Results 1 to 10 of about 515,927 (320)
The cell line A-to-I RNA editing catalogue [PDF]
Nucleic Acids Research, 2020 Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory ...
Eisenberg E. +5 more
core +7 more sources
A-to-I RNA editing in the earliest-diverging Eumetazoan phyla [PDF]
Molecular Biology and Evolution, 2017 © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology and Evolution 34 (2017): 1890-1901, doi:10.1093/molbev/msx125.The highly conserved ...
Alon, Shahar +7 more
core +7 more sources
Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]
Frontiers in Neuroscience, 2013 The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal signaling during development and in maintaining the stability of established networks in the face of altered sensory input.
Andrew C. Penn +2 more
core +5 more sources
A-to-I RNA Editing and Human Disease [PDF]
RNA Biology, 2006 The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has been recognized as an important mechanism for the generation of molecular diversity and also regulates protein function through recoding of genomic information.
Stefan Maas +3 more
semanticscholar +5 more sources
Substitutional A‐to‐I RNA editing [PDF]
WIREs RNA, 2010 AbstractAdenosine‐to‐inosine (A‐to‐I) editing catalyzed by adenosine deaminases acting on RNA (ADARs) entails the chemical conversion of adenosine residues to inosine residues within double‐stranded RNA (dsRNA) substrates. Inosine base pairs as guanosine and A‐to‐I editing can therefore alter the structure and base pairing properties of the RNA ...
Bjorn‐Erik Wulff, Kazuko Nishikura
semanticscholar +5 more sources
Expanding the proteome: A-to-I RNA editing provides an adaptive advantage. [PDF]
Proc Natl Acad Sci U S A, 2023 RNA editing refers to the post-transcriptional modification of RNA sequences. Diverse eukaryotes are capable of mRNA editing, most commonly through enzymatic deamination of adenosine-to-inosine (A-to-I) (1–3).
Lewis ZA.
europepmc +2 more sources
A-to-I RNA editing promotes developmental stage–specific gene and lncRNA expression [PDF]
Genome Research, 2016 A-to-I RNA editing is a conserved widespread phenomenon in which adenosine (A) is converted to inosine (I) by adenosine deaminases (ADARs) in double-stranded RNA regions, mainly noncoding. Mutations in ADAR enzymes in Caenorhabditis elegans cause defects
Boaz Goldstein +5 more
openalex +2 more sources
The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers. [PDF]
Genomics Proteomics Bioinformatics, 2023 Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers.
Wu S, Fan Z, Kim P, Huang L, Zhou X.
europepmc +3 more sources
Illuminating spatial A-to-I RNA editing signatures within the Drosophila brain [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance A fundamental question in contemporary neuroscience is how the remarkable cellular diversity required for the intricate function of the nervous system is achieved.
Anne L. Sapiro +8 more
openalex +2 more sources
PLoS ONE, 2012 A-to-I RNA editing is a post-transcriptional modification of single nucleotides in RNA by adenosine deamination, which thereby diversifies the gene products encoded in the genome.
Hu Zhu +14 more
openalex +3 more sources