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A-to-I RNA editing: The “ADAR” side of human cancer
Seminars in Cell & Developmental Biology, 2012Carcinogenesis is a complex, multi-stage process depending on both endogenous and exogenous factors. In the past years, DNA mutations provided important clues to the comprehension of the molecular pathways involved in numerous cancers. Recently, post-transcriptional modification events, such as RNA editing, are emerging as new players in several human ...
Galeano, Federica +3 more
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Bioinformatic Approaches for Identification of A-to-I Editing Sites
2011The first discoveries of mammalian A-to-I RNA editing have been serendipitous. In conjunction with the fast advancement in sequencing technology, systematic methods for prediction and detection of editing sites have been developed, leading to the discovery of thousands of A-to-I editing sites.
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Perturbing A-to-I RNA Editing Using Genetics and Homologous Recombination
2011Evidence for the chemical conversion of adenosine-to-inosine (A-to-I) in messenger RNA (mRNA) has been detected in numerous metazoans, especially those "most successful" phyla: Arthropoda, Mollusca, and Chordata. The requisite enzymes for A-to-I editing, ADARs (adenosine deaminases acting on RNA) are highly conserved and are present in every higher ...
Cynthia J, Staber +3 more
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An uneven race: genome editing for parasitic worms
Nature Reviews Microbiology, 2021Matt Berriman, Gabriel Rinaldi
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Structural biology of CRISPR–Cas immunity and genome editing enzymes
Nature Reviews Microbiology, 2022Joy Y Wang +2 more
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Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
Cell, 2021Peter J Chen +2 more
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Base editing: advances and therapeutic opportunities
Nature Reviews Drug Discovery, 2020Alexis C Komor, Gene W Yeo
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Base editing of organellar DNA with programmable deaminases
Nature Reviews Molecular Cell Biology, 2023Jin-Soo Kim, Jia Chen
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Engineered materials for in vivo delivery of genome-editing machinery
Nature Reviews Materials, 2019Sheng Tong, Buhle Moyo, Ciaran M Lee
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Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation
Nature Reviews Molecular Cell Biology, 2015Antonia A Dominguez +2 more
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