Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study [PDF]
, 2016 Background Pulmonary P. aeruginosa infection is associated with poor outcomes in cystic fibrosis (CF) and early diagnosis is challenging, particularly in those who are unable to expectorate sputum. Specific P.
A. Clayton +17 more
core +2 more sources
Waltherione C and cleomiscosin from Melochia umbellata var. Degrabrata K. (Malvaceae), biosynthetic and chemotaxonomic significance [PDF]
, 2014 Waltherione C, a 4-quinolinone secondary metabolite, and cleomiscosin have been isolated from Melochia umbellata (Malvaceae).A biosynthetic scheme incorporating the unique 4-pyridones and 4-quinolones isolated from Melochia and Waltheria spp.
Noor, Alfian, Soekamto, Nunuk H.
core +1 more source
Aminoquinolones and Their Benzoquinone Dimer Hybrids as Modulators of Prion Protein Conversion
Molecules, 2022 Prion Diseases or Transmissible Spongiform Encephalopathies are neurodegenerative conditions associated with a long incubation period and progressive clinical evolution, leading to death.
Amanda Rodrigues Pinto Costa +8 more
doaj +1 more source
Synthesis of New Fused Heterocyclic 2-Quinolones and 3-Alkanonyl-4-Hydroxy-2-Quinolones
Molecules, 2019 Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c′]difuro[2,3-c:4,5-c′]-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl- butane-1,4-diones and 4-(benzo-[d]oxazol-2-yl)-3-hydroxy-1H ...
Ashraf A. Aly +7 more
doaj +1 more source
Antibiotics, 2021 (1) Background: It is unclear what underpins the large global variations in the prevalence of fluoroquinolone resistance in Gram-negative bacteria. We tested the hypothesis that different intensities in the use of quinolones for food-animals play a role.
Chris Kenyon
doaj +1 more source
Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence [PDF]
, 2017 Efflux pumps of the resistance-nodulation-cell-division (RND) family increase antibiotic resistance in many bacterial pathogens, representing candidate targets for the development of antibiotic adjuvants.
Baldelli, Valerio +8 more
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ChemInform Abstract: 4‐Quinolone Fused Heterocyclic Ring Systems by Intramolecular Reactions of 4‐Quinolone‐2‐carboxamides. [PDF]
ChemInform, 2014 Abstract A versatile synthetic route to new 4-quinolone-based polycyclic systems is described. TFA-catalyzed intramolecular reaction of N-unsubstituted quinolone-2-carboxylic acid amides gives structurally diverse compounds, depending on the length of the chain.
R. Cincinelli +3 more
openaire +3 more sources
The bactericidal activity of moxifloxacin in patients with pulmonary tuberculosis [PDF]
, 2003 Patients in whom acid-fast bacilli smear-positive pulmonary tuberculosis was newly diagnosed were randomized to receive 400 mg moxifloxacin, 300 mg isonaizid, or 600 mg rifampin daily for 5 days. Sixteen-hour overnight sputa collections were made for the
Bongard, E +7 more
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Metal Complexes of Quinolone Antibiotics and Their Applications: An Update
Molecules, 2013 Quinolones are synthetic broad-spectrum antibiotics with good oral absorption and excellent bioavailability. Due to the chemical functions found on their nucleus (a carboxylic acid function at the 3-position, and in most cases a basic piperazinyl ring ...
Valentina Uivarosi
doaj +1 more source
Communications Chemistry, 2023 The human pathogen Pseudomonas aeruginosa produces various 4(1H)-quinolones with diverse functions. Among these, 2-nonyl-4(1H)-quinolone (NQ) and its N-oxide (NQNO) belong to the main metabolites.
Viktoriia Savchenko +4 more
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