Results 21 to 30 of about 12,448,100 (233)
5-Methylcytosine and 5-Hydroxymethylcytosine Signatures Underlying Pediatric Cancers [PDF]
Epigenomes, 2019 In addition to the genetic variations, recent evidence has shown that DNA methylation of both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) underlies the pathogenesis of pediatric cancer. Given the high mortality rate, there is an urgent need
Shalu Jhanwar, Ajinkya Deogade
doaj +4 more sources
Direct Sequencing of 5‐Methylcytosine and 5‐Hydroxymethylcytosine at Single‐Base Resolution Unravels Their Distinct Roles in Alzheimer's Disease [PDF]
Advanced ScienceAlzheimer's disease (AD) is associated with genetic risk factors and widespread epigenetic alterations. 5‐Hydroxymethylcytosine (5hmC), an oxidized derivative of 5‐methylcytosine (5mC), constitutes up to 20% of 5mC in neuronal DNA and is implicated in ...
Zi‐Xin Wang +15 more
doaj +2 more sources
Distribution of 5-Hydroxymethylcytosine in Different Human Tissues [PDF]
Journal of Nucleic Acids, 2011 5-hydroxymethylcytosine (5-hmC) is a modified form of cytosine recently found in mammalians and is believed, like 5-methylcytosine, to also play an important role in switching genes on and off.
Weiwei Li, Min Liu
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Cell-Free DNA 5-Hydroxymethylcytosine Signatures for Lung Cancer Prognosis [PDF]
CellsAccurate prognostic markers are essential for guiding effective lung cancer treatment strategies. The level of 5-hydroxymethylcytosine (5hmC) in tissue is independently associated with overall survival (OS) in lung cancer patients.
Jianming Shao +5 more
doaj +2 more sources
Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus [PDF]
, 2013 © 2013 Al-Mahdawi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are ...
A Dürr +41 more
core +16 more sources
5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme [PDF]
, 2015 5-hydroxymethylcytosine is a new epigenetic modification deriving from the oxidation of 5-methylcytosine by the TET hydroxylase enzymes. DNA hydroxymethylation drives DNA demethylation events and is involved in the control of gene expression ...
CAIAFA, Paola +3 more
core +12 more sources
Cancer Biology & Therapy, 2013 DNA methylation at the 5 position of cytosine (5-mC) has emerged as a key epigenetic marker that plays essential roles in various biological and pathological processes. 5-mC can be converted to 5-hydroxymethylcytosine (5-hmC) by the ten-eleven translocation (TET) family proteins, which is now widely recognized as the "sixth base" in the mammalian ...
Chao, Ye, Lan, Li
openaire +2 more sources
Journal of the American Chemical Society, 2023 Selective, efficient, and controllable oxidation of cytosine modifications is valuable for epigenetic analyses, yet only limited progress has been made.
Haiqi Xu +9 more
semanticscholar +1 more source
Cell Death and Disease, 2023 Multidrug resistance is a major challenge in treating advanced hepatocellular carcinoma (HCC). Although recent studies have reported that the multidrug resistance phenotype is associated with abnormal DNA methylation in cancer cells, the epigenetic ...
Xiaoen Guo +17 more
semanticscholar +1 more source
Hydroxymethylation profile of cell-free DNA is a biomarker for early colorectal cancer
Scientific Reports, 2022 Early detection of cancer will improve survival rates. The blood biomarker 5-hydroxymethylcytosine has been shown to discriminate cancer. In a large covariate-controlled study of over two thousand individual blood samples, we created, tested and explored
Nicolas J. Walker +44 more
doaj +1 more source