Results 91 to 100 of about 8,386,191 (259)

Combination therapy with ruxolitinib plus low-dose cytarabine or mercaptopurine in patients with blast-phase myelofibrosis

Онкогематология, 2016
Patients with myelofibrosis in blast-phase commonly have a median overall survival of only 3–6 months. Given the older median age of onset and heavy pretreatment, intensive chemotherapy often is not appropriate and has low efficacy with high toxicity ...
M. S. Fominykh, V. A. Shuvaev, I. S. Martynkevich, L. B. Polushkina, V. Yu. Udal’eva, K. M. Abdulkadyrov   +5 more
doaj   +1 more source

Improvement in the Anticancer Activity of 6-Mercaptopurine via Combination with Bismuth(III).

Chemical and pharmaceutical bulletin, 2016
6-Mercaptopurine (6-MP) is a clinically important antitumor drug and its commercially available form is provided as monohydrate, belonging to biopharmaceuticals classification system (BCS) class II category. The combination of bismuth(III) (Bi(III)) with
Yang Yang, Shuang Zhou, Ruizhuo Ouyang, Yaoqin Yang, H. Tao, Kai Feng, Xiaoshen Zhang, Fei Xiong, Ning Guo, Tianyu Zong, P. Cao, Yuhao Li, Y. Miao   +12 more
semanticscholar   +1 more source

Vedolizumab for extraintestinal manifestations in pediatric inflammatory bowel disease: Results from the VedoKids study

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 2, Page 495-502, February 2026.
Abstract Extraintestinal manifestations (EIMs) manifest in 6%‐47% of patients with inflammatory bowel disease (IBD). Here, we characterize the course of EIMs in pediatric patients receiving vedolizumab included in the VedoKids cohort study. This was a subgroup analysis of the pediatric VedoKids cohort, a multicenter, prospective study of children (aged
Giulia D'Arcangelo, Dan Turner, Oren Ledder, Esther Orlanski‐Meyer, Efrat Broide, Maya Granot, Manar Matar, Seamus Hussey, Anat Yerushalmy‐Feler, Christoph Norden, Erasmo Miele, Marina Aloi   +11 more
wiley   +1 more source

Does CytoSorb Interfere with Immunosuppression? A Pharmacokinetic and Functional Evaluation

Pharmaceutics
Background/Objectives: Cytokine release during organ transplantation contributes to primary graft dysfunction and requires careful immunomodulation. CytoSorb, a hemoadsorption device developed to reduce circulating cytokine levels, is increasingly used ...
Stephan Harm, Claudia Schildböck, Denisa Cont, Viktoria Weber, Jens Hartmann   +4 more
doaj   +1 more source

Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes [PDF]

, 2014
Aim: We investigated candidate genes associated with thiopurine metabolism and clinical response in childhood acute lymphoblastic leukemia. Materials & methods: We performed genome-wide SNP association studies of 6-thioguanine and 6-mercaptopurine ...
Batzler, A., Cartwright, C.S., Fridley, B.L., Jenkins, G., Lennard, L., Li, F., Livshits, A., Matimba, A., Scully, S., Wang, L., Weinshilboum, R.   +10 more
core   +1 more source

Isolated gastrointestinal Langerhans cell histiocytosis in a 16‐month‐old child: A case report

JPGN Reports, Volume 7, Issue 1, Page 36-39, February 2026.
Abstract Langerhans cell histiocytosis (LCH) is a rare disorder characterized by clonal proliferation of Langerhans cells, most often involving the skin or bone. Isolated gastrointestinal (GI) involvement is extremely uncommon in young children. We report a 16‐month‐old girl with a 1‐month history of chronic vomiting, bloody diarrhea, and failure to ...
Al‐Qasim AL‐Bahlani, Laraib Touseeq, Mohammed Al‐Masqari, Emad Saad   +3 more
wiley   +1 more source

Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia [version 1; referees: 2 approved]

F1000Research, 2019
Fasting hypoglycemia is a known complication of mercaptopurine (6MP) maintenance therapy for acute lymphoblastic leukemia (ALL). It is associated with high levels of the methylated metabolite 6-methyl-mercaptopurine (6MMP).
Melissa Zhang, Bruce Bostrom
doaj   +1 more source

Inhibition of antibody production by thioinosine. 3. Studies on antibody biosynthesis [PDF]

, 1970
The effect of thioinosine on antibody response of immunized rabbits has been studied. When given simultaneously with the antigen, thioinosine profoundly suppresses the formation of humoral antibody.
Kumashiro, Kazuo, Ogata, Masana
core   +1 more source

Frequency and impact of repeat colonoscopy as a treat‐to‐target approach in pediatric inflammatory bowel disease

JPGN Reports, Volume 7, Issue 1, Page 70-76, February 2026.
Abstract Objectives Endoscopic healing (EH) is a treatment target in inflammatory bowel disease (IBD). However, adherence to repeat colonoscopy (RC) for EH assessment in pediatrics remains variable. We aimed to evaluate the frequency and timing of RC after diagnosis and its impact on treatment decisions at a large pediatric IBD center.
Kari Noel VanEvery, Grace Dukes, Brendan Boyle, Jennifer L. Dotson, Ross M. Maltz, Hilary K. Michel   +5 more
wiley   +1 more source

Optimization and validation of an RP-HPLC method for the estimation of 6-mercaptopurine in bulk and pharmaceutical formulations

Brazilian Journal of Pharmaceutical Sciences, 2014
A reverse phase HPLC method is described for the determination of 6-mercaptopurine in bulk and tablets. Chromatography was carried on a C18 column using a mixture of acetonitrile and 0.05 mol/L sodium acetate buffer (10:90 v/v) as the mobile phase at a ...
Vanita Somasekhar
doaj   +1 more source