Results 71 to 80 of about 12,448,100 (233)

Regulation of 5-hydroxymethylcytosine by TET2 contributes to Squamous Cell Carcinoma tumorigenesis.

Journal of Investigative Dermatology, 2021
DNA methylation is a key regulatory event controlling a variety of physiological processes and can have dramatic effects on gene transcription. Methylated Cytosine (5mC) can be oxidized by the TET family of enzymes to 5-hydroxymethylcytosine (5-hmC), a ...
R. Boudra, Yvon Woappi, Diana Wang, Shuyun Xu, M. Wells, C. Schmults, C. Lian, M. R. Ramsey   +7 more
semanticscholar   +1 more source

Inadequate Zinc Intake in Adolescents Aggravates Inflammatory Bowel Disease by Inhibiting Antibody Class Switch Recombination in Mucosal B Cells Through Intestinal Microbial‐Derived KMV

iMetaMed, EarlyView.
The study reveals that inadequate zinc intake disrupts gut microbiota's ability to degrade isoleucine, leading to the accumulation of metabolite KMV. KMV inhibits antibody class‐switching in mucosal B cells by suppressing the p‐ATM‐CTIP‐Hmces pathway, impairing IgA/IgG production.
Wenbo Jiang, Yiding Geng, Bai Li, Conghui Qiao, Zijie Liu, Xinyu Shan, Xinyang Wang, Wei Wei, Tianshu Han   +8 more
wiley   +1 more source

Characterization of 5-methylcytosine and 5-hydroxymethylcytosine in human placenta cell types across gestation

Epigenetics, 2019
The placenta is an important organ in pregnancy, however, very little is understood about placental development at a molecular level. This includes the role of epigenetic mechanisms and how they change throughout gestation.
Rebecca L. Wilson, Maxime François, Tanja Jankovic-Karasoulos, Dale McAninch, Dylan McCullough, Wayne R. Leifert, Claire T. Roberts, Tina Bianco-Miotto   +7 more
doaj   +1 more source

Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research

Epigenetics, 2023
Background: Elucidating epigenetic mechanisms could provide new biomarkers for disease diagnosis and prognosis. Technological advances allow genome-wide profiling of 5-hydroxymethylcytosines (5hmC) in liquid biopsies.
Lu Gao, Zhou Zhang, Xiao-Long Cui, Diana West-Szymanski, Chang Ye, Chuan He, Wei Zhang, Marc Bissonnette   +7 more
doaj   +1 more source

The Hunt for 5-Hydroxymethylcytosine: The Sixth Base [PDF]

Epigenomics, 2011
transfers a glucose from UDP-glucose to 5-hmC in T4 bacteriophages. Two groups independently reported the use of b-GT to detect and quantify 5-hmC. Szwagierczak et al. used H radioactive glucose to label and quantify 5-hmC by scintillation counting [10]. Song et al.
Chun-Xiao, Song, Chuan, He
openaire   +2 more sources

Sequence based model using deep neural network and hybrid features for identification of 5-hydroxymethylcytosine modification

Scientific Reports
RNA modifications are pivotal in the development of newly synthesized structures, showcasing a vast array of alterations across various RNA classes. Among these, 5-hydroxymethylcytosine (5HMC) stands out, playing a crucial role in gene regulation and ...
Salman Khan, Islam Uddin, Mukhtaj Khan, Nadeem Iqbal, H. M. Alshanbari, Bakhtiyar Ahmad, Dost Muhammad Khan   +6 more
semanticscholar   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Methyltransferase‐Directed Derivatization of 5‐Hydroxymethylcytosine in DNA [PDF]

Angewandte Chemie International Edition, 2011
Cytosine modification by AdoMet–dependent DNA methyltransferases is part of an epigenetic regulatory network in vertebrates. Here we show that, in the absence of AdoMet, bacterial cytosine-5 methyltransferases can catalyze condensation of aliphatic thiols and selenols to 5-hydroxymethylcytosine in DNA yielding 5-chalcogenomethyl derivatives.
Zita, Liutkevičiūtė, Edita, Kriukienė, Indrė, Grigaitytė, Viktoras, Masevičius, Saulius, Klimašauskas   +4 more
openaire   +2 more sources

5-Hydroxymethylcytosine: the many faces of the sixth base of mammalian DNA.

Chemical Society Reviews
Epigenetic phenomena play a central role in cell regulatory processes and are important factors for understanding complex human disease. One of the best understood epigenetic mechanisms is DNA methylation.
Edita Kriukienė, M. Tomkuvienė, S. Klimašauskas   +2 more
semanticscholar   +1 more source

TET3‐Mediated m5C Modification of CCAT2 Accelerates Cardiac Microvascular Endothelial Cell Damage in Acute Coronary Syndrome

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS‐induced CMEC damage, thereby identifying a new target for ACS treatment. The expression of TET3 in ACS patients and healthy subjects was analyzed.
Jun‐Cheng Liu, Wen‐Juan Wang, Ting‐Ting Zhang, Qi‐Chong Yang, Haliminai Dilimulati, Song‐Tao An   +5 more
wiley   +1 more source