Results 91 to 100 of about 44,016 (219)
Cell Reports, 2015 The Tet family of methylcytosine dioxygenases (Tet1, Tet2, and Tet3) convert 5-methylcytosine to 5-hydroxymethylcytosine. To date, functional overlap among Tet family members has not been examined systematically in the context of embryonic development ...
Cheng Li +6 more
doaj +1 more source
Cytosine 5-Hydroxymethylation of the LZTS1 Gene Is Reduced in Breast Cancer [PDF]
, 2013 Change of DNA cytosine methylation (5mC) is an early event in the development of cancer, and the recent discovery of a 5-hydroxymethylated form (5hmC) of cytosine suggests a regulatory epigenetic role that might be different from 5-methylcytosine.
Matthias, Wielscher +7 more
core +1 more source
Cancer Science, EarlyView.We performed the first transcriptome‐wide profiling of m5C modifications in osteosarcoma, analyzing four pairs of tumor and adjacent normal tissues. We revealed that NSUN2 suppresses apoptosis in osteosarcoma cells by promoting GPRC5B m5C modification and expression.
Zhenyi Chen +10 more
wiley +1 more source
DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]
, 2018 DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola +3 more
core +1 more source
Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases
Cell Proliferation, EarlyView.Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long +6 more
wiley +1 more source
Insect Molecular Biology, EarlyView.Comparison between developmental stages (larvae, pupae, worker) in Pogonomyrmex californicus revealed significant stage‐specific differences in Gene Body Methylated frequencies. Methylation sites were highly correlated between WGBS and ONT in P. californicus Genome‐wide methylation was low (~3%) and highly clustered within gene bodies (GBM), especially
Tania Chavarria‐Pizarro +4 more
wiley +1 more source
Immunofluorescent staining reveals hypermethylation of microchromosomes in the central bearded dragon, Pogona vitticeps [PDF]
, 2018 BACKGROUND: Studies of model organisms have demonstrated that DNA cytosine methylation and histone modifications are key regulators of gene expression in biological processes.
Deakin, Janine E +4 more
core +1 more source
Resilient Biophysical Phenotype of Memory CD4+ T Cells in Long‐Lived Mice
Immunology, EarlyView.Aging is associated with increased stiffness and reduced migratory capacity of memory CD4+ T cells; however, these biophysical declines do not persist in exceptionally long‐lived mice. Instead, long‐lived individuals preserve T cell mechanics, migration and intracellular architecture, supporting mechanical resilience as a hallmark of successful immune ...
Aldo Abarca‐Ortega +6 more
wiley +1 more source
Nature CommunicationsDNA methylation plays an important role in various biological processes, including cell differentiation, ageing, and cancer development. The most important methylation in mammals is 5-methylcytosine mostly occurring in the context of CpG dinucleotides ...
Dominik Stanojević +4 more
doaj +1 more source
Aberrant gene-specific DNA methylation signature analysis in cervical cancer
Tumor Biology, 2017 Multicomponent molecular modifications such as DNA methylation may offer sensitive and specific cervical intraepithelial neoplasia and cervical cancer biomarkers.
Samatha Bhat +8 more
doaj +1 more source