Results 141 to 150 of about 37,102 (171)
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Oral Diseases
AbstractObjectiveDetermine the saliva and serum levels of neopterin (NP) and 7,8‐dihydroneopterin (7,8NP) in periodontitis patients and to reveal the relationship of these data with clinical periodontal parameters.Materials and MethodsTwenty‐three patients with stage III/grade B periodontitis and 23 periodontally healthy individuals were included ...
Emrah Turkmen +8 more
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AbstractObjectiveDetermine the saliva and serum levels of neopterin (NP) and 7,8‐dihydroneopterin (7,8NP) in periodontitis patients and to reveal the relationship of these data with clinical periodontal parameters.Materials and MethodsTwenty‐three patients with stage III/grade B periodontitis and 23 periodontally healthy individuals were included ...
Emrah Turkmen +8 more
openaire +3 more sources
The International Journal of Biochemistry & Cell Biology, 2021
Cluster of differentiation 36 (CD36) is a key scavenger receptor in the control of macrophage uptake of oxidised low-density lipoproteins (oxLDL). CD36 expression levels are not down regulated by intracellular cholesterol but are upregulated by oxidised low density lipoprotein (oxLDL) leading to the formation of lipid loaded foam cells, a major ...
Anthony Yeandle +3 more
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Cluster of differentiation 36 (CD36) is a key scavenger receptor in the control of macrophage uptake of oxidised low-density lipoproteins (oxLDL). CD36 expression levels are not down regulated by intracellular cholesterol but are upregulated by oxidised low density lipoprotein (oxLDL) leading to the formation of lipid loaded foam cells, a major ...
Anthony Yeandle +3 more
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Modulation of LDL Oxidation by 7,8-Dihydroneopterin
Free Radical Research, 2004Human macrophages stimulated with interferon-gamma generate neopterin and 7,8-dihydroneopterin which interfere with reactive species involved in LDL oxidation. While neopterin was found to have pro-oxidative effects on copper-mediated LDL oxidation, the influence of 7,8-dihydroneopterin is more complex. This study provides detailed information that 7,8-
Joachim Greilberger +4 more
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Spin Trapping Study of Antioxidant Properties of Neopterin and 7,8-Dihydroneopterin
Biochemical and Biophysical Research Communications, 1997Previously, it has been shown that pteridine derivatives are capable of modulating the action of free radicals and both prooxidant and antioxidant properties have been described. However, the mechanism of manifestation of these properties is still unclear. We studied the radical scavenging properties of 7,8-dihydroneopterin and neopterin using the spin
Sergey Dikalov +4 more
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Clinical Biochemistry, 2019
Knee arthroplasty surgery is significant trauma, leading to an activated immune system causing inflammation and oxidative stress. Many current biomarkers are invasive, costly, and often slow to analyse, limiting their use for rapid inflammatory measurements.We have examined the use of urinary neopterin and total neopterin in knee arthroplasty patients ...
Sean Cross +6 more
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Knee arthroplasty surgery is significant trauma, leading to an activated immune system causing inflammation and oxidative stress. Many current biomarkers are invasive, costly, and often slow to analyse, limiting their use for rapid inflammatory measurements.We have examined the use of urinary neopterin and total neopterin in knee arthroplasty patients ...
Sean Cross +6 more
openaire +4 more sources
Interference of 7,8-dihydroneopterin with peroxynitrite-mediated reactions
Biochemical and Biophysical Research Communications, 2004By in vitro studies 7,8-dihydroneopterin, which is secreted by macrophages stimulated by interferon-gamma, was reported to be a radical scavenger as well as a prooxidative agent depending on the experimental settings. In this study, we investigated the interference of 7,8-dihydroneopterin with peroxynitrite mediated reactions by different analytical ...
Joachim Greilberger +3 more
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Effects of neopterin and 7,8‐dihydroneopterin on hypoxia‐induced renal erythropoietin production
European Journal of Haematology, 1999Abstract: Activation of the human cellular immune system is associated with greatly increased formation of the pteridines neopterin and 7,8‐dihydroneopterin. It has been postulated that pteridines play a role in the pathogenesis of the anaemia of inflammation.
Joachim Fandrey +4 more
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Scandinavian Journal of Medicine & Science in Sports, 2015
Muscle damage caused through impacts in rugby union is known to increase oxidative stress and inflammation. Pterins have been used clinically as markers of oxidative stress, inflammation, and neurotransmitter synthesis. This study investigates the release of myoglobin from muscle tissue due to force‐related impacts and how it is related to the ...
John G. Lewis +8 more
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Muscle damage caused through impacts in rugby union is known to increase oxidative stress and inflammation. Pterins have been used clinically as markers of oxidative stress, inflammation, and neurotransmitter synthesis. This study investigates the release of myoglobin from muscle tissue due to force‐related impacts and how it is related to the ...
John G. Lewis +8 more
openaire +4 more sources
Free Radical Research, 2002
Low density lipoprotein (LDL) oxidation within the artery wall likely represents a key event in the formation of atherosclerotic lesions. Oxidatively modified LDL particles exert chemotactic properties on macrophages, and the uncontrolled uptake of modified LDL by macrophages leads to the formation of lipid-loaded foam cells, a hallmark of early stage ...
Joachim Greilberger +5 more
openaire +4 more sources
Low density lipoprotein (LDL) oxidation within the artery wall likely represents a key event in the formation of atherosclerotic lesions. Oxidatively modified LDL particles exert chemotactic properties on macrophages, and the uncontrolled uptake of modified LDL by macrophages leads to the formation of lipid-loaded foam cells, a hallmark of early stage ...
Joachim Greilberger +5 more
openaire +4 more sources
Dissociation of neopterin and 7,8-dihydroneopterin from plasma components before HPLC analysis
Journal of Chromatography B, 2008Measurement of plasma neopterin by HPLC with fluorescence detection is used clinically as a marker of immune cell activation in the management of a number of disease pathologies. HPLC analysis of neopterin requires the acidic removal of plasma proteins but we have found that 7,8-dihydroneopterin is oxidised to neopterin with varying yield.
Elizabeth M. Crone +3 more
openaire +4 more sources