The FASEB Journal, Volume 38, Issue 16, 31 August 2024.The transcriptome and proteome changes caused by the overexpression of Maf1 in the protozoan parasite Leishmania major suggest the participation of this protein in multiple key biological processes. Abstract Maf1, originally described as a repressor of RNA polymerase III (RNAP III) transcription in yeast, participates in multiple functions across ...
Luis A. Rivera‐Rivas +7 more
wiley +1 more source
Localisation of antioxidants and oxidative markers within the atherosclerotic plaque [PDF]
, 2008 Atherosclerosis is a complex inflammatory disease in which oxidative stress is a major protagonist in the development and progression of the atherosclerotic plaque.
Flavall, Elizabeth A.
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An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae [PDF]
, 2017 Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded for high mortalities worldwide.
Azevedo, Vasco A.C. +13 more
core +8 more sources
Yeast derived metabolites and their impact on nutritional and bioactive properties of African fermented maize product [PDF]
, 2023 DATA AVAILABILITY : The research data is from literature sources.Fermented foods are an integral part of the diet for many communities in Africa. The fermentation of maize is characterized by an improved nutrient content/bioavailability and the presence ...
Kayitesi, Eugenie +2 more
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Synthesis of queuine by colonic gut microbiome via cross‐feeding
Food Frontiers, Volume 5, Issue 1, Page 174-187, January 2024.Escherichia coli, Bacteroides fragilis, and Lactobacillus reuteri could independently synthesize Que in vitro. Abundance of Limosilactobacillus, Pediococcus, and Lactobacillus was increased by Que. Distribution of TGT, QueA, and QueG in microorganisms was changed by Que and bacteria.
Fujie Yan +3 more
wiley +1 more source
[13c]-Constant-Time [15n,1h]-Trosy-Hnca for Sequential Assignments of Large Proteins [PDF]
, 2018 The greatly improved sensitivity resulting from the use of TROSY during 15N evolution and amide proton acquisition enables the recording of HNCA spectra of large proteins with constant-time 13Cα evolution. In [13C]-ct-[15N,1H]-TROSY-HNCA experiments with
Pervushin, Konstantin +4 more
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Gene therapy for neurotransmitter‐related disorders
Journal of Inherited Metabolic Disease, Volume 47, Issue 1, Page 176-191, January 2024.Abstract Inborn errors of neurotransmitter (NT) metabolism are a group of rare, heterogenous diseases with predominant neurological features, such as movement disorders, autonomic dysfunction, and developmental delay. Clinical overlap with other disorders has led to delayed diagnosis and treatment, and some conditions are refractory to oral ...
Wing Sum Chu +3 more
wiley +1 more source
Urinary neopterin concentrations vs total neopterins for clinical utility [PDF]
, 1989 Fuchs D, Milstien S, Krämer A, et al. Urinary neopterin concentrations vs total neopterins for clinical utility. Clinical Chemistry. 1989;35(12):2305-2307.Neopterin measurements are especially useful as an early marker in (e.g.) allograft rejections and ...
Fuchs, Dietmar +7 more
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Increasing Tetrahydrobiopterin in Cardiomyocytes Adversely Affects Cardiac Redox State and Mitochondrial Function Independently of Changes in NO Production [PDF]
, 2016 Tetrahydrobiopterin (BH4) represents a potential strategy for the treatment of cardiac remodeling, fibrosis and/or diastolic dysfunction. The effects of oral treatment with BH4 (Sapropterin™ or Kuvan™) are however dose-limiting with high dose negating ...
Bennett, Brian +5 more
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Long-term correction of murine phenylketonuria by viral gene transfer: liver versus muscle [PDF]
, 2018 Current therapy for phenylketonuria (PKU) consists of life-long dietary restriction of phenylalanine (Phe), which presents problems of adherence for patients.
Thöny, Beat
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