Examination of the protective effect of 6-shogaol against LPS-induced acute lung injury in mice via NF-kB attenuation [PDF]
Archives of Biological Sciences, 2016 Acute lung injury (ALI), the causative factor for acute respiratory distress syndrome, results in significant morbidity and mortality. Due to a lack of effective therapeutic options for ALI, the development of novel therapies is urgently needed.
Wang Jing-Chao +3 more
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Indonesian Journal of Chemistry, 2018 Ginger had been reported to ameliorate painful diabetic neuropathy (PDN) in an animal model. Gingerol and shogaol were active compounds of ginger that potentially act on transient receptor potential cation channel subfamily V member 1 (TRPV1), a key ...
Fifteen Aprila Fajrin +3 more
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, 2022 Rhizomes from Zingiber officinale Roscoe are traditionally used for the treatment of a plethora of pathophysiological conditions such as diarrhea, nausea, or rheumatoid arthritis.
Thomas Zech (12136062) +4 more
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Antioxidants, 2023 6-shogaol is a natural and the most potent bioactive vanilloid in dried Zingiber officinale rhizomes. Many scientific studies have reported the diverse biological activities of 6-shogaol.
Kit-Kay Mak +7 more
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Gingerol and shogaol on red ginger rhizome (Zingiber officinale var. Rubrum) using high-performance liquid chromatography [PDF]
Pharmaciana, 2023 Red ginger (Zingiber officinale var. Rubrum) is one of the traditional medicines of the Zingiberaceae family, which contains phenolic ketone compounds, including gingerol and shogaol.
Johan Sukweenadhi +4 more
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Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation. [PDF]
PLoS ONE, 2013 Our previous study found that [6]-shogaol, a major bioactive component in ginger, is extensively metabolized in cancer cells and in mice. It is unclear whether these metabolites retain bioactivity.
Yingdong Zhu +4 more
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Inhibition of Homodimerization of Toll-like Receptor 4 by 6-Shogaol
Molecules and Cells, 2009 Toll-like receptors (TLRs) play a critical role in sensing microbial components and inducing innate immune and inflammatory responses by recognizing invading microbial pathogens. Lipopolysaccharide-induced dimerization of TLR4 is required for the activation of downstream signaling pathways including nuclear factor-kappa B (NF-kappaB).
Sang-Il, Ahn +2 more
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Nine New Gingerols from the Rhizoma of Zingiber officinale and Their Cytotoxic Activities
Molecules, 2018 Nine new gingerols, including three 6-oxo-shogaol derivatives [(Z)-6-oxo-[6]-shogaol (1), (Z)-6-oxo-[8]-shogaol (2), (Z)-6-oxo-[10]-shogaol (3)], one 6-oxoparadol derivative [6-oxo-[6]-paradol (4)], one isoshogaol derivative [(E)-[4]-isoshogaol (5)], and
Zezhi Li +6 more
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Pharmacological studies on ginger. IV Effect of (6)-shogaol on the arachidonic cascade.
Folia Pharmacologica Japonica, 1986 (6)-Shogaol, a pungent component of ginger, which is contained in semi-dried ginger but is rarely found in fresh ginger inhibited carrageenin-induced swelling of hind paw in rats and arachidonic acid (AA)-induced platelet aggregation in rabbits. Moreover, (6)-shogaol prevented prostaglandin I2 (PGI2) release from the aorta of rats when tested as an ...
M, Suekawa +7 more
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Effect of 6-Shogaol Derived from Ginger (<i>Zingiber officinale</i>) on Dual-Species Biofilm Formation by <i>Streptococcus mutans</i> and <i>Candida albicans</i>. [PDF]
NutrientsBackground/Objectives: Dental plaque, a biofilm composed of accumulated oral microorganisms, is a key contributor to various oral diseases. 6-shogaol, a bioactive compound of ginger, is known to have pharmacological activities, including anticancer, anti-
Jung EH, Hwang G, Kim KR.
europepmc +2 more sources