Results 1 to 10 of about 18,771 (284)
Novel 1, 2, 4-Triazoles as Antifungal Agents. [PDF]
Biomed Res Int, 2022 The development of innovative antifungal agents is essential. Some fungicidal agents are no longer effective due to resistance development, various side effects, and high toxicity. Therefore, the synthesis and development of some new antifungal agents are necessary. 1,2,4‐Triazole is one of the most essential pharmacophore systems between five‐membered
Kazeminejad Z +5 more
europepmc +3 more sources
Regioselectivity in the Thermal Rearrangement of Unsymmetrical 4-Methyl-4H-1,2,4-triazoles to 1-Methyl-1H-1,2,4-triazoles [PDF]
Molecules, 2001 The rearrangement of 4-methyl-3,5-diaryl-4H-1,2,4-triazoles to the corresponding 1-methyl-3,5-diaryl-1H-1,2,4-triazoles showed regioselectivity comparable to that observed for the alkylation of 3,5-diaryl-1H-1,2,4-triazoles.
Per H.J. Carlsen, Odd R. Gautun
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Access to Substituted Tricyclic Heteroarenes by an Oxidative Cyclization Reaction and Their Antifungal Performance [PDF]
PharmaceuticalsBackground/Objectives: Fungal pathogens are increasingly developing concerning resistance against the currently available antifungal drugs, which creates a constant demand for new antifungal agents.
Rehema Nakiwala +4 more
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Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity [PDF]
Journal of Chemistry, 2007 Cyclisation of [4‐(4‐oxo‐2‐phenyl‐4H‐quinazolin‐3‐yl)‐phenoxy]‐acetic acid‐N′‐(substituted phenyl)‐thiosemicarbazides with sodium metal in 99.0 % ethanol gave 3‐[4‐(4‐substituted phenyl‐5‐thioxo‐4,5‐dihydro‐1H‐1,2,4 triazol‐3‐ylmethoxy)‐ phenyl]‐2‐phenyl‐3H‐quinazolin‐4‐one .
Freddy H. Havaldar, Abhay R. Patil
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Comparative Study of Goitrogenic Actions of 3-Substituted 1, 2, 4-Triazoles in Rats.
Journal of Veterinary Medical Science, 1994 Antithyroid actions of 3-amino-1, 2, 4-triazole (ATZ), 3-mercapto-1, 2, 4-triazole (MTZ) and 3-nitro-1, 2, 4-triazole (NTZ), which are substituents on the 3-position of 1, 2, 4-triazole (TZ), and those of the parental compound, were compared in rats. After administration of either ATZ, MTZ, or NTZ, the thyroids of rats were enlarged with decreasing of ...
Masaya Takaoka +6 more
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Novel Syntheses of Some 1, 2, 4-Triazoles as Potent Bacteriocidal Agents [PDF]
E-Journal of Chemistry, 2010 A facile syntheses of 4-aryl-5-(isomeric pyridoyl)-3H-1, 2, 4-triazoles as potent bacteriocidal agents are described. The newly synthesized compounds were characterized by spectral and elemental analyses.
Ram Janam Singh, Dharmendra Kumar Singh
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Syntheses, Characterization and Biological Activity of Some 1, 2, 4-Triazole Derivatives [PDF]
E-Journal of Chemistry, 2009 Syntheses of a series of 3-alkyl-4- amino-5- cyanomethyl-4H-1, 2, 4-triazoles with active methylene groups are described. The newly synthesized compounds were characterized by spectral and elemental analyses.
R. J. Singh, D. K. Singh
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Journal of Pharmacy & Pharmaceutical Sciences, 2022 Purpose: Torsade de pointes (TdP)/QT prolongation is a fatal adverse event (AE) when using antifungal triazoles. We aimed to compare the AE signals of TdP/QT prolongation and onset time among different drugs of this kind comprehensively.
Zicheng Yu, Xiaolan Liao
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Журнал органічної та фармацевтичної хімії, 2022 Aim. To analyze and summarize the synthetic potential of 1,2,3-triazole-4(5)-amines as efficient building blocks in the synthesis of triazolo-annulated pyridine, azine and azepine systems. Results and discussion.
Natalia O. Syrota +3 more
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Molecules, 2021 Cu-catalyzed 1,3-dipolar cycloaddition of methyl 2-azidoacetate to iodobuta-1,3-diynes and subsequent Suzuki-Miyaura cross-coupling were used to synthesize new triazoles derivatives: 5-aryl-4-arylethynyl-1H-1,2,3-triazoles. Investigation of their optical
Mariia M. Efremova +4 more
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