Comparative RNA editing in autistic and neurotypical cerebella [PDF]
, 2012 Adenosine-to-inosine (A-to-I) RNA editing is a neurodevelopmentally regulated epigenetic modification shown to modulate complex behavior in animals.
Brown, Emery N. +11 more
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Type-Directed Program Transformations for the Working Functional Programmer [PDF]
, 2020 We present preliminary research on Deuce+, a set of tools integrating plain text editing with structural manipulation that brings the power of expressive and extensible type-directed program transformations to everyday, working programmers without a ...
Chugh, Ravi, Lubin, Justin
core +1 more source
A-to-I RNA editing – thinking beyond the single nucleotide [PDF]
RNA Biology, 2017 Adenosine-to-inosine RNA editing is a conserved process, which is performed by ADAR enzymes. By changing nucleotides in coding regions of genes and altering codons, ADARs expand the cell's protein repertoire. This function of the ADAR enzymes is essential for human brain development. However, most of the known editing sites are in non-coding repetitive
Nabeel S. Ganem, Ayelet T. Lamm
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An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization
Cells, 2019 Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide.
Reginald V.C.T. van der Kwast +2 more
doaj +1 more source
Do RNA modifications contribute to modulation of immune responses in allergic diseases?
Frontiers in Allergy, 2023 RNA modifications have emerged as a fundamental mechanism of post-transcriptional gene regulation, playing vital roles in cellular physiology and the development of various diseases.
Pavel Kudrin, Ana Rebane
doaj +1 more source
RNA editing regulates insect gamma-aminobutyric acid receptor function and insecticide sensitivity [PDF]
, 2008 A-to-I pre-mRNA editing by adenosine deaminase enzymes has been reported to enhance protein diversity in the nervous system. In Drosophila, the resistance to dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor subunit displays an editing site (R122 ...
A. Hamon +3 more
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Systematic identification of edited microRNAs in the human brain [PDF]
, 2012 Adenosine-to-inosine (A-to-I) editing modifies RNA transcripts from their genomic blueprint. A prerequisite for this process is a double-stranded RNA (dsRNA) structure.
Alon, Shahar +8 more
core +1 more source
Harnessing the Potential of Human Pluripotent Stem Cells and Gene Editing for the Treatment of Retinal Degeneration [PDF]
, 2017 PURPOSE OF REVIEW: A major cause of visual disorders is dysfunction and/or loss of the light-sensitive cells of the retina, the photoreceptors. To develop better treatments for patients, we need to understand how inherited retinal disease mutations ...
Ali, RR +4 more
core +1 more source
Altered A-to-I RNA Editing in Human Embryogenesis
PLoS ONE, 2012 Post-transcriptional events play an important role in human development. The question arises as to whether Adenosine to Inosine RNA editing, catalyzed by the ADAR (Adenosine Deaminase acting on RNA) enzymes, differs in human embryogenesis and in adulthood.
Ronit Shtrichman +9 more
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A-to-I editing of the 5HT2C receptor and behaviour [PDF]
Briefings in Functional Genomics and Proteomics, 2006 Site-specific deamination of five adenosine residues in the pre-mRNA of the serotonin 2C receptor, 5HT2CR, alters the amino acid sequence of the encoded protein. Such RNA editing can produce 32 mRNA variants, encoding 24 protein isoforms that vary in biochemical and pharmacological properties.
Katheleen, Gardiner, Yunzhi, Du
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