Advances in A-to-I RNA editing in cancer [PDF]
Molecular CancerRNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers.
Yi Zhang +9 more
doaj +4 more sources
DeepEdit: single-molecule detection and phasing of A-to-I RNA editing events using nanopore direct RNA sequencing [PDF]
Genome Biology, 2023 Single-molecule detection and phasing of A-to-I RNA editing events remain an unresolved problem. Long-read and PCR-free nanopore native RNA sequencing offers a great opportunity for direct RNA editing detection.
Longxian Chen +9 more
doaj +4 more sources
The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers [PDF]
Genomics, Proteomics & Bioinformatics, 2023 Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers.
Sijia Wu +4 more
doaj +2 more sources
Profiling A-to-I RNA editing during mouse somatic reprogramming at the single-cell level [PDF]
Heliyon, 2023 Mouse somatic cells can be reprogrammed into induced pluripotent stem cells through a highly heterogeneous process regulated by numerous biological factors, including adenosine-to-inosine (A-to-I) RNA editing.
Tianhang Lv +3 more
doaj +2 more sources
Uncovering Cis-Regulatory Elements Important for A-to-I RNA Editing in Fusarium graminearum [PDF]
mBio, 2022 Adenosine-to-inosine (A-to-I) RNA editing independent of adenosine deaminase acting on RNA (ADAR) enzymes was discovered in fungi recently, and shown to be crucial for sexual reproduction. However, the underlying mechanism for editing is unknown.
Chanjing Feng +8 more
doaj +2 more sources
Host A-to-I RNA editing signatures in intracellular bacterial and single-strand RNA viral infections [PDF]
Frontiers in Immunology, 2023 BackgroundMicrobial infection is accompanied by remodeling of the host transcriptome. Involvement of A-to-I RNA editing has been reported during viral infection but remains to be elucidated during intracellular bacterial infections.ResultsHerein we ...
Zhi-Yuan Wei +30 more
doaj +2 more sources
Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites [PDF]
FlyAdenosine-to-inosine (A-to-I) RNA editing recodes the genome and confers flexibility for the organisms to adapt to the environment. It is believed that RNA recoding sites are well suited for facilitating adaptive evolution by increasing the proteomic ...
Yuange Duan +8 more
doaj +2 more sources
Multimodal CRISPR screens uncover DDX39B as a global repressor of A-to-I RNA editing [PDF]
Cell ReportsSummary: Adenosine-to-inosine (A-to-I) RNA editing is a critical post-transcriptional modification that diversifies the transcriptome and influences various cellular processes, yet its regulatory mechanisms remain largely unknown.
Tianzi Wei +7 more
doaj +2 more sources
An orthology-based methodology as a complementary approach to retrieve evolutionarily conserved A-to-I RNA editing sites [PDF]
RNA BiologyAdar-mediated adenosine-to-inosine (A-to-I) mRNA editing is a conserved mechanism that exerts diverse regulatory functions during the development, evolution, and adaptation of metazoans.
Jiyao Liu +8 more
doaj +2 more sources
Landscape of A-I RNA editing in mouse, pig, macaque, and human brains. [PDF]
Nucleic Acids ResLi C +14 more
europepmc +3 more sources