DNA Base Excision Repair Modulates DNA Repeat Instability and Non-B Form DNA Structures [PDF]
, 2020 The human genome is constantly attacked by endogenous and exogenous sources of DNA damage that generates DNA base lesions and strand breaks leading to genome instability, cell death, and diseases.
Laverde, Eduardo E
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Structural and functional studies of enzymes in nucleotide metabolism [PDF]
, 2011 Enzymes in nucleotide metabolism serve as the producers of the building blocks for DNA and RNA. From a medical perspective, nucleotide metabolism, and in particular salvage pathway enzymes, have attracted special interest, as nucleoside prodrugs given in
Egeblad, Louise
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The Contribution of DNA Interstrand Crosslinks to Aging [PDF]
, 2012 DNA damage is hypothesized to be a driver of aging. In support of this, DNA damage and genetic mutations, resulting from replication of that damage, both increase in the nuclear genome as organisms age.
Robinson, Andria R
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Laboratory-directed research and development: FY 1996 progress report [PDF]
, 1997 This report summarizes the FY 1996 goals and accomplishments of Laboratory-Directed Research and Development (LDRD) projects. It gives an overview of the LDRD program, summarizes work done on individual research projects, and provides an index to the ...
Prono, J., Vigil, J.
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Exploration of Ataxia Telangiectasia and Rad3-Related’s (ATR’s) Role in Cell Death Regulation: Implications in Development, Cancer, and Stroke [PDF]
, 2019 From gametogenesis until death an organism’s genome is under constant bombardment from endogenous and exogenous sources of DNA damage. To maintain genomic integrity amid this damage, cells have evolved responses which allow them to either preserve ...
Cartwright, Brian
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Synthetic bacterial communities for plant growth promotion [PDF]
, 2021 PhD ThesisIncreasing food demands have driven the adoption of new global strategies to intensify productivity without relying on heavy chemical treatments.
Verrone, Valeria
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Enantioselective separation of fluorescence tagged amino acids using chiral anion exchangers [PDF]
, 2012 Im Zuge der Masterarbeit wurde die Enantiomerentrennung von Aminosäuren (AS) unter Verwendung von auf Chinin/Chinidin-basierenden chiralen stationären Phasen untersucht.
Hellinger, Roland
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Approaches for rejuvenating the natural product discovery process from Streptomyces [PDF]
In 1940, a bacterial enzyme was identified which was capable of destroying penicillin (Abraham & Chain, 1940). This discovery actually predated both the awarding of the Nobel Peace Prize in Medicine and Physiology for its discovery and the year it became
Scobie, Darren James
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Trinucleotide Repeat Instability Modulated by DNA Repair Enzymes and Cofactors [PDF]
, 2018 Trinucleotide repeat (TNR) instability including repeat expansions and repeat deletions is the cause of more than 40 inherited incurable neurodegenerative diseases and cancer.
Ren, Yaou
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Trinucleotide Repeat Instability is Modulated by DNA Base Lesions and DNA Base Excision Repair [PDF]
, 2016 Trinucleotide repeat (TNR) expansions are the cause of over 40 human neurodegenerative diseases, and are linked to DNA damage and base excision repair (BER). We explored the role of DNA damage and BER in modulating TNR instability through analysis of DNA
Beaver, Jill M
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