treatment. An appropriate gap depends on the typical time between prescriptions during continued use. This work aims to characterise the interval between prescriptions of chronic drugs (long‐term use) using different methods ...
Ryan Muddiman, Padraic Donoghue, Jessica Gómez Lemus, Ann Sinéad Doherty, Fiona Boland, Caroline McCarthy, Frank Moriarty   +6 more
wiley   +1 more source

Synthesis of 4-Ethoxy-2,3-dihydropyridinium Tetrafluoroborate Salts and 4-Ethoxy-2,3-dihydropyridines

, 2009
Transformation of 2,3-dihydropyridones to 2,3-dihydropyridinium tetrafluoroborate salts and 2,3-dihydropyridines was accomplished using ethyl Meerwein’s ...
T. Jones, Jones, T. Nicholas, Cynthia McClure, T. Nicholas Jones, McClure, Cynthia K., Cynthia K. McClure   +5 more
core   +1 more source

Synthesis and evaluation of calcium channel antagonist activity of new 1, 4-dihydropyridines containing phenylamineimidazolyl substitute in guinea-pig ileal smooth muscle

Journal of Research in Medical Sciences, 2004
Background: 1,4-dihydropyridines are a class of drugs which are used in the treatment of some cardiovascular disorders. The prototype, Nifedipine, does not have optimal pharmacokinetic and pharmacodynamic properties.
A Fassihi, H Sadeghi, A Zarghi, A Shafiee   +3 more
doaj  

Relaxant Activity of 4H-Pyran and 1,6-Dihydropyridine Derivatives on Isolated Rat Trachea

Drugs and Drug Candidates
Derivatives of 4H-pyrans and 1,6-dihydropyridines have generated considerable attention due to their interesting biological and therapeutic values. Their pharmacological activities include vasorelaxant, anticarcinogenic, antimicrobial, and antioxidant ...
Samuel Estrada-Soto, Soledad Alemán-Pantitlán, Emmanuel Gaona-Tovar, Fernando Hernández-Borja, Yolanda Alcaraz, Rafael Villalobos-Molina, Miguel A. Vázquez   +6 more
doaj   +1 more source

Quantitative Structure-Activity Relationship Studies of 4-Imidazolyl- 1,4-dihydropyridines as Calcium Channel Blockers [PDF]

Iranian Journal of Basic Medical Sciences, 2013
Objective(s): The structure- activity relationship of a series of 36 molecules, showing L-type calcium channel blocking was studied using a QSAR (quantitative structure–activity relationship) method.
Farzin Hadizadeh, Saadat Vahdani, Mehrnaz Jafarpour   +2 more
doaj  

Dysglycaemia and Autonomic Dysfunction: The Diabetes Prevention Program Outcomes Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10743-10752, November 2026.
ABSTRACT Aim Limited data on the link between various measures of glycemia and metabolism and autonomic dysfunction exist. We assessed the association of fasting plasma glucose [FPG], glycated haemoglobin [HbA1C], fasting insulin, and HOMA‐IR and cardiac autonomic function measures separately for men and women in the Diabetes Prevention Program ...
Justin B. Echouffo‐Tcheugui, Xun Liu, Elsayed Z. Soliman, Xavier Pi‐Sunyer, Sherita H. Golden, Sam Dagogo‐Jack, Neil H. White, Matthew Budoff, Uzoma Ibebuogu, Christine Darwin, William C. Knowler, Marinella Temprosa, on behalf of the DPP Research Group   +12 more
wiley   +1 more source

Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines

Pharmaceutics, 2019
The design of nanoparticle delivery materials possessing biological activities is an attractive strategy for the development of various therapies. In this study, 11 cationic amphiphilic 4-(N-alkylpyridinium)-1,4-dihydropyridine (1,4-DHP) derivatives ...
Martins Rucins, Pavels Dimitrijevs, Klavs Pajuste, Oksana Petrichenko, Ludmila Jackevica, Anita Gulbe, Signe Kibilda, Krisjanis Smits, Mara Plotniece, Dace Tirzite, Karlis Pajuste, Arkadij Sobolev, Janis Liepins, Ilona Domracheva, Aiva Plotniece   +14 more
doaj   +1 more source

Dual‐Functional Polystyrene‐Based Borate Complexes: Recyclable Alkyl Radical Sources and Photodegradable Absorbents

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Dual‐functional polystyrene‐based polymers bearing 2,2′‐(pyridine‐2,6‐diyl)diphenol (PDP) moieties form photoexcitable alkyl borate complexes: (i) As recyclable radical sources, they enable Giese‐type additions with facile purification by reprecipitation and demonstrate proof‐of‐concept for polymer recovery (50% PDP regeneration).
Nami Jimba, Ryosei Ishii, Kazuki Wako, Tomoki Hirohata, Kosuke Sato, Tomohiro Kubo, Kotaro Satoh, Yuto Sumida, Hirohisa Ohmiya, Shinsuke Inagi   +9 more
wiley   +1 more source

GREEN SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF SOME MANNICH BASES OF 1, 4 DIHYDROPYRIDINE COMPOUNDS

International Journal of Biomedical Research, 2012
Some new Mannich Bases of 1, 4 Dihydropyridine derivatives were synthesised by reaction of 1, 4 Dihydropyridine derivatives formaldehyde (HCHO) and secondary amines (e.g. morpholine, 1-methyl piperazine) in 1:1 ratio under acidic condition in presence of trace HCl.
Jadhav, Pravin, Pujari, Rohini R., Chatterjee, N. R.   +2 more
openaire   +3 more sources

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source