Unravelling the genome-wide contributions of specific 2-alkyl-4-quinolones and PqsE to quorum sensing in Pseudomonas aeruginosa [PDF]
PLoS Pathog, 2016 The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in vitro and in animal models of infection and is considered an ideal target for the development of anti-virulence agents.
A Bergh +64 more
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Bacterial Alkyl-4-quinolones: Discovery, Structural Diversity and Biological Properties [PDF]
Molecules, 2020 The alkyl-4-quinolones (AQs) are a class of metabolites produced primarily by members of the Pseudomonas and Burkholderia genera, consisting of a 4-quinolone core substituted by a range of pendant groups, most commonly at the C-2 position. The history of
Muhammad Saalim +2 more
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1-Phenyl-2-trifluoromethyl-4-quinolone [PDF]
Acta Crystallographica Section E Structure Reports Online, 2007 In the title mol-ecule, C(16)H(10)F(3)NO, the N-bound phenyl ring is oriented nearly orthogonal to the quinolinyl ring in order to avoid steric clashes with the trifluoro-methyl substituent [dihedral angle 89.7 (1)°].
Sadr, Moayad Hossaini +3 more
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Regiocontrolled Nitration of 4-Quinolones at Ambient Conditions [PDF]
Synthetic Communications, 2015 Regiocontrolled nitration of 4-quinolone, the highly privileged scaffold, has been developed at ambient conditions. The nitro group can selectively be introduced at diverse positions simply by tuning the reactivity of the moiety. Discrimination is being achieved through the selective functionalization of the free N-H group.
Sonali Sarkar +3 more
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4-Quinolones: Smart Phones of the Microbial World [PDF]
Chemical Reviews, 2010 The cellular telephone has revolutionized the way in which humans communicate. Since its invention, this device has evolved into the multifunctional “smart phone”. The smart phone provides us with not only a means of communication but also a useful toolkit for managing our daily lives.
Marvin Whiteley, Holly K. Huse
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A Mild and Efficient Synthesis of 4-Quinolones and Quinolone Heterocycles [PDF]
The Journal of Organic Chemistry, 2007 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
D. L. Hughes +4 more
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Hypervalent Iodine(III)-Promoted C3–H Regioselective Halogenation of 4‑Quinolones under Mild Conditions [PDF]
ACS Omega, 2021 Fang Yang +4 more
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Synthesis of 4-Quinolone Derivatives. [PDF]
Acta Chemica Scandinavica, 1995 Wim Dehaen +10 more
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Synthesis and Antibacterial Evaluation of a New Series of <em>N</em>-Alkyl-2-alkynyl/(<em>E</em>)-alkenyl-4-(1<em>H</em>)-quinolones [PDF]
Molecules, 2012 To gain further insight into the structural requirements of the aliphatic group at position 2 for their antimycobacterial activity, some <em>N</em>-alkyl-4-(1<em>H</em>)-quinolones bearing position 2 alkynyls with various chain ...
Abraham Wube +8 more
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Potentials of N-(2, 4-dinitro-1-naphthyl)-p-toluenesulphonamide and 2, 4-dinitro-1-naphthol as novel charge transfer acceptors in pharmaceutical analysis of some quinolones and cephalosporins [PDF]
Future Journal of Pharmaceutical Sciences, 2022 Background Quinolones and cephalosporins are antibiotic agents with activity against Gram-positive and Gram-negative bacteria. They contain chromophores and amine groups which are electron-rich centres capable of donating electrons to electron-deficient ...
O. E. Umoh, O. A. Adegoke, D. E. Effiong
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