Results 51 to 60 of about 9,551,377 (187)

Applying an Electrophilicity-Based Strategy to Develop a Novel Nrf2 Activator Inspired from Dietary [6]-Shogaol

open access: yes, 2018
Activation of nuclear factor erythroid-2-related factor 2 (Nrf2) is a crucial cellular defense mechanisms against oxidative stress and also an effective means to decrease the risk of oxidative stress-related diseases including cancer.
Ya-Long Zheng (5541182)   +5 more
core   +1 more source

6-Shogaol Inhibits Advanced Glycation End-Products-Induced IL-6 and ICAM-1 Expression by Regulating Oxidative Responses in Human Gingival Fibroblasts

open access: yesMolecules, 2019
Advanced glycation end-products (AGEs) cause diabetes mellitus (DM) complications and accumulate more highly in periodontal tissues of patients with periodontitis and DM.
Kohei Nonaka   +6 more
doaj   +1 more source

Functional diabetic biscuits enriched with cereal fibers, black plum (jamun) and bioactive spices

open access: yesFood Biomacromolecules, EarlyView.
Cereal fibres, black plum (jamun) seed powder and bioactive spices can be combined with controlled mixing, hydration and baking to design functional biscuits. Fibre‐rich structures may limit starch accessibility, while polyphenols may inhibit starch‐digesting enzymes.
Renukadevi Jeyavelkumaran   +3 more
wiley   +1 more source

Effects of shokyo (Zingiberis Rhizoma) and kankyo (Zingiberis Processum Rhizoma) on prostaglandin E2 production in lipopolysaccharide-treated mouse macrophage RAW264.7 cells [PDF]

open access: yesPeerJ, 2019
We previously reported that shokyo and kankyo, which are water-extracted fractions of ginger, reduced LPS-induced PGE2 production in human gingival fibroblasts.
Toshiaki Ara   +3 more
doaj   +2 more sources

Induction of apoptosis by 6-shogaol.

open access: yes, 2015
(A): DAPI staining showing condensed nuclei in MCF-7 cells in presence of the indicated concentrations of 6-shogaol after 48 hours and 72 hours. (B): Graph quantitates the percentage of apoptotic cells for each treatment and time points.
Anasuya Ray (793851)   +2 more
core   +1 more source

Pharmacokinetics of 6-shogaol, a pungent ingredient of Zingiberis Rhizoma, and the anti-inflammatory activity of its metabolite, 6-paradol [PDF]

open access: yes, 2013
Zingiberis Rhizoma の辛味成分である 6-shogaol およびその代謝物 6-paradol の体内動態および薬理活性について, 検討した。 6-shogaol (10 mg/kg) をラットに経口投与した際の血漿中 6-shogaol および 6-paradol 濃度を LC/MS/MSを用いて測定したところ, ともに投与 5 分後で Cmax に到達し, 投与 2 時間後までに速やかに血漿中から消失した。 代謝物である血漿中 6-paradol 濃度はいずれの採血時間においても,
Shimada, Tsutomu   +7 more
core   +1 more source

The Binding Prediction of 6-Paradol and its Derivatives on TRPV1 Agonist as a New Compound for Treating Painful Diabetic Neuropathy

open access: yesJurnal Ilmu Dasar, 2022
Ginger was reported to have a suppressive effect on pain in patients with Painful Diabetic Neuropathy (PDN). Our latest study revealed that 6-shogaol, one of the ginger components, had the best affinity in the Transient Receptor Potential Vanilloid 1 ...
Finas Rahmayanti   +2 more
doaj   +1 more source

Effects of ginger constituent 6‐shogaol on gastroesophageal vagal afferent C‐fibers [PDF]

open access: yesNeurogastroenterology & Motility, 2019
AbstractBackgroundGinger has been used as an herbal medicine worldwide to relieve nausea/vomiting and gastrointestinal discomfort, but the cellular and molecular mechanisms of its neuronal action remain unclear. The present study aimed to determine the effects of ginger constituent 6‐shogaol on gastroesophageal vagal nodose C‐fibers ...
Yongming Huang   +7 more
openaire   +2 more sources

Review of phytochemical and antioxidant properties of Ethiopian medicinal plants

open access: yesJSFA reports, EarlyView.
Abstract Ethiopia possesses a rich ethnobotanical heritage and diverse medicinal flora that play an important role in traditional healthcare. Many Ethiopian medicinal plants contain bioactive phytochemicals with potential antioxidant properties. This capital of indigenous knowledge has contributed to the documentation of different medicinal plants that
Endalamaw Yihune   +2 more
wiley   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

open access: yesPhytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca   +5 more
wiley   +1 more source

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