Results 41 to 50 of about 1,508,590 (281)
Systematically Characterizing A-to-I RNA Editing Neoantigens in Cancer [PDF]
Frontiers in Oncology, 2020 A-to-I RNA editing can contribute to the transcriptomic and proteomic diversity of many diseases including cancer. It has been reported that peptides generated from RNA editing could be naturally presented by human leukocyte antigen (HLA) molecules and elicit CD8+ T cell activation.
Chi Zhou +4 more
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Do RNA modifications contribute to modulation of immune responses in allergic diseases?
Frontiers in Allergy, 2023 RNA modifications have emerged as a fundamental mechanism of post-transcriptional gene regulation, playing vital roles in cellular physiology and the development of various diseases.
Pavel Kudrin, Ana Rebane
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Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system
Frontiers in Neuroscience, 2013 The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal responsiveness during development and in maintaining the stability of established networks in the face of altered sensory input.
Andrew Charles Penn +3 more
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REDIportal: millions of novel A-to-I RNA editing events from thousands of RNAseq experiments
Nucleic Acids Res., 2020 RNA editing is a relevant epitranscriptome phenomenon able to increase the transcriptome and proteome diversity of eukaryotic organisms. ADAR mediated RNA editing is widespread in humans in which millions of A-to-I changes modify thousands of primary ...
L. Mansi +9 more
semanticscholar +1 more source
A-to-I RNA editing – thinking beyond the single nucleotide [PDF]
RNA Biology, 2017 Adenosine-to-inosine RNA editing is a conserved process, which is performed by ADAR enzymes. By changing nucleotides in coding regions of genes and altering codons, ADARs expand the cell's protein repertoire. This function of the ADAR enzymes is essential for human brain development. However, most of the known editing sites are in non-coding repetitive
Nabeel S. Ganem, Ayelet T. Lamm
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An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization
Cells, 2019 Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide.
Reginald V.C.T. van der Kwast +2 more
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Microbiology Spectrum, 2021 Iron is an essential element for the growth and survival of pathogenic bacteria; however, it is not fully understood how bacteria sense and respond to iron deficiency or excess. In this study, we show that xfeA in Xanthomonas oryzae pv.
Wenhan Nie +14 more
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Altered A-to-I RNA Editing in Human Embryogenesis
PLoS ONE, 2012 Post-transcriptional events play an important role in human development. The question arises as to whether Adenosine to Inosine RNA editing, catalyzed by the ADAR (Adenosine Deaminase acting on RNA) enzymes, differs in human embryogenesis and in adulthood.
Ronit Shtrichman +9 more
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Molecular Therapy: Nucleic AcidsRNA editing, a common and potentially highly functional form of RNA modification, encompasses two different RNA modifications, namely adenosine to inosine (A-to-I) and cytidine to uridine (C-to-U) editing. As inosines are interpreted as guanosines by the
Korina Karagianni +12 more
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A-to-I RNA editing and hematopoiesis
Experimental HematologyAdenosine-to-inosine (A-to-I) RNA editing plays essential roles in modulating normal development and homeostasis. This process is catalyzed by adenosine deaminase acting on RNA (ADAR) family proteins. The most well-understood biological processes modulated by A-to-I editing are innate immunity and neurological development, attributed to ADAR1 and ADAR2,
Zhen, Liang +2 more
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