Molecular Mechanisms of 6PPD and 6PPD-Q Toxicity in Neurodegenerative Diseases: A Network Toxicology and Experimental Validation Study [PDF]
Toxics6PPD is a widely used tire antioxidant that readily transforms into its more toxic ozonation product, 6PPD-quinone (6PPD-Q). Both compounds are emerging environmental contaminants with potential neurotoxic risks, yet their molecular mechanisms in ...
Ze Li +4 more
doaj +2 more sources
Tire-Derived Transformation Product 6PPD-Quinone Induces Mortality and Transcriptionally Disrupts Vascular Permeability Pathways in Developing Coho Salmon. [PDF]
Environ Sci Technol, 2023 Urban stormwater runoff frequently contains the car tire transformation product 6PPD-quinone, which is highly toxic to juvenile and adult coho salmon (Onchorychus kisutch). However, it is currently unclear if embryonic stages are impacted.
Greer JB, Dalsky EM, Lane RF, Hansen JD.
europepmc +4 more sources
Environment InternationalN-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) is commonly used in rubber compounds as antioxidants to protect against degradation from heat, oxygen, and ozone exposure.
Yang Jiang +4 more
doaj +2 more sources
Pilotstudie av analys av 6PPD och 6PPD-quinone i avloppsvatten
, 2023 Pilotstudie av analys av däckadditivet 6PPD och dess omvandlingsprodukt 6PPD-quinone (6PPDQ) i utgående vatten från de nio reningsverk som ingår i den årliga miljöövervakningen i avloppsreningsverk samt dagvattenprover före/efter rening vid två tillfällen (4 prover). Totalt analyserades 13 prover. Dessa ämnen är av intresse eftersom 6PPDQ har visat sig
Haglund, Peter
core +4 more sources
Para-phenylenediamines and their oxidative derivatives in infant formulas in China: Occurrence and health implications [PDF]
Food Chemistry: XPara-phenylenediamines (PPDs) and their quinone derivatives (PPD-Qs) are ubiquitous in the environment, while data on their occurrence in foods are scarce. In this study, twelve PPDs and PPD-Qs were measured in infant formula, and their daily intakes and
Zifu Shao, Chunyan Gao, Zhixiong Shi
doaj +2 more sources
What research exists on the presence of 6PPD-Q in different environmental media? A systematic map protocol [PDF]
Environmental EvidenceBackground Automobiles are ubiquitous in the modern world, and chemicals leaching from car tires and from the tire wear particles produced during driving can be toxic to the environment, particularly in aquatic ecosystems.
Sultan Aljohani +2 more
doaj +2 more sources
Effects of 6PPD-quinone on NLRP3 inflammasome formation
N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone, commonly called 6PPD-quinone (6PPD-Q), is an environmental transformation product formed when the antiozonant and antioxidant 6PPD, widely used in tires, reacts with ozone. 6PPD-Q enters the environment through tire wear particles and roadway runoff and has been linked to acute toxicity in ...
Holm, Matthew, Perujo Jurado, Yolanda
core +3 more sources
Environmental and Human Health Risks of 6PPD and 6PPDQ: Assessment and Implications [PDF]
ToxicsThis review aims to synthesize current knowledge on the environmental contaminants N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its quinone derivative (6PPDQ) derived from tire wear particles (TWPs), focusing on their environmental ...
Sainan Zhang +5 more
doaj +2 more sources
6PPD and 6PPD-Quinone in the Urban Environment: Assessing Exposure Pathways and Human Health Risks
Urban ScienceIn recent years, tires have become a prominent concern for researchers and environmentalists in regard to their potential threat of tire-derived pollutants (TDPs) to human health. Among these pollutants, N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine
Stanley Chukwuemeka Ihenetu +5 more
doaj +2 more sources
Environmental behavior and the degradation of tire-rubber-related pollutant 6PPD-quinone in soils
Applied Biological ChemistryN-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q), a transformation product of the tire rubber antioxidant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine, has recently been identified as a contaminant of emerging concern due to its ...
Min-Young Kim +4 more
doaj +2 more sources