Results 61 to 70 of about 37,816 (179)
Long-term correction of murine phenylketonuria by viral gene transfer: liver versus muscle [PDF]
, 2018 Current therapy for phenylketonuria (PKU) consists of life-long dietary restriction of phenylalanine (Phe), which presents problems of adherence for patients.
Thöny, Beat
core
The Plant Journal, Volume 119, Issue 5, Page 2464-2483, September 2024.SUMMARY The metabolism of tetrahydrofolate (H4PteGlun)‐bound one‐carbon (C1) units (C1 metabolism) is multifaceted and required for plant growth, but it is unclear what of many possible synthesis pathways provide C1 units in specific organelles and tissues.
Sompop Saeheng +8 more
wiley +1 more source
Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations [PDF]
, 2007 Background Folate synthesis and salvage pathways are relatively well known from classical biochemistry and genetics but they have not been subjected to comparative genomic analysis.
de Crécy-Lagard, Valérie +4 more
core +3 more sources
The FASEB Journal, Volume 38, Issue 16, 31 August 2024.The transcriptome and proteome changes caused by the overexpression of Maf1 in the protozoan parasite Leishmania major suggest the participation of this protein in multiple key biological processes. Abstract Maf1, originally described as a repressor of RNA polymerase III (RNAP III) transcription in yeast, participates in multiple functions across ...
Luis A. Rivera‐Rivas +7 more
wiley +1 more source
FEBS Letters, Volume 598, Issue 14, Page 1692-1714, July 2024.Traditional views of oxygen's role in evolution focus on improved energy yield in heterotrophic pathways. Before respiratory terminal oxidases arose, however, oxygen potently inhibited anaerobic growth, often by degrading FeS clusters. Several pathways for essential cofactors include enzymes with FeS clusters, selecting for alternative, oxygen‐tolerant
Natalia Mrnjavac +12 more
wiley +1 more source
Synthesis of queuine by colonic gut microbiome via cross‐feeding
Food Frontiers, Volume 5, Issue 1, Page 174-187, January 2024.Escherichia coli, Bacteroides fragilis, and Lactobacillus reuteri could independently synthesize Que in vitro. Abundance of Limosilactobacillus, Pediococcus, and Lactobacillus was increased by Que. Distribution of TGT, QueA, and QueG in microorganisms was changed by Que and bacteria.
Fujie Yan +3 more
wiley +1 more source
Mixotrophic growth under micro-oxic conditions in the purple sulfur bacterium "Thiodictyon syntrophicum" [PDF]
, 2019 The microbial ecosystem of the meromictic Lake Cadagno (Ticino, Swiss Alps) has been studied intensively in order to understand structure and functioning of the anoxygenic phototrophic sulfur bacteria community living in the chemocline. It has been found
Danza, Francesco +6 more
core +1 more source
Gene therapy for neurotransmitter‐related disorders
Journal of Inherited Metabolic Disease, Volume 47, Issue 1, Page 176-191, January 2024.Abstract Inborn errors of neurotransmitter (NT) metabolism are a group of rare, heterogenous diseases with predominant neurological features, such as movement disorders, autonomic dysfunction, and developmental delay. Clinical overlap with other disorders has led to delayed diagnosis and treatment, and some conditions are refractory to oral ...
Wing Sum Chu +3 more
wiley +1 more source
The Role of Urinary Pteridines as Disease Biomarkers [PDF]
, 2017 Pteridines and their derivatives function as intermediates in the metabolism of several vitamins and cofactors, and their relevance to disease has inspired new efforts to study their roles as disease biomarkers.
Burton, Casey, Ma, Yinfa
core +2 more sources
Urinary neopterin concentrations vs total neopterins for clinical utility [PDF]
, 1989 Fuchs D, Milstien S, Krämer A, et al. Urinary neopterin concentrations vs total neopterins for clinical utility. Clinical Chemistry. 1989;35(12):2305-2307.Neopterin measurements are especially useful as an early marker in (e.g.) allograft rejections and ...
Fuchs, Dietmar +7 more
core +1 more source