Results 101 to 110 of about 12,448,100 (233)

TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation

Epigenetics & Chromatin, 2022
Background Poly(ADP-ribosyl)ation (PARylation), a posttranslational modification introduced by PARP-1 and PARP-2, has first been implicated in DNA demethylation due to its role in base excision repair. Recent evidence indicates a direct influence of PARP-
Anja Tolić, Mirunalini Ravichandran, Jovana Rajić, Marija Đorđević, Miloš Đorđević, Svetlana Dinić, Nevena Grdović, Jelena Arambašić Jovanović, Mirjana Mihailović, Nataša Nestorović, Tomasz P. Jurkowski, Aleksandra S. Uskoković, Melita S. Vidaković   +12 more
doaj   +1 more source

Bi-directional and shared epigenomic signatures following proton and 56Fe irradiation. [PDF]

, 2017
The brain's response to radiation exposure is an important concern for patients undergoing cancer therapy and astronauts on long missions in deep space.
Fareh, Fatema, Impey, Soren, Jopson, Timothy, Marzulla, Tessa, Pelz, Carl, Raber, Jacob, Riparip, Lara-Kirstie, Rosi, Susanna, Stewart, Blair, Tafessu, Amanuel, Turker, Mitchell S, Zuloaga, Damian   +11 more
core   +2 more sources

The role of 5-hydroxymethylcytosine in human cancer [PDF]

Cell and Tissue Research, 2014
The patterns of DNA methylation in human cancer cells are highly abnormal and often involve the acquisition of DNA hypermethylation at hundreds or thousands of CpG islands that are usually unmethylated in normal tissues. The recent discovery of 5-hydroxymethylcytosine (5hmC) as an enzymatic oxidation product of 5-methylcytosine (5mC) has led to models ...
Gerd P, Pfeifer, Wenying, Xiong, Maria A, Hahn, Seung-Gi, Jin   +3 more
openaire   +2 more sources

Re‐conceptualizing Parkinson's disease as a lifelong neurobiological trajectory: A framework for prevention

Neuroprotection, Volume 4, Issue 1, Page 14-29, March 2026.
Three‐panel graphical abstract showing the Lifelong Neurobiological Trajectory framework for Parkinson's disease: (1) Vulnerability pathway (top, red) showing how early adversity → epigenetic dysregulation, neuroinflammation, and mitochondrial dysfunction → ↑ PD risk; (2) Lifespan timeline (middle, purple) spanning prenatal/infancy → childhood ...
Ayodeji Johnson Ajibare, Abraham Olufemi Asuku, Olabode Oluwadare Akintoye   +2 more
wiley   +1 more source

Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences [PDF]

, 2016
DNA methylation is the best known epigenetic mark. Cancer and other pathologies show an altered DNA methylome. However, delivering complete DNA methylation maps is compromised by the price and labor-intensive interpretation of single nucleotide methods ...
Arribas, Carles, Esteller, Manel, Moran, Sebastian   +2 more
core   +1 more source

Ageing Through the Looking‐Glass: The Different Flavours of Clonal Haematopoiesis

Aging Cell, Volume 25, Issue 3, March 2026.
Different forms of CH share common germline and environmental risk factors and have overlapping prevalence and disease associations, suggesting common underlying ageing processes. We explore intersections of different forms of CH, clinical implications of these, and how this enhances our understanding of the biology of ageing.
Jasmine Singh, David J. Curtis, Le Thi Phuong Thao, Erica M. Wood, Zoe K. McQuilten   +4 more
wiley   +1 more source

Hypoxia Promotes an Adrenergic to Mesenchymal Transcriptional Program Transition in Neuroblastoma

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Adrenergic (ADRN) neuroblastoma cells have a paradoxical increase in TET1 expression and 5‐hydroxymethylcytosine (5‐hmC) deposition in hypoxia. However, the effect of hypoxia on the mesenchymal (MES) lineage remains less well understood. To identify lineage specific hypoxia responses, we evaluated 5‐hmC and RNA expression in a panel of ADRN ...
Gepoliano S. Chaves, Mohansrinivas Chennakesavalu, Kelley Moore, Hannah Adams, Cara Chittenden, Emma Wilkinson, Omar Vayani, Maria E. Kaufman, Alexandre Chlenski, Chuan He, Susan L. Cohn, Mark A. Applebaum   +11 more
wiley   +1 more source

Application of the High-Throughput TAB-Array for the Discovery of Novel 5-Hydroxymethylcytosine Biomarkers in Pancreatic Ductal Adenocarcinoma

Epigenomes, 2019
The clinical outcomes of pancreatic ductal adenocarcinoma (PDAC) remain dismal, with an estimated five-year survival rate of less than 5%. Early detection and prognostic approaches, including robust biomarkers for PDAC, are critical for improving patient
Chang Zeng, Zhou Zhang, Jun Wang, Brian C-H Chiu, Lifang Hou, Wei Zhang   +5 more
doaj   +1 more source

Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase

Nature Biotechnology, 2018
Here we present APOBEC-coupled epigenetic sequencing (ACE-seq), a bisulfite-free method for localizing 5-hydroxymethylcytosine (5hmC) at single-base resolution with low DNA input.
Emily K. Schutsky, J. Denizio, Peng Hu, M. Liu, C. Nabel, Emily B Fabyanic, Y. Hwang, F. Bushman, Hao Wu, R. Kohli   +9 more
semanticscholar   +1 more source

iRNA5hmC: The First Predictor to Identify RNA 5-Hydroxymethylcytosine Modifications Using Machine Learning

Frontiers in Bioengineering and Biotechnology, 2020
RNA 5-hydroxymethylcytosine (5hmC) modification plays an important role in a series of biological processes. Characterization of its distributions in transcriptome is fundamentally important to reveal the biological functions of 5hmC.
Yuan Liu, Dasheng Chen, R. Su, Wei Chen, Leyi Wei   +4 more
semanticscholar   +1 more source