Results 1 to 10 of about 13,129 (133)

Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1[S] [PDF]

Journal of Lipid Research, 2014
Cytochrome P450 (P450 or CYP) 46A1 is expressed in brain and has been characterized by its ability to oxidize cholesterol to 24S-hydroxycholesterol. In addition, the same enzyme is known to further oxidize 24S-hydroxycholesterol to the 24,25- and 24,27 ...
Sandeep Goyal, Yi Xiao, Ned A. Porter, Libin Xu, F. Peter Guengerich   +4 more
doaj   +2 more sources

Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone [PDF]

Translational Psychiatry, 2022
Major depressive disorder (MDD) is a common, disabling, and heterogeneous condition that responds unpredictably to current treatments. We previously showed an association between depressive symptoms and plasma concentrations of two cholesterol precursors,
Basar Cenik, Jayme M. Palka, Bonne M. Thompson, Jeffrey G. McDonald, Carol A. Tamminga, Can Cenik, E. Sherwood Brown   +6 more
doaj   +2 more sources

Radiation-induced ferroptosis via liposomal delivery of 7-Dehydrocholesterol [PDF]

Journal of Nanobiotechnology
Background Ferroptosis is an emerging cell death mechanism characterized by uncontrolled lipid peroxidation. However, selectively inducing ferroptosis in cancer cells remains a challenge.
Jianwen Li, Shuyue Zhan, Wei Yang, He Zhang, Xinrui Ma, Fanghui Chen, Amy Li, Pakteema Tong, Fangchao Jiang, Zhengwei Cao, Ian Delahunty, Jiayi Wang, Yufei Wu, Zhi Liu, Zibo Li, Yong Teng, Libin Xu, Jin Xie   +17 more
doaj   +2 more sources

Identification and characterization of prescription drugs that change levels of 7-dehydrocholesterol and desmosterol [PDF]

Journal of Lipid Research, 2018
Regulating blood cholesterol (Chol) levels by pharmacotherapy has successfully improved cardiovascular health. There is growing interest in the role of Chol precursors in the treatment of diseases.
Phillip A. Wages, Hye-Young H. Kim, Zeljka Korade, Ned A. Porter   +3 more
doaj   +2 more sources

7-Dehydrocholesterol attenuates osteoarthritis by synergistically inhibiting oxidative stress, inflammation, and ferroptosis in macrophages [PDF]

Frontiers in Pharmacology
ObjectiveOsteoarthritis (OA) is a prevalent degenerative disorder affecting joints, characterized by progressive cartilage deterioration, inflammation of the synovium, and structural damage to subchondral bone.
Wenchao Zhang, Mengru Hua, Xinyu Zhao, Guangxin Sun, Yuheng Pan, Le Miao, Xuzhuo Chen, Xuzhuo Chen, Shanyong Zhang   +8 more
doaj   +2 more sources

On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO [PDF]

Journal of Lipid Research, 2014
A new mechanism for formation of 7-ketocholesterol was recently described involving cytochrome P-450 (CYP)7A1-catalyzed conversion of 7-dehydrocholesterol into 7-ketocholesterol with cholesterol-7,8-epoxide as a side product.
Ingemar Björkhem, Ulf Diczfalusy, Anita Lövgren-Sandblom, Lena Starck, Monica Jonsson, Keri Tallman, Henrik Schirmer, Lilian Bomme Ousager, Peter J. Crick, Yuqin Wang, William J. Griffiths, F. Peter Guengerich   +11 more
doaj   +2 more sources

Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey [PDF]

Molecules, 2020
20(S)-Hydroxyvitamin D3 (20(OH)D3) is an endogenous metabolite produced by the action of CYP11A1 on the side chain of vitamin D3 (D3). 20(OH)D3 can be further hydroxylated by CYP11A1, CYP27A1, CYP24A1 and/or CYP27B1 to several hydroxyderivatives. CYP11A1
Tae-Kang Kim, Venkatram Atigadda, Pawel Brzeminski, Adrian Fabisiak, Edith K. Y. Tang, Robert C. Tuckey, Andrzej T. Slominski   +6 more
doaj   +2 more sources

Metabolic engineering of Saccharomyces cerevisiae for 7-dehydrocholesterol overproduction [PDF]

Biotechnology for Biofuels, 2018
Background 7-Dehydrocholesterol (7-DHC) has attracted increasing attentions due to its great medical value and the enlarging market demand of its ultraviolet-catalyzed product vitamin D3.
Xiao-Jing Guo, Wen-Hai Xiao, Ying Wang, Ming-Dong Yao, Bo-Xuan Zeng, Hong Liu, Guang-Rong Zhao, Ying-Jin Yuan   +7 more
doaj   +2 more sources

Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis [PDF]

Nature Communications
Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver diseases; however, the organ-specific regulation mechanism is poorly understood.
Naoya Yamada, Tadayoshi Karasawa, Junya Ito, Daisuke Yamamuro, Kazushi Morimoto, Toshitaka Nakamura, Takanori Komada, Chintogtokh Baatarjav, Yuma Saimoto, Yuka Jinnouchi, Kazuhisa Watanabe, Kouichi Miura, Naoya Yahagi, Kiyotaka Nakagawa, Takayoshi Matsumura, Ken-ichi Yamada, Shun Ishibashi, Naohiro Sata, Marcus Conrad, Masafumi Takahashi   +19 more
doaj   +2 more sources

The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts. [PDF]

J Med Chem, 2016
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Korade Z, Kim HY, Tallman KA, Liu W, Koczok K, Balogh I, Xu L, Mirnics K, Porter NA.   +8 more
europepmc   +3 more sources