Results 51 to 60 of about 18,771 (284)

Enantioconvergent Deacylative Functionalization toward α‐Quaternary Nitriles

Angewandte Chemie, EarlyView.
An enantioconvergent quaternary‐to‐quaternary synthesis of α‐chiral nitriles has been enabled. By replacing the acyl group with a variety of allyl, propargyl, and benzyl motifs, the functional group swap can convert easily available β‐ketonitriles to assorted quaternary stereocenters en route to bioactive molecules of broad interests.
Minghao Zhang, Zhongxing Huang
wiley   +2 more sources

Harnessing Synergistic Cooperation of Neighboring Active Motifs in Heterogeneous Catalysts for Enhanced Catalytic Performance

Advanced Materials, EarlyView.
This review examines the critical role of neighboring active motifs in heterogeneous catalysts, emphasizing how their synergistic cooperativity can be rationally designed to modulate catalytic properties. The discussion centers on the modulation of electronic and geometric structures, categorizing the catalytic systems into metal‐acid (Brønsted/Lewis ...
Peng Yuan, Ching Kit Tommy Wun, Tsz Woon Benedict Lo   +2 more
wiley   +1 more source

Near‐Zero Thermal Expansion in Coordination Polymer Cd(1,2,4‐Triazole)2(H2PO4)2

Angewandte Chemie, EarlyView.
The structural dynamics and the chemical bonding origin of a volumetric near‐zero thermal expansion in a coordination polymer across 25 K to 400 K is studied using multi‐temperature X‐ray crystallography and X‐ray electron density analysis. The lattice expansion in the a and c directions is counteracted by contraction along b axis, caused by concerted ...
Sounak Sarkar, Bo Brummerstedt Iversen
wiley   +2 more sources

5-Furan-2yl[1,3,4]oxadiazole-2-thiol, 5-Furan-2yl-4H [1,2,4] triazole-3-thiol and Their Thiol-Thione Tautomerism

Molecules, 2005
5-Furan-2-yl[1,3,4]oxadiazole-2-thiol (Ia) and 5-furan-2-yl-4H-[1,2,4]-triazole-3-thiol (Ib) were synthesized from furan-2-carboxylic acid hydrazide. Mannich basesand methyl derivatives were then prepared.
A. Cansız, A. Çetin, M. Koparır   +2 more
doaj   +1 more source

Thermally Activated Delayed Fluorescence and Beyond. Photophysics and Material Design Strategies.

Advanced Photonics Research, EarlyView.
Photophysical properties of TADF molecules are determined by characteristic parameters that are discussed in detail(. Moreover, using femtosecond time‐resolved spectroscopy, quantum mechanical considerations, and state‐of‐art calculations, deeper understanding allows us to design breakthrough Cu(I) and organic TADF‐ OLED materials. For the latter ones,
Hartmut Yersin, Uwe Monkowius
wiley   +1 more source

TBADT‐Mediated C‐C Bond Formation Exploiting Aryl Aldehydes in a Photochemical Flow Reactor

ChemCatChem, Volume 15, Issue 2, January 20, 2023., 2023
Scaled Photochemical Reactions: A continuous flow approach for the photochemical synthesis of β‐ketonitriles and related species is presented. This approach tolerates (hetero)aromatic substrates and uses readily available TBADT as an effective HAT catalyst reaching throughputs of up to 41 mmol/h.
Adam Cruise, Marcus Baumann
wiley   +1 more source

Low‐Symmetry Face‐Capped Fe(II) Tetrahedra Through Anisotropic Ligand Extension

Angewandte Chemie, EarlyView.
A strategy for the formation of low‐symmetry face‐capped Fe(II) tetrahedra using anisotropic ligand extension is reported. The degree of distortion in the resulting tetrahedra correlates to the stability of the assemblies and the oxidation potentials of their metal ions. Abstract Low‐symmetry cages are attractive metallo‐supramolecular targets, as they
Jacob A. Gome, Zack T. Avery, Nina R. Lawson, Oliver G. Stansfield, Jack D. Evans, Michael G. Gardiner, Timothy U. Connell, Dan Preston   +7 more
wiley   +2 more sources

Engineered Hydrogels for Organoid Models of Human Nonalcoholic Fatty Liver Disease

Advanced Science, EarlyView.
Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation and extracellular matrix stiffening. An in vitro NAFLD model is developed using engineered hydrogels (G′ ≈ 1–6 kPa) and iPSC‐derived hepatic organoids. It is demonstrated that higher stiffness can increase lipid droplet accumulation, fibrosis, and metabolic dysregulation ...
Yueming Liu, Aidan E. Gilchrist, Patrik K. Johansson, Yuan Guan, Jaydon D. Deras, Yu‐Chung Liu, Sofia Ceva, Michelle S. Huang, Renato S. Navarro, Annika Enejder, Gary Peltz, Sarah C. Heilshorn   +11 more
wiley   +1 more source

PPh3/Isocyanide and N2/Isocyanide Exchange: Pathways to Isolable Alkali Metal Keteniminyl Anions

Angewandte Chemie, EarlyView.
The synthesis of isolable keteniminyl anions through substitution of the phosphine ligand in metalated ylides or the N₂ ligand in diazomethanides with isocyanides is reported. The anions feature a bent geometry, with the angle decreasing with increasing donor ability of the nitrogen substituent, and exhibit broad applicability in the formation of ...
Sunita Mondal, Yihao Zhang, Prakash Duari, Kai‐Stephan Feichtner, Arpan Das, Lili Zhao, Gernot Frenking, Viktoria H. Gessner   +7 more
wiley   +2 more sources

Functionalized Biomimetic Nanoparticles Targeting the IL‐10/IL‐10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis

Advanced Science, EarlyView.
The MOF material UIO‐66‐NH2 is functionalized with DBCO groups on its surface, encapsulating NO‐prednisolone and conjugating it with azide‐modified IL‐10. Finally, the complex is extruded with MM to form biomimetic functional nanoparticles. Upon intra‐articular injection, MI@UN, enveloped by the MM, specifically targets synovial macrophages, is ...
Wenwei Li, Yang Liu, Ming Wei, Zhichao Yang, Zhaoyu Li, Zezhong Guo, Liang Yan, Yang Lu, Hao Tang, Bofeng Li, Wei Huang   +10 more
wiley   +1 more source