Results 61 to 70 of about 1,351,533 (180)

Estrogenic, Genotoxic, and Antibacterial Effects of Chemicals from Cryogenically Milled Tire Tread

Environmental Toxicology and Chemistry, Volume 43, Issue 9, Page 1962-1972, September 2024.
Chemicals leaching from cryogenically milled tire tread detected by high‐performance thin‐layer chromatography bioassays. 6PPD = N‐(1,3‐dimethylbutyl)‐N′‐phenyl‐p‐phenylenediamine; DPG = diphenylguanidine. Abstract Tire and road wear particles (TRWP) contain complex mixtures of chemicals and release them to the environment, and potential toxic effects ...
Alan J. Bergmann, T. Masset, F. Breider, W. Dudefoi, K. Schirmer, B. J. D. Ferrari, E. L. M. Vermeirssen   +6 more
wiley   +1 more source

Interspecies Differences in 6PPD-Quinone Toxicity Across Seven Fish Species: Metabolite Identification and Semiquantification

, 2023
N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) is a recently identified contaminant that originates from the oxidation of the tire antidegradant 6PPD.
David Montgomery (12183442), Steve Wiseman (1445650), Jenna Cantin (1445638), Summer Selinger (12183445), Danielle Philibert (17551249), Markus Hecker (63819), Garrett Foster (17551252), Markus Brinkmann (469620), Benjamin de Jourdan (11804911), Justin Miller (1867006), Jenifer McIntyre (17551258), Xiaowen Ji (4235518), Niteesh Jain (17551255)   +12 more
core   +1 more source

Global multi-media distribution and transport of 6PPD and 6PPD-Q: a source-to-sink continuum

Environment International
The tire antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its toxic oxidation product 6PPD-quinone (6PPD-Q) are widely detected, yet their global cross-media distribution, transport patterns, and macroscopic anthropogenic ...
Yao Li, Qing Zhang, Wu Wen, Zhuangzhuang Zhang, Wenhao Xu, Yuan Xin, Jie Zhang, Xinghui Xia   +7 more
doaj   +1 more source

Acute Toxicity Testing of Pink Salmon (Oncorhynchus gorbuscha) with the Tire Rubber–Derived Chemical 6PPD‐Quinone

Environmental Toxicology and Chemistry, Volume 43, Issue 6, Page 1332-1338, June 2024.
Abstract N‐(1,3‐dimethylbutyl)‐N′‐phenyl‐p‐phenylenediamine‐quinone (6PPD‐quinone) is a widespread contaminant of emerging concern resulting from oxidation of 6PPD, which is an antidegradant substance added to tires. The recent identification of 6PPD‐quinone as the cause of acute mortality in coho salmon has quickly motivated studies on 6PPD‐quinone ...
Anders Foldvik, Fedor Kryuchkov, Eva Marita Ulvan, Roar Sandodden, Eli Kvingedal   +4 more
wiley   +1 more source

Watershed analysis of urban stormwater contaminant 6PPD-Quinone hotspots and stream concentrations using a process-based ecohydrological model

Frontiers in Environmental Science
Coho salmon (Oncorhynchus kisutch) are highly sensitive to 6PPD-Quinone (6PPD-Q). Details of the hydrological and biogeochemical processes controlling spatial and temporal dynamics of 6PPD-Q fate and transport from points of deposition to receiving ...
Jonathan J. Halama, Robert B. McKane, Bradley L. Barnhart, Paul P. Pettus, Allen F. Brookes, Angela K. Adams, Catherine K. Gockel, Kevin S. Djang, Vivian Phan, Sonali M. Chokshi, James J. Graham, Zhenyu Tian, Zhenyu Tian, Katherine T. Peter, Katherine T. Peter, Edward P. Kolodziej, Edward P. Kolodziej, Edward P. Kolodziej   +17 more
doaj   +1 more source

N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) induces osteoporosis by a mechanism involving CX43-mediated mitochondrial autophagy dysfunction in bone marrow mesenchymal stem cells

Ecotoxicology and Environmental Safety
As an emerging environmental contaminant, N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) poses a potential threat to public health. However, the potential link between 6PPD-Q exposure and bone health remains largely unexplored.
Haitao Zhang, Chaofeng Chen, Dayu Wang, Yiwei Huang, Yang Liu, Zhiyuan Wang, Furui Fu, Hongyu Wang, Senjie Shi, Yijin Li, Jianchun Zeng, Caiping Shen, Chudan Zhong, Xiaozhou Liu, Jinlun Chen, Jie Li, Shufen Liu, Jin Huang, Yirong Zeng, Wenjun Feng   +19 more
doaj   +1 more source

Exploring the mechanism of 6PPD/6PPD-Q-induced allergic rhinitis based on network toxicology, molecular docking, and molecular dynamic simulation

N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its ozonated derivative, 6PPD-quinone (6PPD-Q), are tire-derived contaminants with established aquatic toxicity, yet their role in respiratory allergies like Allergic Rhinitis (AR) remains ...
Wei Xia, Nan Shi, Anzhou Tang, Xuesong Wang, Jingyu Li, Xia Zhu   +5 more
core   +1 more source

Integrated machine learning and experimental validation reveal S6K2 as a key target of 6PPD-quinone in bladder cancer

Ecotoxicology and Environmental Safety
Tire and Road Wear Particles (TRWP) are pervasive environmental contaminants, yet the molecular mechanisms linking their toxic derivative, 6PPD-quinone (6PPD-Q), to bladder cancer (BLCA) progression remain obscure.
Jirong Wang, Meng Lu, Nienie Qi, Meng Zhang, Zixiang Li, Hailong Li, Junqi Wang   +6 more
doaj   +1 more source

Unveiling Underlying Mechanisms of Root Uptake, Bidirectional Translocation, and Biotransformation of Tire Rubber-Derived 6PPD and 6PPD-Q in Wheat ( Triticum aestivum L.): Implications by Nontarget Screening, Transcriptomics, and Molecular Docking

N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its derivative 6PPD-quinone (6PPD-Q) are emerging pollutants in the environment due to widespread usage of tire rubber-related products, yet their uptake, translocation, and biotransformation ...
Qiao Ma, Shuaihao Liu, Guangzhi Rong, Jingya Zhang, Aoduo Yang, Haixia Wang, Guoguang Wang, Qing Qin, Yu Liu, Haiyue Chen, Jiameng Hou   +10 more
core   +1 more source

Environmental behavior and the degradation of tire-rubber-related pollutant 6PPD-quinone in soils

Applied Biological Chemistry
N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q), a transformation product of the tire rubber antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine, has recently been identified as a contaminant of emerging concern due to its ...
Min-Young Kim, Ji-Young An, Deuk-Yeong Lee, Seong-Hoon Jeong, Jong-Hwan Kim   +4 more
doaj   +1 more source