Results 11 to 20 of about 12,448,100 (233)

5-Hydroxymethylcytosine Loss in Conjunctival Melanoma [PDF]

Dermatopathology, 2021
Aims: Conjunctival and cutaneous melanoma partially share similar clinical and molecular backgrounds. As 5-hydroxymethylcytosine (5-hmC) loss has been demonstrated in cutaneous melanoma, we decided to assess if similar changes were occurring in ...
Alexandre Stahl, Nicolo Riggi, Katya Nardou, Michael Nicolas, Gurkan Kaya, Alexandre Moulin   +5 more
doaj   +5 more sources

5-Hydroxymethylcytosine (5-hmC) Specific Enrichment [PDF]

Bio-Protocol, 2012
5-Hydroxymethylcytosine (5-hmC) is a newly discovered DNA modification in mammalian genomes. This protocol is to be a highly efficient and selective chemical approach to label and capture 5-hmC, taking advantage of a bacteriophage enzyme that adds a ...
Keith Szulwach, Chun-Xiao Song, Chuan He, Peng Jin   +3 more
doaj   +3 more sources

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer

Cancer Research, 2022
In prostate cancer, 5-hydroxymethylcytosine delineates oncogene activation and stage-specific cell states and can be analyzed in liquid biopsies to detect cancer phenotypes.
M. Sjöström, Shuang G. Zhao, S. Levy, Meng Zhang, Y. Ning, Raunak Shrestha, Arian Lundberg, C. Herberts, A. Foye, R. Aggarwal, Junjie T Hua, Haolong Li, A. Bergamaschi, C. Maurice-Dror, Ashutosh Maheshwari, Sujun Chen, Sarah W. S. Ng, Wenbin Ye, Jessica Petricca, M. Fraser, Lisa N Chesner, M. Perry, Thaidy Moreno-Rodriguez, William S. Chen, J. Alumkal, J. Chou, A. Morgans, T. Beer, G. Thomas, M. Gleave, P. Lloyd, T. Phillips, E. McCarthy, Michael C. Haffner, A. Zoubeidi, Matti Annala, R. Reiter, M. Rettig, O. Witte, L. Fong, R. Bose, F. Huang, Jianhua Luo, A. Bjartell, J. Lang, N. Mahajan, P. Lara, C. Evans, P. Tran, E. Posadas, Chuan He, X. Cui, Jiaoti Huang, W. Zwart, Luke A. Gilbert, C. Maher, P. Boutros, K. Chi, Alan Ashworth, E. Small, H. He, A. Wyatt, D. Quigley, F. Feng   +63 more
semanticscholar   +7 more sources

5-Hydroxymethylcytosine signatures as diagnostic biomarkers for septic cardiomyopathy [PDF]

Scientific Reports
At present, there are currently no molecular biomarkers for the early diagnosis of sepsis cardiomyopathy (SCM) in clinical practice. This study focuses on an in-depth examination of the DNA hydroxymethylation profiles within plasma extracellular vesicles
Baixin Zhen, Zhiling Zhao, Hangyu Chen, Wen Li, Lei Zhang, Xi Zhu, Qinggang Ge, Jian Lin   +7 more
doaj   +2 more sources

Prediction of RNA 5-Hydroxymethylcytosine Modifications Using Deep Learning

IEEE Access, 2021
It is becoming increasingly clear that RNA 5-hydroxymethylcytosine (5hmC), which plays an important role in several biological processes, is one of the most important objects of study in the field of RNA epigenetics. Biochemical experiments using various
Syed Danish Ali, Jee Hong Kim, Hilal Tayara, Kil to Chong   +3 more
doaj   +2 more sources

Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation [PDF]

BMC Biology
Background Colorectal cancer (CRC) progression from adenoma to adenocarcinoma is associated with global reduction in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). DNA hypomethylation continues upon liver metastasis.
Ben Murcott, Floris Honig, Dominic Oliver Halliwell, Yuan Tian, James Lawrence Robson, Piotr Manasterski, Jennifer Pinnell, Thérèse Dix-Peek, Santiago Uribe-Lewis, Ashraf E. K. Ibrahim, Julia Sero, David Gurevich, Nikolas Nikolaou, Adele Murrell   +13 more
doaj   +2 more sources

The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. [PDF]

PLoS ONE, 2010
We recently showed that enzymes of the TET family convert 5-mC to 5-hydroxymethylcytosine (5-hmC) in DNA. 5-hmC is present at high levels in embryonic stem cells and Purkinje neurons.
Yun Huang, William A Pastor, Yinghua Shen, Mamta Tahiliani, David R Liu, Anjana Rao   +5 more
doaj   +5 more sources

Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expression. [PDF]

Nat Cell Biol
The conversion of DNA 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) by TET enzymes represents a significant epigenetic modification, yet its role in early human embryos remains largely unknown.
Liang D, Yan R, Long X, Ji D, Song B, Wang M, Zhang F, Cheng X, Sun F, Zhu R, Hou X, Wang T, Zou W, Zhang Y, Pu Z, Zhang J, Zhang Z, Liu Y, Hu Y, He X, Cao Y, Guo F.   +21 more
europepmc   +2 more sources

Formation and abundance of 5-hydroxymethylcytosine in RNA. [PDF]

ChemBioChem, 2015
RNA methylation is emerging as a regulatory RNA modification that could have important roles in the control and coordination of gene transcription and protein translation. Herein, we describe an in vivo isotope-tracing methodology to demonstrate that the
Bachman, Martin, Balasubramanian, Shankar, Huber, Sabrina M, Mendil, Lee, Miska, Eric A, Smollett, Katherine, van Delft, Pieter, Werner, Finn   +7 more
core   +5 more sources

5-Hydroxymethylcytosine is a predominantly stable DNA modification. [PDF]

Nature Chemistry, 2014
5-Hydroxymethylcytosine (hmC) is an oxidation product of 5-methylcytosine which is present in the deoxyribonucleic acid (DNA) of most mammalian cells. Reduction of hmC levels in DNA is a hallmark of cancers.
A Inoue, Adele Murrell, CG Lian, CG Spruijt, CX Song, D Globisch, DM Woodcock, EA Minor, GF Merrill, H Wu, J Otani, J Salvaing, JU Guo, JW Kappler, K Blaschke, K Iqbal, K Williams, L Shen, L Vassilev, L Wang, M Iurlaro, M Mellen, M Tahiliani, M Yu, Martin Bachman, MC Haffner, Michael Williams, MJ Booth, MM Dawlaty, QL Ying, RJ Klose, RM Kohli, RR Zhang, RS Hansen, S Ito, S Ito, S Kriaucionis, Santiago Uribe-Lewis, SG Jin, Shankar Balasubramanian, TF Kraus, Xiaoping Yang, Y Xu, YF He, YH Huh   +44 more
core   +5 more sources