[6]-Shogaol Attenuates Oxaliplatin-Induced Allodynia through Serotonergic Receptors and GABA in the Spinal Cord in Mice [PDF]
Pharmaceuticals, 2022 Although oxaliplatin is a well-known anti-cancer agent used for the treatment of colorectal cancer, treated patients often experience acute cold and mechanical allodynia as side effects. Unfortunately, no optimal treatment has been developed yet. In this
Suyong Kim +7 more
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Simultaneous Isolation of 6-Gingerol, 6-Shogaol, and 6-Paradol from Zingiber Officinale Using Vaccum Liquid Chromatography [PDF]
Sains Natural, 2022 Zingiber officinale (Ginger) was widely known as one of the most herbal medicines containing many bioactive compounds claimed to be useful as an antioxidant, anti-inflammatory, anti-cancer, and anti-coagulant.
Devi Permatasari +2 more
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BMC Complementary and Alternative Medicine, 2017 Background Ginger is a popular spice and food preservative. The rhizomes of the common ginger have been used as traditional medicine to treat various ailments.
Syntyche Ling Sing Seow +4 more
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6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress. [PDF]
PLoS ONE, 2012 6-Shogaol is an active compound isolated from Ginger (Zingiber officinale Rosc). In this work, we demonstrated that 6-shogaol induces apoptosis in human hepatocellular carcinoma cells in relation to caspase activation and endoplasmic reticulum (ER ...
Rong Hu +10 more
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Molecules, 2021 Acute kidney injury (AKI) is a dose-limiting side effect of cisplatin therapy in cancer patients. However, effective therapies for cisplatin-induced AKI are not available.
Mi-Gyeong Gwon +3 more
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Involvement of the Spinal Serotonergic System in the Analgesic Effect of [6]-Shogaol in Oxaliplatin-Induced Neuropathic Pain in Mice [PDF]
Pharmaceuticals, 2023 Oxaliplatin is a chemotherapy drug that can induce severe acute neuropathy in patients within hours of treatment. In our previous study, 10 mg/kg [6]-shogaol (i.p.) significantly alleviated cold and mechanical allodynia induced by a 6 mg/kg oxaliplatin ...
Juan Gang +3 more
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Pharmaceutics, 2019 ：6-shogaol is a promising anti-cancer and anti-inflammatory agent. However, the treatment effectiveness of 6-shogaol is limited by poor water solubility, poor oral absorption and rapid metabolism.
Jiangnan Yu, Wenwen Deng, Hui Yun Zhang
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Anticancer perspective of 6-shogaol: anticancer properties, mechanism of action, synergism and delivery system [PDF]
Chinese Medicine, 2023 Cancer is a malignant disease that has plagued human beings all the time, but the treatment effect of commonly used anticancer drugs in clinical practice is not ideal by reason of their drug tolerance and Strong adverse reactions to patients.
Yaoxia Jia +5 more
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Inhibitory effect of [6]-shogaol against 3CLpro activity and SARS-CoV-2 infection [PDF]
BMC Complementary Medicine and TherapiesBackground Zingiber officinale Roscoe (ginger) has been traditionally used not only as a culinary ingredient, but also for its medicinal properties.
Takashi Tanikawa +5 more
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Study on antihepatocellular carcinoma effect of 6-shogaol and curcumin through network-based pharmacological and cellular assay [PDF]
Frontiers in PharmacologyBackgroundHepatocellular carcinoma currently has the third highest mortality rate in the world. Patients with hepatocellular carcinoma are on the rise and at a younger age, but research into the pharmacological effects of cancer is mostly single ...
Qiuxia Jin +5 more
doaj +2 more sources