The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers [PDF]
Genomics, Proteomics & Bioinformatics, 2023 Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers.
Sijia Wu +4 more
doaj +2 more sources
Profiling A-to-I RNA editing during mouse somatic reprogramming at the single-cell level [PDF]
Heliyon, 2023 Mouse somatic cells can be reprogrammed into induced pluripotent stem cells through a highly heterogeneous process regulated by numerous biological factors, including adenosine-to-inosine (A-to-I) RNA editing.
Tianhang Lv +3 more
doaj +2 more sources
Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites [PDF]
FlyAdenosine-to-inosine (A-to-I) RNA editing recodes the genome and confers flexibility for the organisms to adapt to the environment. It is believed that RNA recoding sites are well suited for facilitating adaptive evolution by increasing the proteomic ...
Yuange Duan +8 more
doaj +2 more sources
Advances in A-to-I RNA editing in cancer [PDF]
Molecular CancerRNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers.
Yi Zhang +9 more
doaj +2 more sources
An orthology-based methodology as a complementary approach to retrieve evolutionarily conserved A-to-I RNA editing sites [PDF]
RNA BiologyAdar-mediated adenosine-to-inosine (A-to-I) mRNA editing is a conserved mechanism that exerts diverse regulatory functions during the development, evolution, and adaptation of metazoans.
Jiyao Liu +8 more
doaj +2 more sources
Adaptation of A-to-I RNA editing in bacteria, fungi, and animals [PDF]
Frontiers in Microbiology, 2023 Yuange Duan, Hu Li, Wanzhi Cai
doaj +2 more sources
Ocular A-to-I RNA editing signatures associated with SARS-CoV-2 infection [PDF]
BMC GenomicsOphthalmic manifestations have recently been observed in acute and post-acute complications of COVID-19 caused by SARS-CoV-2 infection. Our precious study has shown that host RNA editing is linked to RNA viral infection, yet ocular adenosine to inosine ...
Yun-Yun Jin +8 more
doaj +2 more sources
The Many Roles of A-to-I RNA Editing in Animals: Functional or Adaptive?
Frontiers in Bioscience-Landmark, 2023 Metazoan adenosine-to-inosine (A-to-I) RNA editing is a highly conserved mechanism that diversifies the transcriptome by post-transcriptionally converting adenosine to inosine.
Dongwu Zhan +4 more
doaj +1 more source
L-GIREMI uncovers RNA editing sites in long-read RNA-seq
Genome Biology, 2023 Although long-read RNA-seq is increasingly applied to characterize full-length transcripts it can also enable detection of nucleotide variants, such as genetic mutations or RNA editing sites, which is significantly under-explored.
Zhiheng Liu +7 more
doaj +1 more source
Uncovering Cis-Regulatory Elements Important for A-to-I RNA Editing in Fusarium graminearum
mBio, 2022 Adenosine-to-inosine (A-to-I) RNA editing independent of adenosine deaminase acting on RNA (ADAR) enzymes was discovered in fungi recently, and shown to be crucial for sexual reproduction. However, the underlying mechanism for editing is unknown.
Chanjing Feng +8 more
doaj +1 more source