Results 21 to 30 of about 31,395 (235)
Synthesis of New Fused Heterocyclic 2-Quinolones and 3-Alkanonyl-4-Hydroxy-2-Quinolones
Molecules, 2019 Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c′]difuro[2,3-c:4,5-c′]-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl- butane-1,4-diones and 4-(benzo-[d]oxazol-2-yl)-3-hydroxy-1H ...
Ashraf A. Aly +7 more
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Antibiotics, 2021 (1) Background: It is unclear what underpins the large global variations in the prevalence of fluoroquinolone resistance in Gram-negative bacteria. We tested the hypothesis that different intensities in the use of quinolones for food-animals play a role.
Chris Kenyon
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ChemInform Abstract: 4‐Quinolone Fused Heterocyclic Ring Systems by Intramolecular Reactions of 4‐Quinolone‐2‐carboxamides. [PDF]
ChemInform, 2014 Abstract A versatile synthetic route to new 4-quinolone-based polycyclic systems is described. TFA-catalyzed intramolecular reaction of N-unsubstituted quinolone-2-carboxylic acid amides gives structurally diverse compounds, depending on the length of the chain.
R. Cincinelli +3 more
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4-Quinolones: smart phones of the microbial world. [PDF]
Chem Rev, 2011 The cellular telephone has revolutionized the way in which humans communicate. Since its invention, this device has evolved into the multifunctional “smart phone”. The smart phone provides us with not only a means of communication but also a useful toolkit for managing our daily lives.
Huse H, Whiteley M.
europepmc +5 more sources
Metal Complexes of Quinolone Antibiotics and Their Applications: An Update
Molecules, 2013 Quinolones are synthetic broad-spectrum antibiotics with good oral absorption and excellent bioavailability. Due to the chemical functions found on their nucleus (a carboxylic acid function at the 3-position, and in most cases a basic piperazinyl ring ...
Valentina Uivarosi
doaj +1 more source
Communications Chemistry, 2023 The human pathogen Pseudomonas aeruginosa produces various 4(1H)-quinolones with diverse functions. Among these, 2-nonyl-4(1H)-quinolone (NQ) and its N-oxide (NQNO) belong to the main metabolites.
Viktoriia Savchenko +4 more
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Elimination of plasmids by new 4-quinolones
Antimicrobial Agents and Chemotherapy, 1985 Nalidixic acid and six of the new 4-quinolones eliminated F'lac and various native R plasmids from Escherichia coli at one half or one quarter the MIC. Four of eight plasmids tested were cured by all derivatives, with frequencies from 10 to 98%. Quinolones did not eliminate all plasmids that were cured by novobiocin, and vice versa.
J Weisser, B Wiedemann
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DNA breakdown by the 4-quinolones and its significance [PDF]
Journal of Medical Microbiology, 1990 DNA breakdown occurred in Escherichia coli KL16 exposed to nalidixic acid, ciprofloxacin or norfloxacin. However DNA breakdown does not seem to be the cause of the lethality of the 4-quinolones because it still occurred under conditions which abolished the lethality of nalidixic acid.
C. S. Lewin, J. T. Smith
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Photosensitizer Repositioning Affords an Enantiocomplementary Enzyme for [2 + 2]‐Cycloadditions
Angewandte Chemie, EarlyView.In this study, we capitalize on the versatility offered by genetic code expansion to develop a proficient photoenzyme for [2 + 2]‐cycloadditions that is enantiocomplementary to our recently developed photoenzyme EnT1.3. By repositioning the genetically programmed benzophenone photosensitizer and subsequent directed evolution, we have developed an ...
Chuanjie Sun +9 more
wiley +2 more sources
Beilstein Journal of Organic Chemistry, 2019 Selectively methylated analogues of naturally occurring 2-heptyl-4(1H)-quinolones, which are alkaloids common within the Rutaceae family and moreover are associated with quorum sensing and virulence of the human pathogen Pseudomonas aeruginosa, have been
Sven Thierbach +3 more
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