Results 1 to 10 of about 11,548,212 (369)

Novel 1, 2, 4-Triazoles as Antifungal Agents. [PDF]

Biomed Res Int, 2022
The development of innovative antifungal agents is essential. Some fungicidal agents are no longer effective due to resistance development, various side effects, and high toxicity. Therefore, the synthesis and development of some new antifungal agents are necessary. 1,2,4‐Triazole is one of the most essential pharmacophore systems between five‐membered
Kazeminejad Z, Marzi M, Shiroudi A, Kouhpayeh SA, Farjam M, Zarenezhad E.   +5 more
europepmc   +4 more sources

Regioselectivity in the Thermal Rearrangement of Unsymmetrical 4-Methyl-4H-1,2,4-triazoles to 1-Methyl-1H-1,2,4-triazoles [PDF]

Molecules, 2001
The rearrangement of 4-methyl-3,5-diaryl-4H-1,2,4-triazoles to the corresponding 1-methyl-3,5-diaryl-1H-1,2,4-triazoles showed regioselectivity comparable to that observed for the alkylation of 3,5-diaryl-1H-1,2,4-triazoles.
Per H.J. Carlsen, Odd R. Gautun
doaj   +2 more sources

Synthesis, Antibacterial and Antifungal Activity of 4-Substituted-5-Aryl-1,2,4-Triazoles

Molecules, 2001
A few 4-allyl/amino-5-aryl-1,2,4-triazoles were synthesized and tested for antibacterial and antifungal effects against Escherichia coli, Bacillus subtilis, Salmonella enteritidis, Staphylococcus aureus, Aspergillus niger and Candida albicans.
Aleksandra Buzarovska, Dora Gabor Molnar, Vlado Kakurinov, Vesna Dimova, Katica Colanceska-Ragenovic   +4 more
doaj   +2 more sources

Azide–alkyne cycloaddition (click) reaction in biomass-derived solvent CyreneTM under one-pot conditions [PDF]

Beilstein Journal of Organic Chemistry
It was demonstrated that CyreneTM, as a biomass-originated polar aprotic solvent, could be utilized as an alternative reaction medium for one-pot copper(I)-catalyzed azide–alkyne cycloaddition (click or CuAAC) reactions, for the synthesis of various 1,2 ...
Zoltán Medgyesi, László T. Mika
doaj   +2 more sources

Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity [PDF]

Journal of Chemistry, 2007
Cyclisation of [4‐(4‐oxo‐2‐phenyl‐4H‐quinazolin‐3‐yl)‐phenoxy]‐acetic acid‐N′‐(substituted phenyl)‐thiosemicarbazides with sodium metal in 99.0 % ethanol gave 3‐[4‐(4‐substituted phenyl‐5‐thioxo‐4,5‐dihydro‐1H‐1,2,4 triazol‐3‐ylmethoxy)‐ phenyl]‐2‐phenyl‐3H‐quinazolin‐4‐one .
Freddy H. Havaldar, Abhay R. Patil
openalex   +4 more sources

Novel Syntheses of Some 1, 2, 4‐Triazoles as Potent Bacteriocidal Agents [PDF]

Journal of Chemistry, 2009
A facile syntheses of 4‐aryl‐5‐(isomeric pyridoyl)‐3H‐1, 2, 4‐triazoles as potent bacteriocidal agents are described. The newly synthesized compounds were characterized by spectral and elemental analyses. Some compounds were screened for their antibacterial activity against S. aureus, E. coli, B. subtilis and P.aeruginosa. All compounds carrying 1, 2,
Ram Janam Singh, Dharmendra Kumar Singh
openaire   +3 more sources

Comparative Study of Goitrogenic Actions of 3-Substituted 1, 2, 4-Triazoles in Rats.

Journal of Veterinary Medical Science, 1994
Antithyroid actions of 3-amino-1, 2, 4-triazole (ATZ), 3-mercapto-1, 2, 4-triazole (MTZ) and 3-nitro-1, 2, 4-triazole (NTZ), which are substituents on the 3-position of 1, 2, 4-triazole (TZ), and those of the parental compound, were compared in rats. After administration of either ATZ, MTZ, or NTZ, the thyroids of rats were enlarged with decreasing of ...
Masaya Takaoka, Sunao Manabe, Takashi Yamoto, Masaaki Teranishi, N. Matsunuma, Hiroshi Masuda, Naoaki GOTO   +6 more
openalex   +4 more sources

Access to Substituted Tricyclic Heteroarenes by an Oxidative Cyclization Reaction and Their Antifungal Performance [PDF]

Pharmaceuticals
Background/Objectives: Fungal pathogens are increasingly developing concerning resistance against the currently available antifungal drugs, which creates a constant demand for new antifungal agents.
Rehema Nakiwala, Noopur Dasgupta, Rebecca Wilson, Erika I. Lutter, Jeanne L. Bolliger   +4 more
doaj   +2 more sources

Torsade de Pointes/QT Prolongation Associated with Antifungal Triazoles: A Pharmacovigilance Study Based on the U.S. FDA Adverse Event Reporting System（FAERS）

Journal of Pharmacy & Pharmaceutical Sciences, 2022
Purpose: Torsade de pointes (TdP)/QT prolongation is a fatal adverse event (AE) when using antifungal triazoles. We aimed to compare the AE signals of TdP/QT prolongation and onset time among different drugs of this kind comprehensively.
Zicheng Yu, Xiaolan Liao
doaj   +1 more source

Design and antiproliferative and antioxidant activities of furan-based thiosemicarbazides and 1,2,4-triazoles: their structure-activity relationship and SwissADME predictions

Medicinal Chemistry Research, 2021
Due to the limited number of drugs in current clinical use, the diverse biological applications of furan have encouraged the preparation of a wide variety of thiosemicarbazide and triazole derivatives for the purpose of developing new drug agents.
Y. Sıcak
semanticscholar   +1 more source