Results 101 to 110 of about 8,386,191 (259)
Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients [PDF]
, 2016 Purpose: Methotrexate administration is associated with frequent adverse neurological events during treatment for childhood acute lymphoblastic leukemia.
Baird, Susan F. +5 more
core +2 more sources
Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.ABSTRACT Background The European ALLTogether protocol for childhood acute lymphoblastic leukemia, initiated in Sweden 2019, introduced earlier asparaginase during induction, dexamethasone instead of prednisone for all patients, and omitted anthracyclines from low‐risk induction to reduce treatment‐related toxicity.
Johannes Fermér +11 more
wiley +1 more source
BioImpacts, 2011 Introduction: 6-Mercaptopurine (6MP) is an important chemotherapeutic drug in the conventional treatment of childhood acute lymphoblastic leukemia (ALL).
Mohammad-Reza Rashidi +5 more
doaj +1 more source
In vitro responses to known in vivo genotoxic agents in mouse germ cells [PDF]
, 2017 YesGenotoxic compounds have induced DNA damage in male germ cells and have been associated with adverse clinical outcomes including enhanced risks for maternal, paternal and offspring health.
Anderson, Diana +2 more
core +1 more source
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Testing thiopurine methyltransferase (TPMT) enzyme activity or genotype prior to thiopurine prescribing is recommended to reduce the risk of moderate to severe—and potentially fatal—myelosuppression in poor or intermediate TPMT metabolizers. Despite this, only about one‐third of individuals prescribed thiopurines in Australia currently receive
Bella D. Ianni +4 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 2004 A procedure is described for the rapid determination of the intra-erythrocyte concentration of 6-mercaptopurine (6-MP) and its metabolites, 6-thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine (6-MMP).
B.M. Oliveira +4 more
doaj +1 more source
Historic landmarks in clinical transplantation: Conclusions from the consensus conference at the University of California, Los Angeles [PDF]
, 2000 The transplantation of organs, cells, and tissues has burgeoned during the last quarter century, with the development of multiple new specialty fields.
Brent, LB +11 more
core +1 more source
Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases.
Mohitosh Biswas +3 more
wiley +1 more source
South Asian Journal of Cancer, 2016 Introduction: Acute myeloid leukemia (AML) in elderly patients differs biologically from that in younger patients and is known to have unfavorable chromosomal rearrangements, higher resistance, and lower tolerance to chemotherapy.
Akhil Kapoor +5 more
doaj +1 more source
F1000Research, 2019 Fasting hypoglycemia is a known complication of mercaptopurine (6MP) maintenance therapy for acute lymphoblastic leukemia (ALL). It is associated with high levels of the methylated metabolite 6-methyl-mercaptopurine (6MMP).
Melissa Zhang, Bruce Bostrom
doaj +1 more source