Molecular docking studies of 1, 3, 4 oxadiazoles Derivatives as anti-convulsive agents [PDF]
World Journal of Advanced Research and Reviews, 2020 Molecular docking is a computational technique that places a small molecule (ligand) in the binding site of its macromolecular target (receptor) and estimates its binding affinity. The present study attempted the high throughput in-silico screening of 65 compounds docked with the GABAA receptor (PDB ID: 4COF) using Molegro virtual docker (6.0).
Sachin Jangra +2 more
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Synthesis of Some 1, 3, 4- Oxadizole Derivatives from Naproxen and Acetyl Chloride [PDF]
مجلة التربية والعلم, 2013 A seriers of 1, 3, 4-oxadiazol-2-thion were synthesized by the reaction of naproxen (or acetyl) amino acid hydrazides (glycine, valine, leucine, isoleucine and tyrosine) with carbon disulphide in alkaline medium.
Alya A. Dawood
doaj +1 more source
Synthesis and Study of Some 4-Chlorophenoxy Methyl Substituted amido1,3,4-Oxadiazoles, 1,3,4-Thiadiazoles and 1,2,4-Triazoles from 4-Chloro phenoxy acetic acid [PDF]
مجلة التربية والعلم, 2013 : In this paper the synthesis of some substituted 1,3,4-oxadiazole, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. 4-Chlorophenol was treated with chloroacetic acid to give 4-chlorophenoxy acetic acid (C1) which was reacted with thionyl chloride ...
Mudhar A. Othman, Khalid M. Daoud
doaj +1 more source
Expeditious synthesis of 1,3,4-oxadiazole derivatives via sydnones [PDF]
Journal of the Serbian Chemical Society, 2008 The clean cyclization of chalcones (1a–c/2a–c) with hydrazine hydrate under microwave irradiation afforded pyrazolines derivatised with sydnone (3d–i/4d–i), which underwent 1,3-dipolar cyclo-addition with acetic anhydride to form pyrazolines appended ...
D. G. BHADREGOWDA +2 more
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Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) [PDF]
, 2019 This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A. +6 more
core +1 more source
Synthesis of Novel 3-Acetyl N-methyl-2- Quinolone Derivatives with Expected Antimicrobial Activity
Al-Mustansiriyah Journal of Science, 2018 A series of new 3-Acetyl N-Methyl-2-quinolones oxadiazoles derivatives were synthesized by reaction of 3-acetyl-4-hydroxy-1-methylquinolin-2(1H)-one 3 with ethylbromoacetate to produce compounds 4.
Ghazwan Ali Salman
doaj +1 more source
Synthesis Of 2-Benzamidomethyl-5-Substituted Amino-1,3,4-Thiadiazoles-2,5-Disubstituted 1,3,4-Oxadiazole and 4,5-Disubstituted 1,2,4-Triazole-3-Thiol [PDF]
مجلة التربية والعلم, 2012 In this paper the synthesis of some substituted 1,3,4-oxadiazoles , 1,3,4-thiadiazoles and 1,2,4-triazoles starting from amino acid and benzoyl chloride is reported.
K. M. Daoud, A. N. Ali, A. A. Ahmed
doaj +1 more source
Фармацевтичний журнал, 2019 1,3,4-Thiadiazole and oxadiazole hetetocycles are well-known pharmacophore scaffolds, which possess wide possibility for chemical modification and identified diverse pharmacological potential.
M. I. Lelyukh
doaj +1 more source
A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids [PDF]
, 2010 Synthesis of novel orthogonally protected 1,3,4-thiadiazole and 1,3,4-oxadiazole tethered dipeptide mimetics is described. Both the heterocycles are prepared via a set of diacylhydrazines derived from amino acids.
Lamani, R.S. +3 more
core +1 more source
Molecules, 2022 Dipeptidyl peptidase-IV (DPP-IV) inhibitors, often known as gliptins, have been used to treat type 2 diabetes mellitus (T2DM). They may be combined with other medications as an additional treatment or used alone as a monotherapy.
Badrud Duza Mohammad +8 more
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