Results 11 to 20 of about 13,836,694 (159)

Effect of 5-aminolevulinic Acid on Mitochondrial Activity

Frontiers in Bioscience-Scholar, 2023
Background: Mitochondrial dysfunction is considered an important mechanism in the pathogenesis of various diseases. Therefore, mitochondria are currently being considered as subjects for targeted therapies, particularly, phototherapy using 5 ...
Yuliya V. Markina, Alexander M. Markin, Tatiana V. Kirichenko, Taisiya V. Tolstik, Vadim R. Cherednichenko, Diana G. Kiseleva, Alexander N. Orekhov   +6 more
doaj   +2 more sources

Photodynamic therapy in the treatment of extramammary paget’s disease

Biomedical Photonics, 2022
Extramammary Paget’s disease (EMPD) is a rare tumor that predominantly affects the skin containing apocrine glands. Due to insufficient data on the effectiveness of different methods, there is no single therapeutic approach to the treatment of patients ...
E. V. Filonenko, V. Ivanova-Radkevich
doaj   +1 more source

Transurethral resection and surveillance of bladder cancer supported by 5-aminolevulinic acid-induced fluorescence endoscopy [PDF]

, 1999
Purpose: We determined whether neoplastic disease, which was missed under white light can be found during transurethral resection of bladder cancer by 5-aminolevulinic acid-induced porphyrin fluorescence.
Kriegmair, Martin, Knüchel, Ruth, Stepp, Helmut, Zaak, Dirk, Stepp, Herbert, Hofstetter, Alfons, Baumgartner, Reinhold, Dirk Zaak, Helmut Stepp, Reinhold Baumgartner, Martin Kriegmair, Alfons Hofstetter, Herbert Stepp, Ruth Knuechel   +13 more
core   +1 more source

Kinetics of 5-aminolevulinic acid-induced fluorescence in organ cultures of bronchial epithelium and tumor [PDF]

, 2002
Background: 5-Aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PPIX) fluorescence improves the differentiation of tumor and normal tissue in the bladder, skin and brain. Objective: The kinetics of 5-ALA-induced protoporphyrin IX (PPIX) fluorescence
Bergner, Albrecht, Maier, Irmgard, Gamarra, Fernando, Al-Batran, Salah, Baumgartner, Reinhold, Wagner, Simon, Castro, Mirna, Hautmann, Hubert, Huber, Rudolf M.   +8 more
core   +1 more source

Photodynamic therapy of prostate cancer by means of 5-aminolevulinic acid-induced protoporphyrin IX - In vivo experiments on the dunning rat tumor model [PDF]

, 2004
Objective: In order to expand the use of photodynamic therapy (PDT) in the treatment of prostate carcinoma (PCA), the aim of this study was to evaluate PDT by means of 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX ( PPIX) in an in vivo tumor ...
Schneede, Peter, Lein, Michael, Bise, Karl, Zaak, Dirk, Baumgartner, Reinhold, Stocker, Susanne, Höppner, Michael, Kriegmair, Martin, Knüchel, Ruth, Hofstetter, Alfons, Frimberger, Dominic, Sroka, Ronald, Reich, Oliver   +12 more
core   +1 more source

Identification of risk factors for post-induction hypotension in patients receiving 5-aminolevulinic acid: a single-center retrospective study

JA Clinical Reports, 2020
Background 5-Aminolevulinic acid (5-ALA) is useful as a photodynamic agent, but its use commonly leads to hypotension. Although avoiding a mean arterial pressure (MAP) < 60 mmHg is important, the incidence of MAP < 60 mmHg when using 5-ALA is unclear ...
Tomoaki Yatabe, Takashi Karashima, Motohiko Kume, Yu Kawanishi, Hideo Fukuhara, Tetsuya Ueba, Keiji Inoue, Yoshiyasu Okuhara, Masataka Yokoyama   +8 more
doaj   +1 more source

Systems metabolic engineering of Escherichia coli for hyper-production of 5‑aminolevulinic acid

Biotechnology for Biofuels and Bioproducts, 2023
Background 5-Aminolevulinic acid (5-ALA) is a promising biostimulant, feed nutrient, and photodynamic drug with wide applications in modern agriculture and therapy.
Wei Pu, Jiuzhou Chen, Yingyu Zhou, Huamin Qiu, Tuo Shi, Wenjuan Zhou, Xuan Guo, Ningyun Cai, Zijian Tan, Jiao Liu, Jinhui Feng, Yu Wang, Ping Zheng, Jibin Sun   +13 more
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5-Aminolevulinic acid synthase: mechanism, mutations and medicine

, 2003
5-Aminolevulinic acid synthase (ALAS), the first enzyme of the heme biosynthesis pathway, catalyses the pyridoxal 5'-phosphate-dependent condensation between glycine and succinyl-CoA to yield 5-aminolevulinic acid (5-amino-4-oxopentanoate).
Bottomley, S.S., Roy, I., Sarwar, M., Sawyer, L., Baxter, R.L., Shoolingin-Jordan, P., Kahari, D., Shoolingin-Jordan, P.M., Alexeev, D., Al-Daihan, S., Kahari, I.D., Wang, S.F.   +11 more
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5-Aminolevulinic acid: A matter of life and caveats

Journal of Photochemistry and Photobiology, 2021
Our mini-review concerns the potential adverse pro-oxidant role of 5-aminolevulinic (ALA), the first protoporphyrin IX (PP-IX)/heme precursor widely used in commercial formulations for endogenous photodynamic therapy (PDT).
Etelvino J.H. Bechara, Luiz D. Ramos, Cassius V. Stevani   +2 more
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Fluorescence‐based discrimination of breast cancer cells by direct exposure to 5‐aminolevulinic acid

Cancer Medicine, 2019
Protoporphyrin IX‐fluorescence measurement is a powerful in situ approach for cancer detection after oral/topical administration of 5‐aminolevulinic acid.
Midori Morita, Hideo Tanaka, Yasuaki Kumamoto, Akihiro Nakamura, Yoshinori Harada, Takehiro Ogata, Koichi Sakaguchi, Tetsuya Taguchi, Tetsuro Takamatsu   +8 more
doaj   +1 more source