Results 21 to 30 of about 9,551,377 (187)

Research Progress on Antitumor Mechanism of 6-Shogaol

Shipin gongye ke-ji, 2023
The incidence and mortality of cancer are increasing year by year, which seriously threatens human health. 6-Shogaol, as one of the main active components in ginger, has become the focus of attention in recent years due to its advantages of safety and ...
Zhuan WANG, Hongliu HU, Qifeng CHEN, Jie ZHOU, Zhenzhen REN, Lihe JIANG   +5 more
doaj   +2 more sources

Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivatives. [PDF]

Molecules, 2022
Twenty newly synthesized derivatives of [6]-shogaol (4) were tested for inhibitory activity against histone deacetylases. All derivatives showed moderate to good histone deacetylase inhibition at 100 µM with a slightly lower potency than the lead compound.
Phaosiri C, Yenjai C, Senawong T, Senawong G, Saenglee S, Somsakeesit LO, Kumboonma P.   +6 more
europepmc   +4 more sources

6-Shogaol Ameliorates Liver Inflammation and Fibrosis in Mice on a Methionine- and Choline-Deficient Diet by Inhibiting Oxidative Stress, Cell Death, and Endoplasmic Reticulum Stress [PDF]

Molecules
Non-alcoholic steatohepatitis (NASH) is becoming an increasingly serious global health threat, distinguished by hepatic lipid accumulation, inflammation, and fibrosis.
Ah Young Yang, Kiryeong Kim, Hyun Hee Kwon, Jaechan Leem, Jeong Eun Song   +4 more
doaj   +2 more sources

Antibiofilm and Antivirulence Activities of 6-Gingerol and 6-Shogaol Against Candida albicans Due to Hyphal Inhibition [PDF]

Frontiers in Cellular and Infection Microbiology, 2018
Candida albicans is an opportunistic pathogen and responsible for candidiasis. C. albicans readily forms biofilms on various biotic and abiotic surfaces, and these biofilms can cause local and systemic infections. C.
Jin-Hyung Lee, Yong-Guy Kim, Pilju Choi, Jungyeob Ham, Jae Gyu Park, Jintae Lee   +5 more
doaj   +2 more sources

6-Shogaol Abrogates Parkinson’s Disease in Rotenone-Induced Rodents: Based on In Silico Study and Inhibiting TNF-α/NF-κB/IL-1β/MAO-B [PDF]

Pharmaceuticals
Background/Objectives: 6-Shogaol is a comparatively innovative anti-Parkinson’s remedy with antioxidant and anti-inflammatory characteristics. This investigation intended to determine the role of 6-shogaol in the Parkinson’s disease (PD) paradigm in ...
Misbahuddin Rafeeq, Fahad A. Al-Abbasi, Muhammad Afzal, Ehssan Moglad, Salwa D. Al-Qahtani, Sami I. Alzrea, Naif A. R. Almalki, Faisal Imam, Nadeem Sayyed, Imran Kazmi   +9 more
doaj   +2 more sources

Coadministration of 6-Shogaol and Levodopa Alleviates Parkinson's Disease-Related Pathology in Mice. [PDF]

Biomol Ther (Seoul)
Parkinson's disease (PD) is a neurodegenerative disease caused by the death of dopaminergic neurons in the nigrostriatal pathway, leading to motor and non-motor dysfunctions, such as depression, olfactory dysfunction, and memory impairment. Although levodopa (L-dopa) has been the gold standard PD treatment for decades, it only relieves motor symptoms ...
Kim JH, Kim JS, Ju IG, Huh E, Choi Y, Lee S, Cho JY, Park BY, Oh MS.   +8 more
europepmc   +3 more sources

Unraveling the interconversion pharmacokinetics and oral bioavailability of the major ginger constituents: [6]-gingerol, [6]-shogaol, and zingerone after single-dose administration in rats [PDF]

Frontiers in Pharmacology
BackgroundThe available in vitro evidences suggest the inherent instability and interconvertibility of [6]-gingerol and [6]-shogaol. However, limited data on their in vivo interconversion hinder understanding of their influence on the pharmacokinetic ...
Phanit Songvut, Watanyoo Nakareangrit, Wanida Cholpraipimolrat, Jackapun Kwangjai, Luksamee Worasuttayangkurn, Piyajit Watcharasit, Piyajit Watcharasit, Jutamaad Satayavivad, Jutamaad Satayavivad   +8 more
doaj   +2 more sources

6-shogaol against 3-Nitropropionic acid-induced Huntington's disease in rodents: Based on molecular docking/targeting pro-inflammatory cytokines/NF-κB-BDNF-Nrf2 pathway. [PDF]

PLoS ONE
BackgroundHuntington's disease (HD) is an extremely harmful autosomal inherited neurodegenerative disease. Motor dysfunction, mental disorder, and cognitive deficits are the characteristic features of this disease.
Ebtihaj J Jambi, Abdulaziz Alamri, Muhammad Afzal, Fahad A Al-Abbasi, Salwa D Al-Qahtani, Naif A R Almalki, Azizah Salim Bawadood, Sami I Alzarea, Nadeem Sayyed, Imran Kazmi   +9 more
doaj   +2 more sources

The therapeutic potential of naturally occurring 6-shogaol: an updated comprehensive review

Inflammopharmacology
Abstract Shogaol, a significant bioactive constituent of ginger, is present in several forms, including 4-, 6-, 8-, 10-, and 12-shogaol, with 6-shogaol identified as the most potent among them. Notably, 6-shogaol can be metabolized into 6-paradol, a compound that lacks pungency but retains biological activity. The primary focus of this review
Mai A Abd-Elmawla, Riham A El-Shiekh, Kareem Attallah   +2 more
exaly   +3 more sources

Metabolism of [6]-Shogaol in Mice and in Cancer Cells [PDF]

Drug Metabolism and Disposition, 2012
Ginger has received extensive attention because of its antioxidant, anti-inflammatory, and antitumor activities. However, the metabolic fate of its major components is still unclear. In the present study, the metabolism of [6]-shogaol, one of the major active components in ginger, was examined for the first time in mice and in cancer cells.
Huadong, Chen, Lishuang, Lv, Dominique, Soroka, Renaud F, Warin, Tiffany A, Parks, Yuhui, Hu, Yingdong, Zhu, Xiaoxin, Chen, Shengmin, Sang   +8 more
openaire   +3 more sources