Results 111 to 120 of about 345,197 (240)

A new combination of 5’- and 3’-untranslated regions increases the expression of mRNAs in vitro and in vivo

Вавиловский журнал генетики и селекции
mRNA vaccine technologies have been actively developing since the beginning of the 21st century and have received a major boost from new findings about the functioning of the immune system and the development of efficient vehicles for nucleic acid ...
D. N. Antropov, O. V. Markov, A. S. Dome, P. A. Puchkov, E. V. Shmendel, D. V. Gladkikh, V. M. Golyshev, A. M. Matveeva, M. A. Maslov, G. A. Stepanov   +9 more
doaj   +1 more source

MicroRNA‐Seq Analysis Reveals a Critical Role for miR‐222 in Bovine Intramuscular Adipogenesis via the DDIT4/mTORC1 Axis

Animal Research and One Health, EarlyView.
Schematic diagram illustrating how miR‐222 promotes bovine intramuscular adipogenesis by targeting DDIT4 to activate the mTORC1 signaling pathway. ABSTRACT Intramuscular fat (IMF) is a key determinant of beef quality, particularly with respect to tenderness, flavor, and juiciness.
Jianbing Tan, Liang Qiu, Zhenghai Zhou, Zhipeng Zhang, Nanfei Wang, Jiangang Hao, Linsen Zan, Wucai Yang   +7 more
wiley   +1 more source

Investigating 5’ untranslated regions and translational regulation across human genes

Untranslated regions (UTRs) are important mediators of post-transcriptional regulation. The length of UTRs and the composition of regulatory elements within them are known to vary substantially across genes, but the reasons remain poorly understood in ...
Tatz-Wieder, Nechama
core   +2 more sources

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

HuB serves as the central hub for connecting HuR-related mRNAs with translation machinery in inflammation

Communications Biology
The mRNAs of inflammatory factors often contain unstable AU-rich elements (AREs) within their 3’ untranslated regions (3’UTRs), and HuR is a key ARE-binding protein to recognize such elements.
Jing Zhang, Ximan Huang, Yunhan Tang, Xiyue Zhong, Jing Wang, Min Wei, Xiaoqing Han, Yueshuang Ke, Xueqing Ba   +8 more
doaj   +1 more source

Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis

Animal Research and One Health, EarlyView.
Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li, Yuchen He, Yangshuo Hu, Naominggaowa, Huaiqiang Yang, Zhu Meng, Fei Liu, Shiwen Zhang, Yi Jin, Mingxing Chu, Zhangyuan Pan   +10 more
wiley   +1 more source

Biophysical characterization of honey bee virus untranslated regions

Over the past two decades, honey bee colony losses have become a serious and widespread issue. Many factors contribute to these losses, but one major driver is viruses.
University of Lethbridge. Faculty of Arts and Science, Letain, Jenna M.   +1 more
core  

PLoS One [PDF]

A type 2 vaccine-derived poliovirus (VDPV), differing from the Sabin 2 strain at 8.6% (78/903) of VP1 nucleotide positions, was isolated from seawater collected from a seaport in S\ue3o Paulo State, Brazil.

core  

Tetraspanin‐ESCRT sorting drives miR‐29b packaging into extracellular vesicles to reverse fibrosis in intrauterine adhesions

BMEMat, EarlyView.
MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen, Jianfeng Wu, Shunhan Zhang, Siqi Huang, Yingjun Xie, Hongda Chen, Yinghong Yang, Lan Xiao, Ding Wang, Keke Wu, Xiaofang Sun   +10 more
wiley   +1 more source

Mutational Analysis ofCis-Acting Sequences in the 3′- and 5′-Untranslated Regions of RNA2 of Red Clover Necrotic Mosaic Virus

, 1999
Mutational analysis has been used to investigatecis-acting sequences in the 3′- and 5′-untranslated regions of red clover necrotic mosaic virus RNA2 required for replication in the presence of wild-type RNA1.
Turner, Roisin L., Buck, Kenneth W.
core   +1 more source