Results 71 to 80 of about 37,102 (171)

Chemoenzymatic Assembly of Isotopically Labeled Folates [PDF]

, 2017
Pterin-containing natural products have diverse functions in life but an efficient and easy scheme for their in vitro synthesis is not available. Here, we report a chemo-enzymatic 14-step, one-pot synthesis that can be used to generate 13C- and 15N ...
Antonio Angelastro, Curthoys N. P., E. Joel Loveridge, Fischer M., Gregory J. F., Gregory J. F., Griffin M. J., Louis Y. P. Luk, Mathis J. B., Rudolf K. Allemann, Schweitzer B. I., Sköld O., Suzuki Y., Weisman R. A., William M. Dawson, Yim J. J.   +15 more
core   +4 more sources

Role of neopterin and 7,8-dihydroneopterin in human immunodeficiency virus infection: marker for disease progression and pathogenic link.

Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology, 1996
Human immunodeficiency virus (HIV) infection is associated with increased concentrations of neopterin derivatives, released in large quantities by human macrophages on stimulation with interferon-gamma (INF-gamma). Neopterin concentrations thus inversely
G. Baier‐Bitterlich, H. Wachter, D. Fuchs   +2 more
semanticscholar   +1 more source

Lokiarchaeon is hydrogen dependent [PDF]

, 2016
The nature of host that acquired the mitochondrion at eukaryote origin (the host) is an important microbial evolutionary issue. Modern phylogenetics indicate that the host was an archaeon.
Allen, J, Allen, JF, Lane, N, Martin, WF, Neukirchen, S, Sousa, FL   +5 more
core   +1 more source

Cerebrospinal fluid neopterin analysis in neuropediatric patients: establishment of a new cut off-value for the identification of inflammatory-immune mediated processes [PDF]

, 2018
OBJECTIVE: A high level of cerebrospinal fluid (CSF) neopterin is a marker of central nervous system inflammatory-immune mediated processes. We aimed to assess data from 606 neuropediatric patients, describing the clinical and biochemical features of ...
Artuch Iriberri, Rafael, Cambra Lasaosa, Francisco José, Fernández-Ureña, Sergio, Garcia-Cazorla, Àngels, Jordán García, Iolanda, Molero Luis, Marta, Neopterin Workin Group, Ormazabal Herrero, Aida, Serrano, Mercedes   +8 more
core   +1 more source

Biochemical and structural characterisation of enzymes of the riboflavin- and folic acid biosynthesis [PDF]

, 2007
Die Riboflavinsynthase (RS) katalysiert den letzten Schritt der Riboflavinbiosynthese. Die gereinigte RS aus Schizosaccharomyces pombe wurde in Gegenwart von 6-Carboxyethyl-7-oxo-8-ribityllumazin kristalisiert und die Komplex-Struktur durch MAD gelöst ...
Schott, Anne-Kathrin
core  

Neopterin levels are independently associated with cardiac remodeling in patients with chronic heart failure [PDF]

, 2013
Neopterin, a marker of inflammation and monocyte activation, is found increased in patients with heart failure (HF). This study investigates whether neopterin levels correlate with left ventricular (LV) remodeling and brain natriuretic peptide (BNP), a ...
Belli, Oriana, Campolo, Jonica, Caruso, Raffaele, Cozzi, Lorena, De Chiara, Benedetta, Frigerio, Maria, Moreo, Antonella, Musca, Francesco, Parodi, Oberdan, Parolini, Marina, Verde, Alessandro   +10 more
core   +1 more source

The plant Nudix hydrolase family. [PDF]

, 2008
Nudix hydrolases are a family of proteins defined by a conserved amino-acid sequence GX(5)-EX(7)REUXEEXGU, where U is a hydrophobic residue. These enzymes are widely distributed among all classes of organisms and catalyze, with varying degrees of ...
Kraszewska, Elzbieta
core  

ResBoost: characterizing and predicting catalytic residues in enzymes [PDF]

, 2009
Background Identifying the catalytic residues in enzymes can aid in understanding the molecular basis of an enzyme's function and has significant implications for designing new drugs, identifying genetic disorders, and engineering proteins with novel ...
A Arvey, A del Sol Mesa, A Gutteridge, Aaron Arvey, B Ma, Carolina Dallett, CT Porter, DH Fong, E Rudiño-Piñera, E Youn, F Glaser, F Glaser, G Basarab, G Casari, G Nimrod, G Pugalenthi, G Weber, GJ Bartlett, H Berman, H Yao, I Mayrose, I Mihalek, J Blaszczyk, J Janin, J Liang, K Harata, KH Pearce Jr, Kimmen Sjölander, M Landau, M Lawrence, MJ Ondrechen, NV Petrova, O Lichtarge, P Aloy, R Apweiler, R Landgraf, R Laskowski, RA Laskowski, RC Edgar, RE Schapire, RE Schapire, RG Taylor, Ron Alterovitz, S Madabushi, S Phillips, S Sankararaman, SF Altschul, Sriram Sankararaman, TA Binkowski, W Tong, Y Freund, Y Freund, Y Freund, Y Wang, Yoav Freund, YR Tang   +55 more
core   +4 more sources

Radical-mediated ring contraction in the biosynthesis of 7-deazapurines [PDF]

, 2015
Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction ...
Bandarian, Vahe, Drennan, Catherine L.
core   +1 more source

Genetic and biotechnological characterization of folate-producing probiotics isolated from local dairy products

Beni-Suef University Journal of Basic and Applied Sciences
Background Folate is essential for Deoxyribonucleic acid (DNA) synthesis, methylation and repair, with deficiencies linked to neural tube defects, Alzheimer’s, and cancer.
Rahma Ali Hassan Abubakr, Mohammed Hassan Abdel A’al, Gihan Mohamed El Moghazy, Ashraf Bakry Abd Elrazik, Samir Abdel Aziz Ibrahim   +4 more
doaj   +1 more source