Results 31 to 40 of about 44,016 (219)
Eicosapentaenoic acid induces DNA demethylation in carcinoma cells through a TET1-dependent mechanism [PDF]
, 2018 In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes.
Billi, Monia +9 more
core +1 more source
Sequence-selective 5-methylcytosine oxidation for epigenotyping [PDF]
Nucleic Acids Symposium Series, 2005 Methylation of DNA is an epigenetic modification that can play an important role in the control of gene expression in mammalian cells. The development of a simple and convenient method for site-specific discrimination of cytosine methylation is imperative for genomic studies.
Akimitsu, Okamoto, Kazuki, Tainaka
openaire +2 more sources
Advanced Science, 2023 Methylating RNA post‐transcriptionally is emerging as a significant mechanism of gene regulation in eukaryotes. The crosstalk between RNA methylation and histone modification is critical for chromatin state and gene expression in mammals.
Daolei Zhang +9 more
doaj +1 more source
Protein Interactions at Oxidized 5-Methylcytosine Bases
Journal of Molecular Biology, 2020 5-Methylcytosine (5mC), the major modified DNA base in mammalian cells, can be oxidized enzymatically to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) by the Ten-Eleven-Translocation (TET) family of proteins.
Pfeifer, Gerd P +2 more
openaire +5 more sources
Oxygenase Catalyzed 5-Methylcytosine Hydroxylation
Chemistry & Biology, 2009 Recent reports identify the oxygenase catalyzed production of 5-hydroxymethylcytosine as a modification to mammalian DNA (Kriaucionis and Heintz, 2009; Tahiliani et al., 2009). This discovery has potential far-reaching implications for epigenetic regulation and will stimulate efforts to identify new nucleic acid modifications.
Loenarz, C, Schofield, C
openaire +3 more sources
Discovery of a Bacterial 5-Methylcytosine Deaminase [PDF]
Biochemistry, 2014 5-Methylcytosine is found in all domains of life, but the bacterial cytosine deaminase from Escherichia coli (CodA) will not accept 5-methylcytosine as a substrate. Since significant amounts of 5-methylcytosine are produced in both prokaryotes and eukaryotes, this compound must eventually be catabolized and the fragments recycled by enzymes that have ...
Hitchcock, Daniel S. +4 more
openaire +2 more sources
UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures
Epigenetics, 2017 The 5-methylcytosine (5mC) modification regulates multiple cellular processes and is faithfully maintained following DNA replication. In addition to DNA methyltransferase (DNMT) family proteins, ubiquitin-like PHD and ring finger domain-containing ...
Yidan Liu +6 more
doaj +1 more source
Theoretical and experimental study of the vibrational spectra of 1.5-dimethylcytosine [PDF]
, 2008 The Raman spectra of the solid 1,5-dimethylcytosine and the FTIR spectra at room and low temperatures respectively have been registered. Quantum mechanical calculations of energies, geometries and vibrational wavenumbers were carried out by using ab ...
Ben Altabef, Aida +4 more
core +1 more source
Characterizing 5-methylcytosine in the mammalian epitranscriptome [PDF]
Genome Biology, 2013 The post-transcriptional modification 5-methylcytosine (m5C) occurs in a wide range of coding and non-coding RNAs. We describe transcriptome-wide approaches to capture the global m5C RNA methylome. We also discuss the potential functions of m5C in RNA and compare them to 6-methyladenosine modifications.
Hussain S +4 more
openaire +2 more sources
DNA 5-Methylcytosine-Specific Amplification and Sequencing
Journal of the American Chemical Society, 2020 DNA 5-methylcytosine (5mC)-specific mapping has been hampered by severe DNA degradation and the presence of 5-hydroxymethylcytosine (5hmC) using the conventional bisulfite sequencing approach. Here, we present a 5mC-specific whole-genome amplification method (5mC-WGA), with which we achieved 5mC retention during DNA amplification from limited input ...
Chang Liu +9 more
openaire +4 more sources