Cell identity and 5-hydroxymethylcytosine [PDF]
Epigenetics & ChromatinEpigenetic factors underlie cellular identity through the regulation of transcriptional networks that establish a cell’s phenotype and function. Cell conversions are directed by transcription factor binding at target DNA which induce changes to identity ...
Floris Honig, Adele Murrell
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Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer’s disease neuropathology [PDF]
Nature Communications5-hydroxymethylcytosine, also known as the sixth DNA base of the genome, plays an important role in brain aging and neurological disorders such as Alzheimer’s disease.
Jinying Zhao +18 more
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Elevated 5hmC levels characterize DNA of the cerebellum in Parkinson’s disease [PDF]
npj Parkinson's Disease, 2017 5-methylcytosine and the oxidation product 5-hydroxymethylcytosine are two prominent epigenetic variants of the cytosine base in nuclear DNA of mammalian brains.
Reinhard Stöger +3 more
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eLife, 2021 Although high levels of 5-hydroxymethylcytosine (5hmC) accumulate in mammalian neurons, our knowledge of its roles in terminal differentiation or as an intermediate in active DNA demethylation is incomplete.
Elitsa Stoyanova +3 more
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Tissue-specific 5-hydroxymethylcytosine landscape of the human genome
Nature Communications, 2021 Charting the landscape of 5hmC in human tissues is fundamental to understanding its regulatory functions. Here, we systematically profiled the whole-genome 5hmC landscape at single-base resolution for 19 types of human tissues and found 5hmC shows tissue-
Bo He +11 more
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5-Hydroxymethylcytosine: Far Beyond the Intermediate of DNA Demethylation. [PDF]
Int J Mol SciEpigenetics plays a pivotal role in regulating gene expression and cellular differentiation. DNA methylation, involving the addition of methyl groups to specific cytosine bases, is a well-known epigenetic modification.
Zheng K, Lyu Z, Chen J, Chen G.
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Double and single stranded detection of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore sequencing. [PDF]
Commun Biol5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are modified versions of cytosine in DNA with roles in regulating gene expression. Using whole genomic DNA from mouse cerebellum, we benchmark 5mC and 5hmC detection by Oxford Nanopore ...
Halliwell DO +4 more
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Genome‐Wide 5‐Methylcytosine and 5‐Hydroxymethylcytosine Signatures Analysis of Plasma Cell‐Free DNA in Schizophrenia [PDF]
MedCommSchizophrenia (SCZ) is a highly heritable neuropsychiatric disorder that affects ∼1% of people globally. Despite extensive research, there remains a lack of biomarkers for SCZ diagnosis and disease pathogenesis delineation.
Gang Xue +13 more
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The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases [PDF]
Frontiers in Neuroscience, 2014 DNA methylation primarily occurs within human cells as a 5-methylcytosine (5mC) modification of the cytosine bases in CpG dinucleotides. 5mC has proven to be an important epigenetic mark that is involved in the control of gene transcription for processes
Sahar eAl-Mahdawi +5 more
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A hybrid residue based sequential encoding mechanism with XGBoost improved ensemble model for identifying 5-hydroxymethylcytosine modifications. [PDF]
Sci RepRNA modifications play an important role in actively controlling recently created formation in cellular regulation mechanisms, which link them to gene expression and protein.
Uddin I +7 more
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