Results 141 to 150 of about 37,816 (179)
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Protection of erythrocytes by the macrophage synthesized antioxidant 7,8 dihydroneopterin
Free Radical Research, 2001Neopterin and the reduced form, 7,8-dihydroneopterin (78NP) are pteridines released from macrophages when stimulated with gamma-interferon in vivo. The role of 78NP in inflammatory response is unknown though neopterin has been used clinically as a marker of immune cell activation, due to its very fluorescent nature.
S. Gieseg, G. Maghzal, Dylan M Glubb
semanticscholar +3 more sources
Formation of oxygen radicals in solutions of 7,8-dihydroneopterin.
Biochemical and Biophysical Research Communications, 1999Neopterin and 7,8-dihydroneopterin, two compounds which are secreted by activated macrophages, have been shown to interfere with radicals generated by cellular and certain chemical systems. Reduced pterins were reported to scavenge whereas aromatic pterins promoted or reduced radical mediated reactions or had no effect.
K. Oettl +5 more
semanticscholar +3 more sources
Modulation of LDL Oxidation by 7,8-Dihydroneopterin
Free Radical Research, 2004Human macrophages stimulated with interferon-gamma generate neopterin and 7,8-dihydroneopterin which interfere with reactive species involved in LDL oxidation. While neopterin was found to have pro-oxidative effects on copper-mediated LDL oxidation, the influence of 7,8-dihydroneopterin is more complex. This study provides detailed information that 7,8-
J. Greilberger +4 more
semanticscholar +3 more sources
Free Radical Research, 2020
7,8-Dihydroneopterin protects cells intracellularly from oxidative stress-induced death, but its mode of transport across the cell membrane is unknown. Nucleosides, such as guanosine, are transported via nucleoside transporters of the equilibrative and ...
Tejraj Janmale, A. Lindsay, S. Gieseg
semanticscholar +3 more sources
7,8-Dihydroneopterin protects cells intracellularly from oxidative stress-induced death, but its mode of transport across the cell membrane is unknown. Nucleosides, such as guanosine, are transported via nucleoside transporters of the equilibrative and ...
Tejraj Janmale, A. Lindsay, S. Gieseg
semanticscholar +3 more sources
Clinical Biochemistry, 2019
Knee arthroplasty surgery is significant trauma, leading to an activated immune system causing inflammation and oxidative stress. Many current biomarkers are invasive, costly, and often slow to analyse, limiting their use for rapid inflammatory measurements.We have examined the use of urinary neopterin and total neopterin in knee arthroplasty patients ...
Gregory Baxter-Parker +5 more
semanticscholar +3 more sources
Knee arthroplasty surgery is significant trauma, leading to an activated immune system causing inflammation and oxidative stress. Many current biomarkers are invasive, costly, and often slow to analyse, limiting their use for rapid inflammatory measurements.We have examined the use of urinary neopterin and total neopterin in knee arthroplasty patients ...
Gregory Baxter-Parker +5 more
semanticscholar +3 more sources
Spin trapping study of antioxidant properties of neopterin and 7,8-dihydroneopterin.
Biochemical and Biophysical Research Communications, 1997Previously, it has been shown that pteridine derivatives are capable of modulating the action of free radicals and both prooxidant and antioxidant properties have been described. However, the mechanism of manifestation of these properties is still unclear. We studied the radical scavenging properties of 7,8-dihydroneopterin and neopterin using the spin
K. Oettl +4 more
semanticscholar +3 more sources
Formation, Transport and Detection of 7,8-Dihydroneopterin [PDF]
, 2013 Atherosclerosis is a chronic inflammatory disease leading to plaque buildup in the major arteries. The plaques consist of cholesterol, calcium, inflammatory cells, extracellular matrix and fibrous material. Under inflammatory conditions IFN-• stimulation of human monocytes and macrophages generates reduced pteridine, 7,8-dihydroneopterin (78NP) which ...
Janmale, Tejraj Vijaykumar
openaire +4 more sources
Interference of 7,8-dihydroneopterin with peroxynitrite-mediated reactions.
Biochemical and Biophysical Research Communications, 2004By in vitro studies 7,8-dihydroneopterin, which is secreted by macrophages stimulated by interferon-gamma, was reported to be a radical scavenger as well as a prooxidative agent depending on the experimental settings. In this study, we investigated the interference of 7,8-dihydroneopterin with peroxynitrite mediated reactions by different analytical ...
K. Oettl +3 more
semanticscholar +3 more sources
Oral Diseases
OBJECTIVE Determine the saliva and serum levels of neopterin (NP) and 7,8-dihydroneopterin (7,8NP) in periodontitis patients and to reveal the relationship of these data with clinical periodontal parameters.
Emrah Turkmen +8 more
semanticscholar +3 more sources
OBJECTIVE Determine the saliva and serum levels of neopterin (NP) and 7,8-dihydroneopterin (7,8NP) in periodontitis patients and to reveal the relationship of these data with clinical periodontal parameters.
Emrah Turkmen +8 more
semanticscholar +3 more sources
Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from staphylococcus aureus
Nature Structural Biology, 1998Dihydroneopterin aldolase catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin during the de novo synthesis of folk acid from guanosine triphosphate. The gene encoding the dihydroneopterin aldolase from S. aureus has been cloned, sequenced and expressed in Escherichia coli.
M. Hennig +5 more
semanticscholar +2 more sources