Results 81 to 90 of about 85,474,312 (231)

Comparative assessment of the analgetic activityof new partially hydrogenated pyridines, α-cyanothioacetamidederivatives, in experiments of orofacial trigeminal pain and hot plate test

Research Results in Pharmacology
Introduction: Experimental studies were carried out to determine the antinociceptive activity of new partially hydrogenated pyridines, α-cyanothioacetamide derivatives, in experiments of orofacial trigeminal pain and hot plate test, implemented on white ...
Anastasiia A. Bocheva, Elena Yu. Bibik, Sergey G. Krivokolysko   +2 more
doaj   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Antimicrobial Activity of Some Derivatives of 1,4-Dihydropyridines [PDF]

, 2013
Hantzsch reported the synthesis of functionalized 1,4-dihydropyridines via three-component condensation of an aromatic aldehyde, ketoester, and ammonium hydroxide.
Prabha Mehta, Prabha Verma
core   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions

Molecules, 2006
The catalytic ability of ZrO2/SO42- to promote solventless three-componentcondensation reactions of a diversity of aromatic aldehydes, urea or thoiurea and ethylacetoacetate was studied.
Guillermo Negrón-Silva, Eduardo González-Zamora, Victor H. Lara-Corona, Leticia Lomas-Romero, Deyanira Angeles-Beltrán   +4 more
doaj   +1 more source

Synthesis and Reactivity of Imide-Derived Bisvinyl Phosphates. Reactivity of 2,6-Disubstituted 1,4-Dihydropyridines

, 2016
Symmetrical and unsymmetrical 2,6-disubstituted dihydropyridines were prepared in high yields under mild conditions using the Suzuki and Stille Pd-catalyzed coupling reactions of imide-derived bisvinyl phosphates with a range of aryl, heteroaryl, and ...
Isabelle Gillaizeau (1991881), Deborah Mousset (2532781), Pascal Bouyssou (2117956), Andréa Sabatié, (2532778), Gérard Coudert (2487463)   +4 more
core   +3 more sources

Design‐Assisted Chemometric UV Spectrophotometric Determination of Candesartan Cilexetil, Chlorthalidone and Amlodipine Using Principal Component Regression, Partial Least Squares and Genetic Algorithm‐Partial Least Squares Models

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT This study presents a sustainable chemometric‐assisted UV spectrophotometric strategy for the simultaneous determination of candesartan cilexetil (CAN), chlorthalidone (CTL) and amlodipine (AML) in laboratory‐prepared mixtures and commercial pharmaceutical formulations.
Khanda F. M. Amin, Samar H. Elagamy, Reem H. Obaydo, Hayam M. Lotfy   +3 more
wiley   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

Cyclization and n‑Heptane;Iodosuccinimide-Induced Electrophilic Iodocyclization of 3‑Aza-1,5-enynes To Synthesize 1,2-Dihydropyridines and 3‑Iodo-1,2-dihydropyridines

, 2013
Cyclization and n‑Heptane;Iodosuccinimide-Induced Electrophilic Iodocyclization of 3‑Aza-1,5-enynes To Synthesize 1,2-Dihydropyridines and 3‑Iodo-1,2 ...
吴凡, 王东平, 万伯顺, 李新成, 信晓义   +4 more
core  

A Green Lindqvist-Type POM/TEMPO/H₂O₂ Ternary Catalytic System for the Selective Oxidation of Hantzsch 1,4-Dihydropyridines (1,4-DHPs) to Pyridines

Molecules
Pyridine derivatives are prepared via the dehydrogenative aromatization of 1,4-dihydropyridines (1,4-DHPs). Among these methods, stoichiometric catalysis with high waste and electrochemical oxidation with less productivity are limited in their use ...
Qiang Zeng, Xiaoxiao Yan, Shaohong Hou, Yutong Zhang, Jiuzhong Huang, Gaorong Wu, Dan Miao, Feng Jiang, Weiming Chen   +8 more
doaj   +1 more source