5-Methylcytosine RNA Methylation in Arabidopsis Thaliana [PDF]
Molecular Plant, 2017 5-Methylcytosine (m5C) is a well-characterized DNA modification, and is also predominantly reported in abundant non-coding RNAs in both prokaryotes and eukaryotes. However, the distribution and biological functions of m5C in plant mRNAs remain largely unknown.
Xuean, Cui +11 more
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Inhibition of DNA methyltransferase leads to increased genomic 5-hydroxymethylcytosine levels in hematopoietic cells. [PDF]
, 2018 5-Hydroxymethylcytosine (5hmC) is produced from 5-methylcytosine (5mC) by Ten-eleven translocation (TET) dioxygenases. The epigenetic modification 5hmC has crucial roles in both cellular development and differentiation.
Apró, Anna +9 more
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Detection of 5-methylcytosine in DNA sequences [PDF]
Nucleic Acids Research, 1978 Col E1 DNA has methylated cytosine in the sequence 5'-CC*(A/T)GG-3' and methylated adenine in the sequence 5'-GA*TC-3' at the positions indicated by asterisks(*). When the Maxam-Gilbert DNA sequencing method is applied to this DNA, the methylated cytosine (5-methylcytosine) is found to be less reactive to hydrazine than are cytosine and thymine, so ...
H, Ohmori, J I, Tomizawa, A M, Maxam
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5-hydroxymethylcytosine profiling as an indicator of cellular state [PDF]
, 2013 A Laird is supported by the Medical Research Council Scottish Clinical Pharmacology and Pathology Programme, The Royal College of Surgeons of Edinburgh Robertson’s Trust and The Melville Trust for the Care and Cure of Cancer.
Harrison, David J. +3 more
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Bacterial N4-methylcytosine as an epigenetic mark in eukaryotic DNA
Nature Communications, 2022 Eukaryotic DNA can be methylated as 5-methylcytosine and N6-methyladenine, but whether other forms of DNA methylation occur has been controversial. Here the authors show that a bacterial DNA methyltransferase was acquired >60 Mya in bdelloid rotifers ...
Fernando Rodriguez +3 more
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Oxidative damage to 5-methylcytosine in DNA [PDF]
Nucleic Acids Research, 1995 Exposure of pyrimidines of DNA to ionizing radiation under aerobic conditions or oxidizing agents results in attack on the 5,6 double bond of the pyrimidine ring or on the exocyclic 5-methyl group. The primary product of oxidation of the 5,6 double bond of thymine is thymine glycol, while oxidation of the 5-methyl group yields 5-hydroxymethyluracil ...
S, Zuo, R J, Boorstein, G W, Teebor
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5-methylcytosine turnover: Mechanisms and therapeutic implications in cancer
Frontiers in Molecular Biosciences, 2022 DNA methylation at the fifth position of cytosine (5mC) is one of the most studied epigenetic mechanisms essential for the control of gene expression and for many other biological processes including genomic imprinting, X chromosome inactivation and ...
Marion Turpin +3 more
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Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition
Nature Communications, 2017 Transcription activator-like effector proteins recognise specific DNA sequences via tandem repeats. Here the authors demonstrate TALEs can recognise the methylated bases 5mC and 5hmC, enabling them to detect epigenetic modifications.
Yuan Zhang +7 more
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5-Methylcytosine and 5-hydroxymethylcytosine spatiotemporal profiles in the mouse zygote.
PLoS ONE, 2012 BackgroundIn the mouse zygote, DNA methylation patterns are heavily modified, and differ between the maternal and paternal pronucleus. Demethylation of the paternal genome has been described as an active and replication-independent process, although the ...
Juliette Salvaing +5 more
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Cell-free DNA methylation as liquid biopsy for the assessment of fibrosis in patients with nonalcoholic steatohepatitis: a gap between innovation and implementation [PDF]
, 2017 The presence of cfDNA in the circulating compartment was demonstrated three decades ago , leading to the emergence of liquid biopsy.However, the implementation of cfDNA methylation as a non-invasive molecular tool for the diagnosis of fibrosis imposes ...
Pirola, Carlos José +1 more
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